NIH-CSR <script type="text/javascript"> var wmNotice = "UNT Web Archive - External links, forms, and search boxes may not function within this collection. Url: http://cms.csr.nih.gov/PeerReviewMeetings/CSRIRGDescription/EMNRIRG/CADO.htm time: 15:09:17 Sep 20, 2008"; var wmHideNotice = "hide"; var contextRoot = "https://webarchive.library.unt.edu/eot2008/"; </script> <script type="text/javascript" src="https://webarchive.library.unt.edu/eot2008/js/disclaim.js"></script> <span id="Postingname3_PostingDisplayName">Cellular Aspects of Diabetes and Obesity Study Section [CADO]</span> (EMNRIRG)

[CADO Roster]

The Cellular Aspects of Diabetes and Obesity study section [CADO] includes all aspects of metabolic regulation related to type 1 and type 2 diabetes, including: islet biology; insulin secretion and action; insulin signal transduction pathways and their regulation; and obesity and adipocyte biology (including adipocyte differentiation and function).

Specific areas covered by CADO:

Insulin action on glucose transport and on cell differentiation, proliferation, growth, and survival
Differentiation, development, growth, and function of pancreatic islets; beta cell replacement; and stem cell biology
Biosynthesis, trafficking and secretion of insulin and other islet hormones and novel factors that coordinate central and peripheral communication of nutrient status
Mechanisms of regulation of insulin secretion by metabolites, ion fluxes, signal transduction, and autonomic and neuroendocrine pathways
Mechanisms of insulin signaling, and glucose transport
Downstream signaling pathways in insulin action, including the actions of scaffold proteins, phospholipids, kinases, and phosphatases
Differentiation and function of adipocytes, including: signal transduction mechanisms that control gene expression and cell function, as well as the structure and function of adipocyte-secreted biologically active molecules
Genetics of obesity and diabetes including analysis of the functional consequences of specific genetic alterations concerning obesity and/or diabetes

CADO has the following shared interests within the EMNR IRG:

With Molecular and Cellular Endocrinology [MCE]: Polypeptide hormone synthesis, secretion, and trafficking are areas of shared interest with MCE. In general, studies of hormone synthesis, secretion, trafficking, and signal transduction are referred to MCE. However, if the primary focus is islet or adipocyte hormone secretion, metabolic regulation, beta cell function, adipocyte differentiation, or cross-talk with insulin signaling, the application could be referred to CADO.
With Integrative and Clinical Endocrinology and Integrative Reproduction [ICER]: The study of Polycystic Ovarian Syndrome (PCOS) overlaps with ovarian dysfunction. When the application is focused on gonadal biology assignment could be to ICER. The application could be referred to CADO, IPOD or CIDO, when the focus is insulin action or insulin resistance in PCOS.
With Pregnancy and Neonatology [PN]: An application could be referred to PN if it focuses primarily on placental biology, pregnancy complications, or immediate fetal or maternal outcomes. If it focuses on insulin secretion or long-term diabetes outcomes, it could be referred to CADO, IPOD, or CIDO.
With Integrative Physiology of Obesity and Diabetes [IPOD]: Applications where the focus is on beta cell biology and/or physiology, insulin signaling and action, and adipocyte biology/physiology may be assigned to CADO. Applications focusing on general carbohydrate, lipid, and/or protein metabolism in the context of obesity and diabetes may be assigned to IPOD or CIDO.
With Clinical and Integrative Diabetes and Obesity [CIDO]: CADO and CIDO share conceptual and methodological interests. In general, applications that address more basic aspects of metabolic regulation (e.g., those using cell or tissue systems) may be referred to CADO; those using animal models may be referred to IPOD. Those focusing on human or animal models to validate hypotheses related directly to human pathophysiology may be referred to CIDO. Applications focusing on the actions of insulin and other hormones influencing energy homeostasis in the whole organism or integrating whole body insulin resistance and Polycystic Ovarian Syndrome (PCOS), especially in humans, may be referred to CIDO.
With Integrative Nutrition and Metabolic Processes [INMP]: Applications focusing on lipoproteins or lipid metabolism could be referred to INMP. Applications focusing on basic aspects of metabolic regulation related to obesity or diabetes could be referred to CADO or IPOD.

