NIH-CSR <script type="text/javascript"> var wmNotice = "UNT Web Archive - External links, forms, and search boxes may not function within this collection. Url: http://cms.csr.nih.gov/PeerReviewMeetings/CSRIRGDescription/EMNRIRG/PN.htm time: 14:16:43 Sep 20, 2008"; var wmHideNotice = "hide"; var contextRoot = "https://webarchive.library.unt.edu/eot2008/"; </script> <script type="text/javascript" src="https://webarchive.library.unt.edu/eot2008/js/disclaim.js"></script> <span id="Postingname3_PostingDisplayName">Pregnancy and Neonatology Study Section [PN]</span> (EMNRIRG)

[PN Roster]

The Pregnancy and Neonatology study section [PN] covers all aspects of intrauterine mammalian development from implantation through pregnancy, parturition and the neonatal period. Areas include the normal physiology of pregnancy, parturition and the postpartum period as well as clinical obstetrics, disorders of pregnancy, neonatal development and diseases of the newborn. In addition, research related to the immunology of pregnancy; maternal nutrition; the effects of pharmaceuticals, xenobiotic agents, and environmental toxicants on pregnancy; and placental endocrinology and function can be reviewed in PN. Techniques and/or research models utilized include: clinical and basic genetics, molecular biology, cellular and organ physiology, and integrative biology.

Specific areas covered by PN:

Trophoblast invasion, maternal-fetal interactions, and diagnosis and treatment of ectopic pregnancy
Placental development, trophoblast differentiation, placental endocrinology, transport functions and utero-placental blood flow
Pregnancy and mechanisms leading to parturition (including: endocrine, immunologic, infectious, and coagulation factors)
Disorders of pregnancy (preeclampsia, gestational diabetes, and other diseases affecting pregnancy)
Fetal and neonatal biology, including: fetal growth and development, fetal physiology, fetal diseases, in-utero infection, transition to extra-uterine life, and neonatal physiology and pathophysiology
Immunologic issues of pregnancy, including: immuno-tolerance mechanisms, immunologic basis of complications of pregnancy and loss of the fetus, and autoimmune diseases
Endocrinologic aspects of pregnancy as they relate to placental hormone production, endocrine disorders during pregnancy, and fetal endocrinology
Conditions leading to recurrent pregnancy loss, including factors related to: immunology, infection, and genetic or structural abnormalities of the reproductive system
Pregnancy-related studies of pharmacology and toxicology, including: placental transport mechanisms, pharmacokinetics of drugs during pregnancy, and the effects of metabolic products of pharmaceuticals and xenobiotics
Nutrition during pregnancy as it relates to: maternal physiology, placental function, fetal growth and development, and neonatal health
Pregnancy-related and neonatal aspects of sudden infant death syndrome (SIDS)

PN has the following shared interests within the EMNR IRG:

With Molecular and Cellular Endocrinology [MCE]: There is shared interest with aspects of endocrinology, including: steroidogenesis and hormone synthesis, secretion, and action. Applications dealing with placental function, the production and action of trophoblast hormones as well as actions of hormone on the placenta and fetal tissue may be directed to PN.
With Integrative and Clinical Endocrinology and Reproduction [ICER]: There may be shared interest with respect to endocrine changes in pregnancy. Applications dealing with endocrine functions that directly affect pregnancy outcome or placental and fetal function could be referred to PN.
With Cellular, Molecular, and Integrative Reproduction [CMIR]: There is shared interest with respect to uterine biology during the pre-implantation period. Applications focused on uterine function or biology could be referred to PN, while applications dealing with embryonic development in the pre-implantation period could be referred to CMIR.
With Cellular Aspects of Diabetes and Obesity [CADO]: There is shared interest in the area of diabetes during pregnancy (including insulin-dependent diabetes, non-insulin-dependent diabetes, and gestational diabetes). Studies that address fundamental aspects of glucose metabolism, glucose homeostasis, and glucose utilization could be reviewed in CADO. Proposals related to the pathophysiology, diagnosis, management, treatment and outcomes of diabetes during pregnancy could be reviewed in PN.
With Integrative Physiology of Obesity and Diabetes [IPOD]: There is shared interest in diabetes during pregnancy. Applications focused on carbohydrate metabolism, insulin secretion, pre- and post-natal diabetes and long-term diabetic outcomes may be referred to IPOD. Applications related to the pathophysiology of diabetes during pregnancy, maternal and fetal outcomes, and the diagnosis and clinical management of diabetes during pregnancy could be referred to PN.
With Integrative Nutrition and Metabolic Processes [INMP]: There is shared interest with applications that address nutrient metabolism during pregnancy. PN may be assigned studies on the impact of diet on pregnancy, pregnancy outcomes, fetal development and growth; whereas, INMP could be assigned studies involving abnormalities of fuel metabolism or fundamental nutrient biology during pregnancy.

