NIH-CSR <script type="text/javascript"> var wmNotice = "UNT Web Archive - External links, forms, and search boxes may not function within this collection. Url: http://cms.csr.nih.gov/PeerReviewMeetings/CSRIRGDescription/MDCNIRG/NTRC.htm time: 14:48:17 Sep 20, 2008"; var wmHideNotice = "hide"; var contextRoot = "https://webarchive.library.unt.edu/eot2008/"; </script> <script type="text/javascript" src="https://webarchive.library.unt.edu/eot2008/js/disclaim.js"></script> <span id="Postingname3_PostingDisplayName">Neurotransporters, Receptors, Channels and Calcium Signaling Study Section [NTRC]</span> (MDCNIRG)

Formerly MDCN-4

[NTRC Roster]

The Neurotransporters, Receptors, Channels and Calcium Signaling [NTRC] Study Section reviews studies of signal transduction pathways in neurons, muscles, and other excitable cells with particular emphasis on cellular regulation and physiology. This includes studies of calcium physiology, regulation of ionic gradients, ion pumps and molecular transporters, ion channels, and synthesis and regulation of transduction molecules. Studies may integrate molecular, cellular, electrophysiological, and imaging approaches to examine molecular regulation, transduction, biochemical changes, cellular physiology, and functional consequences. Emphasis is on fundamental cellular mechanisms, including those relevant to disease processes.

Specific areas covered by NTRC:

Intracellular regulation of calcium; calcium channels, calcium storage, homeostasis, and buffering; calcium as a second messenger; electrophysiology; calcium imaging
Ion pumps and molecular transporters; electrochemical coupling; maintenance of ionic gradients; membrane properties and electrodynamics; imaging studies
Ion channels and neurotransmitter receptors; electrophysiological studies within the context of cellular physiology; interactions with second messenger systems; regulation and modulation of ion channels and receptors; ionotropic and metabotropic receptors
Synthesis, insertion and regulation of transduction molecules; genetic regulation, transcription/translation, protein modification, localization, assembly, turnover, and degradation; local regulation of synaptic structure and function [i.e., insertion, accumulation, localization]
Muscle cell electrophysiology and propagation of electrical signals

NTRC has the following shared interests within the MDCN IRG:

With Synapses, Cytoskeleton and Trafficking [SYN]: SYN and NTRC share interests in the area of synaptic function and the cellular regulation of signal transducer molecules. If the focus is on fundamental cellular, biochemical and molecular mechanisms of neuronal cell function, the application may be appropriate for SYN. NTRC may be appropriate for studies focusing on electrophysiology and signal transduction pathways.
With Biophysics of Neural Systems [BPNS]: BPNS and NTRC share interests in the area of signal transduction. NTRC may be appropriate for studies of cellular electrophysiology and the synthesis and regulation of the transduction molecules, and most studies involving calcium pathways, while BPNS may be appropriate for molecular, structural, and biophysical studies.
With Molecular Neuropharmacology and Signaling [MNPS]: MNPS and NTRC have significant shared interests in the area of signal transduction, especially with respect to second-messenger pathways. NTRC may be appropriate for studies of cellular electrophysiology [especially involving calcium], while MNPS may be appropriate for neurochemical and pharmacological studies.
With Neurodifferentiation, Plasticity, and Regeneration [NDPR]: NDPR and NTRC share an interest in the plasticity of synaptic connections. NDPR may be appropriate when the emphasis is predominantly on the cellular, biochemical and molecular aspects of synaptic plasticity, while NTRC may be appropriate when the emphasis is more on cellular electrophysiology [especially involving calcium].

NTRC has the following shared interests outside the MDCN IRG:

With the Cell Biology [CB] IRG: 1) The CB IRG and NTRC share interests in contractile proteins and muscle research. The CB IRG may be appropriate for general cellular studies of muscle structure and contractile proteins; NTRC may be appropriate for electrophysiological studies of signal transduction. (2) The CB IRG also shares interests with NTRC in the area of vision research. Applications that require specialized knowledge or appreciation of the retina or the posterior portion of the eye may be appropriate for the CB IRG; applications that focus on fundamental aspects of molecular transporters, ion pumps, and cellular electrophysiology, particularly if they involve calcium, may be appropriate for NTRC.
With the Cardiovascular Sciences [CVS] IRG: The CVS IRG and NTRC share interests in cardiac muscle. CVS may be appropriate for clinical aspects of cardiac muscle, especially in the context of heart disease, but NTRC may be appropriate for basic electrophysiological studies. CVS may also be appropriate for review of skeletal muscle excitation-coupling [E-C coupling].
With the Musculoskeletal, Oral and Skin Sciences [MOSS] IRG: The MOSS IRG and NTRC share an interest in skeletal muscle. MOSS may be appropriate for studies of clinical aspects of skeletal muscle and/or skeletal muscle force production, but NTRC may be appropriate when the primary focus in on neural structure and function and/or neuronal control of muscle force production.
With the Digestive Sciences [DIG] IRG: The DIG IRG and NTRC share an interest in gastro-intestinal signal transduction. Studies focusing on signal transduction and neuroendocrine peptides may be appropriate for DIG; however, studies focusing on neuroendocrine peptides or general neuronal signal transduction may be appropriate for NTRC.
With the Integrative, Functional and Cognitive Neuroscience [IFCN] IRG: (1) The IFCN IRG and NTRC share interests in signal transduction and transport in the areas of the neuronal basis of behavior; neuroendocrine and neuroimmune function; rhythms and oscillatory behavior; sensory function; and motor function. The IFCN IRG may be appropriate for such signal transduction and transport studies when the context is on integrated circuits, systems, and behavior. However, NTRC may be appropriate for studies of transport or transduction molecules at the cellular electrophysiological level. (2) The IFCN IRG and NTRC also share interests in long-term potentiation [LTP] and long-term depression [LTD]. Applications involving LTP and LTD in learning may be assigned to the IFCN IRG, but applications involving the cellular and molecular basis of LTP/LTD may be assigned to NTRC, especially if they involve intracellular calcium signaling or physiology.
With the Brain Disorders and Clinical Neuroscience [BDCN] IRG: (1) The BDCN IRG shares interests with NTRC in neurological disorders. If a study involves research in neural disorders and injury, BDCN may be appropriate; however, if the study involves fundamental cellular mechanisms in signal transduction, NTRC may be appropriate. (2) BDCN also shares interests with NTRC in the area of vision research. Applications that require specialized knowledge or appreciation of the anterior portion of the eye may be appropriate for the BDCN IRG; while applications that focus on fundamental aspects of molecular transporters, ion pumps, and cellular electrophysiology, particularly if they involve calcium, may be appropriate for NTRC.