Molecular and Integrative Signal Transduction study section [MIST]

[MIST Roster]

 

The Molecular and Integrative Signal Transduction (MIST) study section will review applications that focus broadly on basic molecular mechanisms of signaling among cells. These applications will focus on the biochemical and structural mechanisms of signal transduction, including G-proteins, seven-transmembrane protein (7TM) coupled receptors, and their regulation. Further, the associated kinases, phosphatases and lipid signaling mechanisms and cross-talk with other pathways are of interest. Integrative studies may involve a variety of organisms that advance the field whether uni- or multi-cellular, bacterial or mammalian.

 

Specific areas include:

 

  • Biochemical and structural mechanisms of receptor signal
    transduction, including G-proteins and 7TM receptors
  • Molecular mechanisms of protein-protein interactions among signaling molecules
  • Serine and tyrosine protein kinases associated with signal transduction mechanisms
  • Protein phosphatases associated with signal transduction mechanisms
  • Second messenger mechanisms including lipid signaling molecules
  • Related metabolic studies including drugs and inhibitors
  • Regulatory mechanisms controlling signaling including regulator of G-protein signaling (RGS) proteins
  • Computer simulations and modeling of signaling complexes and pathway components

The MIST Study Section has the following shared interests within the CB IRG:

 

With the CSRS Study Section:  Cell signaling is an area of shared interest. Applications focused on biochemical and molecular mechanisms of G-protein and 7TM receptors could be reviewed by MIST. Those with an emphasis on signaling networks and the coordination of processes related to the cell cycle, proliferation, survival and growth could be reviewed by CSRS.

 

With the CSF Study Section: Cell signaling mechanisms are an area of shared interest. Applications focused on the translocation or recycling of signaling receptors and molecules could be reviewed in CSF. Those focused on molecular and biochemical aspects of signal transduction could be reviewed in MIST.

 

With the ICI Study Section: Receptor signal transduction mechanisms are an area of shared interest. Applications focused on crosstalk by adhesion receptors and other signaling pathways could be reviewed in ICI. Those focused on general molecular and biochemical aspects of signal transduction pathways could be reviewed in MIST.

 

With the MBPP Study Section: Cell signaling mechanisms including lipid signaling are an area of shared interest. Applications focused on the translocation or recycling of signaling molecules or complexes could be reviewed in MBPP. Those focused on general molecular and biochemical aspects of signal transduction pathways could be reviewed in MIST.

 

With the NDT Study Section: Cell signaling mechanisms are an area of shared interest. Applications focused on signaling mechanisms and networks that target the nucleus could be reviewed by NDT. Those focused on molecular and biochemical aspects of cytoplasmic signal transduction could be reviewed in MIST.

 

 

The MIST Study Section has the following shared interests outside the CB IRG:


With the Bioengineering Sciences and Technologies [BST] IRG
: Shared areas of interest are computational biology and cell imaging.  If the focus is on the development of new imaging technologies or computational methods, the assignment could be to BST. If the focus is the use of imaging technologies or computational methods to answer questions related to signaling complexes and pathway components, assignment could be to MIST. An application that combines bioengineering and cell biology could be assigned according to the focus of the research.

With the Biological Chemistry and Macromolecular Biophysics [BCMB] IRG: Shared areas of interest are protein-ligand interactions, drug discovery and macromolecular studies of metabolic pathways and networks. If the focus is on high resolution structural, synthetic or biophysical studies of these systems, assignment could be to BCMB. If the focus is on the functional and mechanistic or biochemical studies of these systems, or on G-protein receptors, assignment could be to MIST.

With the Cardiovascular Sciences [CVS] IRG: Shared areas of interest are the regulation and signaling of adrenergic and other G-protein coupled receptors. If the focus is on the physiological question related to hypertension, regional and microcirculation, or lymphatic flow, assignment could be to CVS. If the focus is on a fundamental cellular and molecular understanding of the regulation and signaling of adrenergic receptors and other G-protein coupled receptors, including the activation and regulation of the relevant phospholipases, kinases, phosphatases and cyclases, assignment could be to MIST. 

With the Oncological Sciences [ONC] IRGShared areas of interest are signal transduction pathways mediated by phosphatases and other proteins. If the main focus is on cancer biology or oncogenic transformation, assignment could be to ONC. If the scientific question is focused on basic mechanistic studies or elucidation of fundamental signal transduction complexes, using cancer as a model system, assignment could be to MIST.

With the Immunological Sciences [IMM] IRG: Shared areas of interest are intracellular signaling and the biochemistry of second messengers including lipid mediators and reactive nitrogen and oxygen species. If the scientific focus is on an immunological question, assignment could be to IMM. If cells of the immune system are used as a model system to elucidate fundamental signal transduction mechanisms, assignment could be to MIST.



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