[CMBG Roster]
The CMBG Study Section reviews applications on glial-neuronal, glial-glial, and related interactions [Schwann cells, oligodendrocytes, astrocytes, and microglia]; mechanisms of glial differentiation, metabolism, and myelination; neuroinflammation and neuroimmune function across the life span. Also considered are the roles of genetic factors, trophic molecules and extrinsic influences in these processes.
Specific areas covered by CMBG:
- Basic biology of glial cells (oligodendrocytes, astrocytes, Schwann Cells, microglia), growth and differentiation of glial cells; inductive signals for the initiation, synthesis, regulation, maintenance, and degradation of myelin; remyelination processes; mechanisms involved in demyelinating and dysmyelinating diseases.
- Neuroglial interactions; growth factors and receptors involved in neuroglial function; role of glia in synaptic transmission; role of glia in the homeostasis of the neural environment.
- Glial response to injury or infection; the innate immune function of glial cells; inductive signals, phagocytosis [microglia], role of neuroimmune molecules and the immune response in the nervous system; neuroinflammation in injury, repair processes, and/or neurodegenerative disease; secondary inflammation.
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Neuroimmune functions (and dysfunctions) across the life span; neuroimmune molecules [e.g., cytokines, chemokines, proteases] and their interactions with the nervous system.
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Primary diseases of glial cells, role of glia in disorders affecting the nervous system such as the lysosomal storage diseases.
CMBG has the following shared interests within the MDCN IRG
- With Neurotransporters, Receptors, Channels and Calcium Signaling [NTRC]: NTRC and CMBG have shared interests in the area of glial electrophysiology. CMBG may be appropriate for studies focused on electrophysiological properties related to basic glial biology, while NTRC may be appropriate for studies focused on general electrophysiology.
- With Neurodifferentiation, Plasticity, and Regeneration [NDPR]: NDPR and CMBG share review responsibilities regarding glial cell biology. Studies that focus on the role of glia in axon outgrowth, synapse formation, and morphological development of neurons may be appropriate for NDPR. Studies that focus on glial cell biology, myelination, and response to injury may be appropriate for CMBG.
- With Cellular and Molecular Biology of Neurodegeneration [CMND]: CMBG and CMND have shared interests in the area of neuroglial interactions and glial mediated inflammation. If the study is focused on the role of glia within the context of a specific neurodegenerative disorder, the application may be reviewed in CMND. If the application is focused on neuroglial interactions in general or on the role of inflammation in diseases of glia, the application may be reviewed in CMBG.
CMBG has the following shared interests outside the MDCN IRG:
- With the Immunology IRG [IMM]: CMBG has shared interests with the IMM IRG in the area of immune function. The IMM IRG may be appropriate when the emphasis is on immune function in a broad context or when emerging immunologic techniques are involved. CMBG may be appropriate when the emphasis is on neuroimmune function.
- With the Brain Disorders and Clinical Neuroscience IRG [BDCN]: CMBG and the BDCN IRG share interest in neuroimmune functions. BDCN may be appropriate for studies focused on whole organ, pathogenesis, or injury. CMBG may be appropriate for studies focused on cellular and molecular mechanisms.
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