PN has the following shared interests outside the EMNR IRG:

With the Cell Biology [CB] IRG: Studies of implantation relating to pregnancy could be referred to PN, however, if implantation is being used as a model system to address cell biology questions that can be generalized, CB may be more appropriate. Studies of fetal membranes could be referred to PN or to CB depending on whether the utility of the study's outcome is uniquely related to endocrinological issues.
With the Biology of Development and Aging [BDA] IRG : There is shared interest in the area of embryonic/fetal development. In general, applications focused on pregnancy and reproductive systems may be referred to PN. The application could be referred to BDA, if the focus is mechanism of development, it addresses the "primordial organ", or has implications that transcend a single organ system or discipline.
With the Health of the Population [HOP] IRG: Shared interest exists regarding maternal nutrition and pregnancy outcomes, specifically with regard to disorders of pregnancy. Studies that focus on genetics, molecular biology, cellular or organ physiology and integrative biology could be referred to PN. Studies that focus on the relationship between pregnancy outcomes and their relationship with socio-demographic factors, including population studies related to epidemiology or large-scale interventions, could be referred to HOP. Applications that focus on human behavioral aspects of maternal nutrition (eating patterns, compliance with nutritional, behavioral, or psychosocial interventions or interpersonal support) as a risk factor or intervention for pregnancy outcomes could be referred to HOP or RPHB.
With the Risk, Prevention and Health Behavior [RPHB] IRG: Shared interest exists regarding maternal nutrition and pregnancy outcomes, specifically with regard to disorders of pregnancy. Studies that focus on genetics, molecular biology, cellular and organ physiology and integrative biology could be referred to PN. Applications that focus on human behavioral aspects of maternal nutrition (eating patterns, compliance with nutritional, behavioral, or psychosocial interventions or interpersonal support) as a risk factor or intervention for pregnancy outcomes could be referred to HOP or RPHB.
With the Biobehavioral and Behavioral Processes [BBBP] IRG: There is shared interest in the area of the endocrinology of pregnancy as it relates to placental hormone production, maternal physiology, placental function, fetal growth and development and neonatal health, and mechanisms leading to parturition. Applications focused on basic aspects of these physiological process may be assigned to PN, whereas applications focused on the effects of behavioral factors on pregnancy, parturition and lactation or of the effects of these processes on feeding, cognition, regulation of emotions, psychopathology, behavioral development, parental and affiliative behavior, and other social processes could be assigned to BBBP.
With the Immunology [IMM] IRG: There is shared interest in the area of reproductive immunology, including immuno-deficiency states in pregnancy and immuno-tolerance of pregnancy. Applications that focus on immune phenomena as they relate to pregnancy and pregnancy outcomes may be referred to PN. Applications that focus on immune mechanisms or processes may be referred to IMM.
With the Infectious Diseases and Microbiology [IDM] IRG: There is shared interest in genital tract infections in pregnancy, infection related pre-term labor, postpartum infections, and neonatal sepsis. Proposals that directly relate to pregnancy or reproduction could be referred to PN. Applications that focus on the infectious agent, mechanism of infection or treatment could be referred to IDM.
With the AIDS and Related Research [AARR] IRG: There is shared interest in the area of vertical transmission of HIV and its therapy during pregnancy. However, because of the accelerated review of AIDS grant applications, these proposals generally will be referred to AARR.
With the Oncological Sciences [ONC] IRG: There is shared interest with areas of gestational trophoblast neoplasias. Studies related to placental biology and function, could be assigned to PN. In contrast, when the focus is cancer biology or its treatment, ONC could be appropriate.
With the Cardiovascular Sciences [CVS] IRG: There is shared interest in the areas of hypertensive disorders of pregnancy (including preeclampsia), maternal cardiac diseases, angiogenesis in placenta and uterine tissues, and fetal cardiovascular physiology and pathophysiology. Applications that directly relate to maternal or fetal cardiovascular physiology or disease could be referred to PN. Applications where the primary focus is systemic or regional circulation, hypertension or other aspects of angiogenesis or vascular cell biology may be assigned to CVS.
