Definition of aberrant crypt foci - NCI Dictionary of Cancer Terms

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aberrant crypt foci (uh-BAYR-unt KRIPT FOH-sy)

ACF. Clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci form before colorectal polyps and are one of the earliest changes that can be seen in the colon that may lead to cancer. Also called ACF.

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