[SAT Roster]

The Surgery, Anesthesiology, and Trauma Scientific Review Group reviews grant applications in the complementary disciplines of surgery and anesthesiology, as well as in surgical critical care.  Sepsis studies that are reviewed by SAT are in general limited to multi-organ or systemic host injury responses to complex insults such as trauma, disseminated infection, or surgical stress; many such responses occur as postoperative complications.   Anesthesiology and surgical critical care are more comprehensively reviewed.  

Specific areas covered by SAT:

• Metabolic, hormonal, or inflammatory/immune injury responses to trauma, burn, sepsis, hemorrhage, ischemia-reperfusion, cardiopulmonary resuscitation, or surgical stress.
  
  
• Genetic determinants of response to injury, and genetic or pharmacologic approaches to promote modulation of injury.
  
  
• Pathogenesis and amelioration of shock and multiple organ dysfunction/failure.
  
  
• Pathogenesis/amelioration of hypoxic or oxidative cell/ tissue insults.
  
  
• Multi-modal treatment of critical injury, including nutritional support.
  
  
• Wound healing, including tissue repair/regeneration.
  
  
• Pharmacology of general and local anesthetics,
  including mechanisms of general and local anesthesia and of anesthetic side effects.
  
  
• Pain mechanisms and pain management in surgery and anesthesiology.
  
  
• Surgical aspects of organ, tissue, and cellular transplantation.
  
  
• Surgical aspects of organ preservation.
  
  
• Surgical approaches to organ/tissue-specific disease, injury, or repair.

SAT has the following shared interest within the SBIB IRG:

• With Bioengineering, Technology, and Surgical Sciences [BTSS]: Applications dealing with anesthesiology, surgical critical care or multi-organ or systemic injury responses to complex insults in the perioperative setting would in general be referred to SAT; those in which the emphasis is on integrating physical, chemical, mathematical or engineering principles with the above areas would be referred to BTSS.

SAT has the following shared interest outside the SBIB IRG:

• With the Genes, Genomes, and Genetics [GGG] IRG:  In general, applications that focus on genetics would be referred to GGG; applications that focus on injury or the treatment of injury, including those with a genetic component, would be referred to SAT.
  
  
• With the Immunology [IMM] IRG:  In general, applications dealing with inflammatory injury responses mediated by immune activation in trauma, burn, wound, hemorrhage, ischemia-reperfusion, or post-operative sepsis would be referred to SAT; those dealing with response to inflammatory injury in a non-surgical context would be referred to IMM.  In general, organ/tissue/cellular transplantation applications that are immunology focused (e.g., that deal with recipient rejection of, or tolerance to, donor xeno- or allografts) would be referred to IMM; transplantation applications that focus on surgery, for example, studies of organ/ tissue/ cell injury responses to hypo- or normo-thermic ischemia-reperfusion insult would be referred to SAT.
  
  
• With the Infectious Diseases and Microbiology [IDM] IRG: In general, applications focusing on immune responses to local and/or disseminated infection (i.e., post operative wound infection, abscess or sepsis) would be referred to SAT; applications focusing on immune response to infection in a non-surgical context, or which focus on the infectious agent, would be referred to IDM.
  
  
• With the Hematology [HEME] IRG: In general, applications dealing with hypo- or hyper-coagulability or complement activation in the context of surgery (trauma, hemorrhage, post-operative sepsis) would be referred to SAT; those dealing with coagulability or complement activation in non-surgical contexts would be referred to HEME.
  
  
• With the Cardiovascular Sciences [CVS] IRG:  In general, studies of cardiovascular problems, including studies of cardiac function in response to myocardial ischemia/reperfusion injury associated with cardiac surgery or cardiopulmonary bypass would be referred to CVS. Those dealing with ischemia-reperfusion injury to organs/ tissues in a surgical context would be referred to SAT.
  
  
• With the Endocrinology, Metabolism, Nutrition, and Reproductive Sciences [EMNR] IRG: In general, studies of metabolic or hormonal responses to hypoxic, oxidative, or surgical insults, nutritional support in the context of surgical care (including the treatment of burns, trauma and sepsis) would be referred to SAT.  Studies of nutritional support in the treatment of metabolic (excluding those of the digestive system) or hormonal disorders and diseases would normally be referred to EMNR.
  
  
• With the Digestive Sciences [DIG] IRG: In general, applications dealing with gastrointestinal aspects of trauma, burns, and surgical critical care would be referred to SAT; applications focused on ischemia would be referred to DIG or SAT depending on the focus of the study.  Applications focused on nutritional support in the treatment of digestive diseases would be referred to DIG; studies of nutritional support in the context of surgical care (including the treatment of burns, trauma and sepsis) would be referred to SAT.  Applications focused on other aspects of the gastrointestinal system would be referred to DIG.
  
  
• With the Respiratory Sciences [RES] IRG:  In general, applications dealing with pulmonary aspects of trauma, burns, ischemia, and surgical critical care would be referred to SAT; applications dealing with other aspects of the lung, including responses of the pulmonary system to surgical procedures, would be referred to RES.
  
  
• With the Integrative, Functional, and Cognitive Neuroscience [IFCN] IRG: In general, studies of neural mechanisms and perception of pain would be referred to IFCN; studies of pain the context of surgery or anesthesia would be referred to SAT.
  
  
• With organ-specific IRGs:  In general, studies of organ-specific disorders treated surgically would be referred to the appropriate organ-specific IRG; sdealing with multi-organ or systemic injury responses to organtudies (1) -specific disorders (e.g., hemorrhagic shock from a ruptured aortic aneurysm or sepsis developing from a liver abscess) or (2) focused on the design, development, or validation of novel surgical procedures would be referred to SAT.