With the Digestive Sciences [DIG] IRG: There is shared interest in the areas of placental nutrient transport and fetal growth. (1) Applications specifically related to placental function and fetal nutrition could be referred to PN. Dietary and physiological influences on the handling of nutrients, pharmaceuticals or xenobiotics by the gastrointestinal tract may be assigned to DIG. (2) When the primary focus is hormones of the gastrointestinal tract and peptides and neurotransmitters of the brain-gut axis, applications could be assigned to DIG. Applications that focus on the interaction of GI hormones with placental hormones could be assigned to PN.
With the Respiratory Sciences [RES] IRG: There are shared interests in areas related to fetal and neonatal pulmonary development, physiology, pathophysiology, diseases and disorders. Applications dealing with effects of endocrine, metabolic, nutritional, or reproductive (pregnancy and fetal or neonatal well-being) factors on fetal or neonatal pulmonary development, physiology, pathophysiology, diseases and disorders, including Sudden Infant Death Syndrome (SIDS), could be assigned to PN. Applications that focus on physiological, cellular, or molecular aspects of pulmonary development or function or fetal and neonatal lung diseases and disorders could be assigned to RES. Applications that focus on pulmonary function in SIDS could also be assigned to RES.
With the Musculoskeletal, Oral, and Skin Sciences [MOSS] IRG: There are shared interests in the neonatology and development of the musculoskeletal, oral and skin systems. Studies that focus on the physiology or pathology of these systems could be referred to MOSS. Studies that focus on the maintenance of pregnancy or overall fetal well-being could be referred to PN.
With the Renal and Urological Sciences [RUS] IRG: (1) There is shared interest in the area of maternal renal diseases and hypertensive disorders of pregnancy (including preeclampsia). Applications that focus on conditions in the fetus or the pregnant female may be referred to PN. Studies that focus on renal hemodynamics, tubular function, and renal humoral/hormonal agents, as they affect renal function, may be assigned to RUS. Hypertension associated with renal insufficiency or end-stage renal disease may also be assigned to RUS. (2) Studies of female sexual medicine could be assigned according to the focus of the application, typically to PN. Studies of the male or female reproductive systems that focus on consequences to the kidney or the urinary tract, and urinary incontinence, could be assigned to RUS. (3) For proposals dealing with the fetal kidney, PN could be appropriate if the emphasis is fetal well-being or pregnancy. Other aspects of kidney development could be appropriate for RUS.
With the Surgical Sciences, Biomedical Imaging and Bioengineering [SBIB] IRG: There is shared interest in the area of fetal and maternal reproductive tract diagnostic imaging. Fetal and maternal studies that use documented imaging procedures, either in a research or clinical environment, could be appropriately reviewed in PN. Studies that focus on the development of imaging equipment or protocols could be referred to SBIB.
With the Molecular, Cellular, and Developmental Neuroscience [MDCN] IRG: There is shared interest in fetal brain development. Applications dealing with fetal brain development as it relates to pregnancy outcome or neonatal health could be assigned to PN. MDCN could be assigned applications addressing molecular and cellular aspects of brain development and function.
With the Integrative, Functional, and Cognitive Neuroscience [IFCN] IRG: There is shared interest in the areas of the endocrinologic aspects of pregnancy, pregnancy-related studies of pharmacology and toxicology, and fetal or neonatal growth and development. Applications focused on neural aspects of the behavioral effects of these processes could be assigned to IFCN. Applications focused on the processes themselves could be assigned to PN.
With the Brain Disorders and Clinical Neuroscience [BDCN] IRG: There is shared interest in the areas of fetal brain development, hypoxic encephalopathy and fetal brain function. Applications dealing with these areas, as they relate to pregnancy outcome or neonatal health could be assigned to PN, whereas, BDCN could be assigned applications addressing normal and pathologic brain development and function.