CADO has the following shared interests outside the EMNR IRG:

With the Genes, Genomes, and Genetics [GGG] IRG: Genetics of obesity and diabetes may be areas of shared interest with GGG. Models of the complex genetic questions and mapping in animals or humans could be referred to GGG. Analysis of the functional consequences of specific genetic alterations concerning obesity and/or diabetes could be referred to CADO or CIDO. Genomic approaches to the molecular physiology of obesity and/or diabetes should be assigned in a manner consistent with the main focus of the application. If genomic tools (e.g., DNA or protein microarrays, high throughput sequencing, SNP detection, bioinformatics) are used primarily to address questions regarding the physiology/pathogenesis of these states, the application could be referred to CADO, IPOD, or CIDO. If a major focus is development of genomic techniques/materials for the study of these phenotypes, the application could be referred to GGG.

With the Biology of Development and Aging [BDA] IRG: There may be shared interests in the area of aging research. Studies of metabolic regulation related to obesity and diabetes, regulation of nutrient flux and metabolism, and adipocyte biology could be referred to CADO, IPOD, or CIDO. BDA may review applications with a primary emphasis on aging issues (i.e., on the role of aging changes or co-morbidity-related factors affecting pathogenesis of diabetes and obesity in the elderly) when the study transcends a single organ system or discipline or when the focus is on strategies to alter the rate of aging through metabolic processes. BDA could also review applications that focus on the effects of diabetes and obesity on pathophysiologic processes in the elderly when the study transcends a single organ system or discipline.
With Bioengineering Sciences and Technologies [BST] IRG: Shared interest exists in the measurement of intracellular and physiological levels of glucose and other metabolites. Applications that propose the development of new sensor technology are appropriate for BST; studies that use the instrumentation to monitor metabolite levels are appropriate for CADO, IPOD, or CIDO.
With the Immunology [IMM] IRG: Applications on autoimmune aspects of Type 1 diabetes that focus primarily on immunity could be referred to IMM. When the experimental focus is the effects of autoimmunity on beta cell function assignment could be to CADO.
With the Oncological Sciences [ONC] IRG: Obesity or insulin resistance as a risk factor for cancer is an area of shared interest with ONC. If the primary focus is oncogenesis the application could be referred to ONC. If the focus is mechanisms related to metabolic fuel homeostasis, glucose homeostasis or insulin action on cell growth, it may be referred to CADO, IPOD, or CIDO. Applications that explore the relationship between insulin/IGF signaling and cancer of endocrine or neuroendocrine tissues could be referred to CADO.
With the Cardiovascular Sciences [CVS] IRG: In general, applications focusing on the biology or pathogenesis of obesity or diabetes could be referred to CADO, IPOD or CIDO. Studies relating to cardiovascular metabolism or blood flow as a chronic adaptation to obesity or diabetes leading to cardiac hypertrophy and heart failure, or the effects of insulin on the cardiovascular system could be assigned to CVS. Applications dealing with the role of lipids in inflammation of the vascular system, particularly in atherosclerosis, could be assigned to CVS.
With the Digestive Sciences [DIG] IRG: 1) Studies of GI hormones may be an area of shared interest with DIG. Applications that focus on gut-mediated effects on feeding, satiety, energy-expenditure and islet hormone secretion could be referred to CADO or CIDO. When the primary focus is on hormones of the gastrointestinal tract and peptides and neurotransmitters of the brain-gut axis, applications could be assigned to DIG. (2) There is also shared interest in the area of cholesterol metabolism and complications of diabetes. Applications dealing primarily with lipid metabolism in the liver as it relates to Non-Alcoholic Fatty Liver Disease (NAFLD) could be assigned to DIG, while applications focusing on lipoproteins, lipid metabolism and diabetic complications could be assigned to CADO, IPOD, or CIDO.
With the Renal and Urological Sciences [RUS] IRG: Studies of renal complications of diabetes may be referred to RUS; studies that focus on diabetes may be referred to CADO, IPOD or CIDO.
With Surgical Sciences, Biomedical Imaging and Bioengineering: Applications focused on islet physiology may be referred to CADO. Applications focused on improving islet transplantation outcomes may be referred to SBIB.
With the Molecular, Cellular, and Developmental Neuroscience [MDCN] IRG: Cellular and molecular studies that focus on diabetic neuropathy may be referred to MDCN; studies that focus on diabetes may be referred to CADO, IPOD or CIDO.
With the Integrative, Functional, and Cognitive Neuroscience [IFCN] IRG: Applications involving the central nervous system with a focus on metabolic homeostasis or causes of obesity are areas of shared interest with IFCN and could be referred to CADO, IPOD or CIDO when end points relate primarily to cellular or systemic metabolic phenotypes or energy balance; and to IFCN when the focus is on the neural basis of ingestive behaviors or satiety.
With the Brain Disorders and Clinical Neuroscience [BDCN] IRG: Physiological or clinical studies of diabetic neuropathy may be referred to BDCN; studies that focus on diabetes may be referred to CADO, IPOD or CIDO.