NIH-CSR <script type="text/javascript"> var wmNotice = "UNT Web Archive - External links, forms, and search boxes may not function within this collection. Url: http://cms.csr.nih.gov/PeerReviewMeetings/CSRIRGDescription/EMNRIRG/IPOD.htm time: 14:18:10 Sep 20, 2008"; var wmHideNotice = "hide"; var contextRoot = "https://webarchive.library.unt.edu/eot2008/"; </script> <script type="text/javascript" src="https://webarchive.library.unt.edu/eot2008/js/disclaim.js"></script> <span id="Postingname3_PostingDisplayName">Integrative Physiology of Obesity and Diabetes Study Section [IPOD]</span> (EMNRIRG)

[IPOD Roster]

The Integrative Physiology of Obesity and Diabetes study section [IPOD] may review applications dealing with any aspect of integrative physiology or whole organ cross talk in the setting of diabetes or obesity. All aspects of carbohydrate, lipid and energy utilization, storage and regulation in the setting of either diabetes or obesity are also reviewed by IPOD. Proposals examining the pathogenesis of obesity and diabetes in animal models may be referred to this study section as well.

Specific areas covered by IPOD:

Pathogenesis of obesity and diabetes: genetic effects, including maturity-onset diabetes of the young (MODY), Type 1 or 2 diabetes, mitochondrial genes and genes and genes affecting energy homeostasis and obesity.
Body composition and the mechanisms which regulate it, and the metabolic consequences of distribution patterns of adipose tissue.
Systemic regulation of insulin secretion and insulin action in liver, muscle, and fat.
Skeletal muscle biology pertaining to fuel metabolism, energy expenditure, accumulation of myocyte lipid, and possible secretory functions.
Mechanisms for sensing glucose and other nutrients in animal, tissue or cell models.
Adipocyte function, including nutrient storage and release and communication with other organs and tissues.
Mechanisms for regulating fuel homeostasis and the pathogenesis of obesity and diabetes, including: glucose and amino acid transport and metabolism; protein synthesis and degradation; fatty acid synthesis, transport, and oxidation; lipogenesis and lipolysis; glucose oxidation and glycogen synthesis; and gluconeogenesis.
Modulation of insulin action by cytokines and altered nutritional and metabolic states.
Mechanisms, genetic predictors, and the role of nutrients and diet in preventing complications of diabetes.
Central nervous system regulation of energy intake and expenditure and nutrient partitioning
Neural mechanisms for sensing glucose and other nutrients
Central nervous system effects and autonomic physiology related to energy metabolism on islet function and insulin action
Hypoglycemia and counter regulatory mechanisms
Effects of exercise physiology on treatment, prevention or consequences of obesity and diabetes

IPOD has the following shared interests within the EMNR IRG:

·         With Molecular and Cellular Endocrinology [MCE]: Polypeptide hormone synthesis, secretion, and trafficking are areas of shared interest with MCE. In general, studies of hormone synthesis, secretion, trafficking, and signal transduction are referred to MCE. However, if the primary focus is metabolic regulation or organ cross-talk with insulin signaling, the application could be referred to CIDO or IPOD. If the primary focus is islet or adipocyte hormone secretion, in the context of obesity or diabetes, applications could be referred to CADO, IPOD, or CIDO.

·         With Integrative and Clinical Endocrinology and Reproduction [ICER]: The study of Polycystic Ovarian Syndrome (PCOS) overlaps with ovarian dysfunction. When the application is focused on gonadal pathophysiology assignment could be to ICER. The application could be referred to CADO, IPOD, or CIDO when the focus is insulin resistance in PCOS.

·         With Pregnancy and Neonatology [PN]: An application could be referred to PN if it focuses primarily on placental biology, pregnancy complications, or immediate fetal or maternal outcomes. If it focuses on carbohydrate and lipid metabolism, insulin secretion or long-term diabetes outcomes, it could be referred to either CADO, IPOD, or CIDO.

·         With Cellular Aspects of Diabetes and Obesity [CADO]: Applications focusing on general carbohydrate, lipid, and/or protein metabolism in the context of obesity and diabetes may be assigned to IPOD. Applications where the focus is on beta cell biology and/or physiology, insulin signaling and action, and adipocyte biology/physiology may be assigned to CADO.

·         With Clinical and Integrative Diabetes and Obesity [CIDO]: CIDO and IPOD share conceptual and methodological interests. Applications where the focus is patient oriented research may be assigned to CIDO. Applications which use animal, tissue or cell models related to diabetes or obesity may be assigned to CADO or IPOD.

·         With Integrative Nutrition and Metabolic Processes [INMP]: Applications focusing on lipoproteins or lipid metabolism could be referred to INMP. Applications focusing on basic aspects of metabolic regulation related to obesity or diabetes could be referred to CADO, IPOD, or CIDO.

