NIH-CSR <script type="text/javascript"> var wmNotice = "UNT Web Archive - External links, forms, and search boxes may not function within this collection. Url: http://cms.csr.nih.gov/PeerReviewMeetings/CSRIRGDescription/IDMIRG/PCMB.htm time: 14:19:45 Sep 20, 2008"; var wmHideNotice = "hide"; var contextRoot = "https://webarchive.library.unt.edu/eot2008/"; </script> <script type="text/javascript" src="https://webarchive.library.unt.edu/eot2008/js/disclaim.js"></script> <span id="Postingname3_PostingDisplayName">Prokaryotic Cell and Molecular Biology Study Section [PCMB]</span> (IDMIRG)

[PCMB Roster]

The Prokaryotic Cell and Molecular Biology Study Section reviews applications addressing the genetics, biochemistry, structure, physiology and behavior of bacteria, archaea, and their phages. The focus of the study section is on research whose results will be applicable principally to microbial organisms. Studies may use pathogenic or nonpathogenic organisms and be at the genetic, molecular, biochemical, cellular, or community level.

Specific areas covered by PCMB:

Genome organization and dynamics
Mobile genetic elements and gene transfer
Replication, recombination, mutation, and repair
Transcription and RNA processing
Gene expression and regulation
Protein synthesis and modification
Export, secretion, and localization
Assembly of supramolecular structures
Morphogenesis and cell division
Regulatory networks and dynamics
Modeling of microbial cell processes
Intercellular signaling and other cell-cell interactions
Environmental interactions and symbiosis
Intermediary metabolism and energetics
Development and differentiation
Stress responses, survival, and death
Chemotaxis and motility
Functional genomics and proteomics

PCMB has the following shared interests within the IDM IRG:

With Bacterial Pathogenesis [BACP]: Proposals that focus on basic cellular mechanisms in bacteria, rather than directly on the mechanism of pathogenesis, could be assigned to PCMB even if the results have potential implications for pathogenic mechanisms. If the focus is on the examination of these basic cellular mechanisms in the context of a bacterial infection, assignment could be to BACP.
With Drug Discovery and Mechanisms of Antimicrobial Resistance [DDR]: Applications focused on particular microbial molecular targets for the purpose of discovering new antibiotics or microbicides, or to understand resistance mechanisms could be assigned to DDR; applications that involve potential antimicrobial targets, but do not focus on identification of novel compounds, could be assigned to PCMB.
With Vector Biology [VB]: If the emphasis is on the vector, the proposal could be assigned to VB. If the emphasis is on the microbe, the proposal could be assigned to PCMB or another appropriate IDM study section.

PCMB has the following shared interests outside the IDM IRG:

With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG: If the emphasis is on understanding a molecule (e.g., an enzyme) to study itsgeneralmode of action, assignment could be to BCMB. If the emphasis is on understanding the action of a molecule in the context of a process unique to a microbial cell, the proposal could be assigned to PCMB.
With the Cell Biology [CB] IRG: Cell biology studies of microbes (including those on model systems) where the results will principally apply to microbes (including pathogens) could be assigned to PCMB. Studies whose results will be broadly applicable across kingdoms (i.e., crosscutting studies) could be assigned to CB.
With the Genes, Genomes, and Genetics [GGG] IRG: Genetic studies of microbes (including those on model systems) where the results will principally apply to microbes (including pathogens) could be assigned to PCMB. Studies whose results will be broadly applicable across kingdoms (i.e., crosscutting studies) could be assigned to GGG. Proposals on evolution, ecology, or population biology of microbes (including bacteria and archaebacteria and their phages) could be assigned to GGG.
With the Bioengineering Sciences and Technologies [BST] IRG: Studies that employ computational modeling and simulation to understand complex processes, such as metabolism and gene circuitry in bacteria and archaea, could be assigned to PCMB. Studies targeted at the development of models and simulations for process design could be assigned to BST. Proposals that focus on the development of methods for functional genomics or proteomics of bacteria could be assigned to BST or GGG. Proposals that use functional genomics or proteomics to study bacterial processes could be assigned to PCMB.