[SBIR/STTR Rosters]
The topics covered in ETTN (13): Molecular and Cellular Neuroscience Small Business SEP include those areas on the molecular and cellular level. In general, the projects involve development of devices, reagents, and software to probe channels, signal transduction, and the transducers themselves. Studies may involve basic biological processes that underlie or may be altered by disease processes. Examples of devices might include development of imaging and recording techniques; analytical and system controlling software; monitoring and assay platforms; neuroprosthetic devices; biosensors; and stem cells and cell culture systems. Projects might also focus on neurodrug discovery and development; molecular manipulation and engineering; development of specific research reagents and assays; therapeutics; and proteins that interact with and modulate neuroreceptors, transporters and transducers.
WITHIN IRG OVERLAP STATEMENTS
The ETTN 10, 11 and 12 Small Business SEPs share some interests with the ETTN 13 SEP. If the focus is on more molecular aspects, non-vertebrate models, and less immediate clinical applications then the application may be reviewed within ETTN 13. However, if the clinical implications are more immediate then they may be reviewed within ETTN 10, 11, or 12.
The ETTN 10, 11 and 12 and ETTN (13) share interests in neuropathology. ETTN 10-12 may review small business applications focused on a neural disease or disease process. ETTN (13) may review small business applications focused on a basic neural cellular or molecular mechanisms.
SHARED INTEREST STATEMENTS
ETTN Small Business Activities have the following shared interests outside the IRG:
With the Genes, Genomes and Genetics [GGG] IRG: Assignment of a molecular genetics/genomics/genetics application to ETTN should be based on the nature of scientific question(s) being addressed. Studies that are directed at a neural system disease could be assigned to the ETTN IRG, even when genetics, genomic or molecular technologies are being developed. Assignment could be to GGG if the focus of applications is on emerging genetic or genomic technologies(s) or if multiple diseases or organ systems are being targeted with genetic, genomic or molecular genetic technologies.
With the Risk, Prevention and Health Behavior [RPHB] IRG: While ETTN reviews small business applications on the neuroscience of sensory systems other than vision, as well as tools for use in basic neuroscience research, applications dealing with quality of life issues due to sensory impairment would be reviewed by RPHB.
With the Biobehavioral and Behavioral Processes [BBBP] IRG: Devices or procedures for studying animal behavior could be assigned to the BBBP IRG. Devices or procedures for use in integrative neuroscience could be assigned to the ETTN IRG.
With the Musculoskeletal, Oral, and Skin Sciences [MOSS] IRG: There is shared interest with the ETTN IRG with respect to motor systems and sensorimotor integration. If the application addresses neural control of normal biological motor function then the ETTN IRG may be appropriate. If the application addresses rehabilitation, electromyography, neural prostheses or restoration of body movement, then the MOSS IRG may be appropriate.
With the Surgical Sciences, Biomedical Imaging, and Bioengineering [SBIB] IRG: Development of imaging techniques and imaging systems, implants and prosthetic devices are shared interests. If the focus is the development of technologies assignment could be to SBIB. If the focus is application of technologies for use in a neuroscience related context the assignment could be to ETTN.
With the Biology of Development and Aging [BDA] IRG: Areas of shared interest include basic or applied research on the development of devices (for diagnosis, monitoring symptoms, developing treatments) and models of neurological disorders of aging (i.e. Alzheimer’s, Parkinson’s, Multiple Sclerosis, and stroke). If the focus is on novel devices and monitoring systems for geriatric patients with age-related conditions involving multiple systems and/or multifactorial mechanisms, interventions for age-dependent cognitive and physiological deficits in humans (such as menopause, frailty, and infections) or studies of geriatric morbidities that transcend single organ systems or disciplines, then assignment could be to the BDA IRG. Development of technologies for use in a general neuroscience-related context could be assigned to the ETTN IRG.