IPOD has the following shared interests outside the EMNR IRG:

·         With the Genes, Genomes, and Genetics [GGG] IRG: Genetics of obesity and diabetes may be areas of shared interest with GGG. Models of the complex genetic questions and mapping in animals or humans could be referred to GGG. Analysis of the functional consequences of specific genetic alterations concerning obesity and/or diabetes could be referred to CADO, IPOD, or CIDO. Genomic approaches to the molecular physiology of obesity and/or diabetes should be assigned in a manner consistent with the main focus of the application. If genomic tools (e.g., DNA or protein microarrays, high throughput sequencing, SNP detection, bioinformatics) are used primarily to address questions regarding the physiology/pathogenesis of these states, the application could be referred to CADO, IPOD, or CIDO. If a major focus is development of genomic techniques/materials for the study of these phenotypes, the application could be referred to GGG.



·         With the Biology of Development and Aging [BDA] IRG: There may be shared interests in the area of aging research. Studies of metabolic regulation related to obesity and diabetes, regulation of nutrient flux and metabolism, and adipocyte biology could be referred to CADO, IPOD or CIDO. BDA may review applications with a primary emphasis on aging issues (i.e., on the role of aging changes or co-morbidity-related factors affecting pathogenesis of diabetes and obesity in the elderly) when the study transcends a single organ system or discipline. BDA could also review applications that focus on the effects of diabetes and obesity on pathophysiologic processes in the elderly when the study transcends a single organ system or discipline.

·      With the Bioengineering Sciences and Technologies [BST] IRG: Shared interest exists in the measurement of intracellular and physiological levels of glucose and other metabolites. Applications that propose the development of new sensor technology are appropriate for BST; studies that use the instrumentation to monitor metabolite levels are appropriate for CADO, IPOD, or CIDO.

·         With the Risk, Prevention and Health Behavior [RPHB] IRG: Shared interest exists regarding the metabolic regulation of obesity, diabetes, and insulin secretion and action. Applications that utilize methodologies focusing on regulation at the cellular and molecular level could be assigned to CADO, IPOD, or CIDO. Applications that focus on modification of individual behaviors, attitudes, psychosocial supports and resources as they affect prevention or treatment of obesity, diabetes, and insulin secretion and action could be assigned to RPHB. Applications that focus on human behavior as a risk factor for and as prevention of obesity, or to moderate energy expenditure and food intake could be assigned to RPHB.

·         With the Oncological Sciences [ONC] IRG: Obesity or insulin resistance as a risk factor for cancer is an area of shared interest with ONC. If the primary focus is oncogenesis the application could be referred to ONC. If the focus is mechanisms related to metabolic fuel homeostasis, glucose homeostasis or insulin action on cell growth, it may be referred to CIDO, IPOD, or CADO.   Applications that explore the relationship between insulin/IGF signaling and cancer of endocrine or neuroendocrine tissues could be referred to CIDO, CADO, or IPOD.

·         With the Cardiovascular Sciences [CVS] IRG: In general, applications that focus on the biology or pathogenesis of obesity could be referred to CIDO or IPOD. Applications that focus on the cardiovascular effects of obesity, e.g., left ventricular hypertrophy (LVH) or end stage arterial disease may be referred to CVS.

·         With the Musculoskeletal, Oral and Skin Sciences IRG [MOSS] IRG: Applications dealing with exercise may be an area of shared interest with the MOSS IRG. If the application primarily deals with the effects of exercise on the treatment, prevention or consequences of obesity and diabetes or insulin action, it could be assigned to IPOD.   Proposals that focus primarily upon glucose and lipid metabolism in, or the effects of obesity, diabetes, or dietary changes on skeletal muscle, whole body, or multiple organ systems may be appropriate for IPOD or CIDO. Applications dealing primarily with the effects of exercise on skeletal muscle mass, function, or metabolism could be referred to MOSS.

·         With the Digestive Sciences [DIG] IRG: There is shared interest in the area of cholesterol metabolism and complications of diabetes. Applications dealing primarily with lipid metabolism in the liver as it relates to Non-Alcoholic Fatty Liver Disease (NAFLD) could be assigned to DIG, while applications focusing on lipoproteins, lipid metabolism and diabetic complications could be assigned to CADO, IPOD, or CIDO.

·         With the Respiratory Sciences [RES] IRG: There is shared interest with areas related to obesity. Applications that have a focus on obesity in general, or on the genetics of obesity, but without a specific focus on sleep apnea or upper airway physiology, could be assigned to CIDO or IPOD. Similarly, applications that have a focus on metabolic syndrome in general, but without a major focus on obstructive sleep apnea, may be referred to CIDO or IPOD . Applications related the impact of obesity on upper airway physiology (most notably, obstructive sleep apnea), on chest wall mechanics, or on asthma or other airways diseases could be assigned to RES. Similarly, applications related to leptin in the context of control of breathing or obstructive sleep apnea could be assigned to RES.

·       With the Renal and Urological Sciences [RUS] IRG:  Applications that focus on the effects of nutrient metabolism in diabetic nephropathy and diabetes-induced metabolic abnormalities may be referred to IPOD or CIDO. RUS could be assigned applications on renal transport mechanisms intrinsic to diabetic nephropathy, diabetes-induced renal pathology, and diabetes-induced urologic pathology.

·         With the Molecular, Cellular, and Developmental Neuroscience [MDCN] IRG: Cellular and molecular studies that focus on diabetic neuropathy may be referred to MDCN; studies that focus on diabetes may be referred to CADO, IPOD, or CIDO.