[CSRS Roster]
The Cellular Signaling and Dynamics (CSD) study section will be restructured and renamed the Cellular Signaling and Regulatory Systems (CSRS) study section and will review applications that focus on the initiation and execution of programs that control cellular homeostasis and physiology. A distinguishing characteristic of these applications is an emphasis on signaling networks and the coordination of processes related to cell proliferation, survival, and growth.
Specific areas include:
- Integrative cell physiology, e.g., stress, clocks, cellular modeling
- Mitosis and meiosis as related to cell cycle regulation
- Cell differentiation and transformation
- Cell size and mass, asymmetry and polarity
- Molecular control of proliferation and senescence
- Programmed cell death and apoptosis particularly in the context of stress, growth, and transformation
- Proteolytic mechanisms associated with cell cycle, senescence, and death
- Application of state-of-the-art technologies such as imaging and computational modeling of cellular signaling networks
The CSRS Study Section has the following shared interests within the CB IRG:
With the ICI Study Section: Cell differentiation, transformation and polarity are shared areas of interest. Applications focused on regulation of these processes by the extracellular matrix or cell-cell signaling or those related to morphogenesis could be reviewed by ICI. Those focused on intracellular signaling networks and pathways related to these processes could be reviewed by CSRS.
With the MBPP Study Section: Post-translational modifications such as ubiquitin/proteasome, sumolation, etc. are areas of shared interest. Applications related to trafficking of modified proteins and modifying enzymes and proteasomal proteolysis could be reviewed by MBPP. Those focused on to the signaling networks regulating these mechanisms in the context of the cell cycle or cell senescence could be reviewed by CSRS.
With the CSF Study Section: Cell signaling is an area of shared interest. Applications focused on the translocation or recycling of signaling receptors and molecules could be reviewed in CSF. Those focused on signaling networks and cascades could be reviewed in CSRS.
With the MIST Study Section: Cell signaling is an area of shared interest. Applications focused on biochemical and molecular mechanisms of G-protein and 7TM receptors could be reviewed by MIST. Those with an emphasis on signaling networks and the coordination of processes related to the cell cycle, proliferation, survival and growth could be reviewed by CSRS.
The CSRS study sections have the following shared interests outside the IRG:
With the Bioengineering Sciences and Technologies [BST] IRG: Shared areas of interest are computational biology and cell imaging. If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to cellular signaling pathways or networks, assignment could be to CSRS. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.
With the Biology of Development and Aging [BDA] IRG: Shared areas of interest are intracellular signaling. If the emphasis is specifically on a developmental or aging question, assignment could be to BDA. If the focus is on the fundamental study of cellular signaling processes, assignment to could be to CSRS.
With the Genes, Genomes and Genetics IRG (GGG): Shared interests include signal transduction pathways, cell cycle control and regulation. If the focus is on molecular genetic mechanisms or regulation of DNA metabolism or gene expression, assignment could be to GGG. If the focus is on the elucidation of signaling pathways and networks that regulate cell cycle control and apoptosis, assignment could be to CSRS.
With the Organ-system/Disease IRGs - Hematology [HEME]; Cardiovascular Sciences [CVS]; Endocrinology, Metabolism, Nutrition, & Reproductive Sciences [EMNR]; Musculoskeletal, Oral, & Skin Sciences [MOSS]; Digestive Sciences [DIG]; Respiratory Sciences [RES]; Oncological Sciences [ONC]; and Renal & Urological Sciences [RUS]: Shared areas of interest are cellular signaling processes in the context of a specific organ or disease. If the focus is physiological, i.e., the scientific question relates to a specific organ system or disease, assignment could be to the appropriate IRG. If the main focus is basic, i.e., the scientific question is focused on fundamental cellular signaling processes which may be applicable to multiple diseases or organ systems, or where a particular cell or tissue type is chosen only as a model system, assignment could be to CSRS.
With the Neuroscience IRGs - Molecular, Cellular & Developmental Neuroscience [MDCN]; Integrative, Functional, & Cognitive Neuroscience [IFCN]; and Brain Disorders & Clinical Neuroscience [BDCN]: Shared areas of interest are cellular signaling processes in neuronal systems. If the focus is on processes specific to the nervous system or on a physiological or clinical problem, assignment could be to the appropriate neuroscience IRG. If the primary focus is on the fundamental study of cellular signaling processes and the nervous system is used as a convenient model, assignment could be to CSRS.
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