The Acute Neural Injury and Epilepsy [ANIE] Study Section addresses the anatomical, cellular and functional basis of neural disease and injury across the life span.  Emphasis is on the neural substrate, functional consequences [sensory/motor, behavioral, pathophysiological], rehabilitation, and the development of therapeutic strategies for acute neurological disorders, particularly stroke/ischemia, epilepsy, spinal cord injury and traumatic brain injury. This Study Section considers patient-oriented research and animal models.

Specific areas covered by ANIE:

• Anatomical, neuropathological, neuroimaging, electrophysiological, functional mapping, and autopsy studies to monitor the onset, progression and treatment of brain and spinal cord disease and injury; therapeutic approaches and clinical studies; cerebral blood flow and metabolism in the context of clinical neuroimaging.
• Functional and anatomical changes in sensory and motor systems associated with the initiation, progression, and treatment of neural injury.
• Changes in functional domains that are consequences of disease and injury; strategies for therapeutic intervention.
• Cellular, anatomical, and systems-based studies of changes in the neural substrate and function of brain and spinal cord in response to disease and injury.
• Recovery of function/rehabilitation; beneficial and compensatory changes in the neural substrate in response to clinical interventions; neurological and functional evaluation of neural prostheses, electrical/magnetic stimulation, behavioral and pharmacological interventions, and physical therapy.
• Evaluation of pharmacological, transplantational, surgical, electrophysiological, physical or behavioral interventions to reduce loss, enhance function, and facilitate recovery.

ANIE has the following shared interests within the BDCN IRG: 

• With Brain Injury and Neurovascular Pathologies [BINP]: Studies focused on genetic, molecular and cellular basis of acute brain injury and related vascular pathologies are reviewed in BINP. ANIE would be more appropriate to review the clinical facets of the same.
• With Clinical Neuroimmunology and Brain Tumors [CNBT]: CNBT reviews studies focused on immune, inflammatory and vascular mechanisms, while ANIE reviews the anatomical and functional basis of neural disorders and injury, including functional imaging studies.
• With Clinical Neuroplasticity and Neurotransmitters [CNNT]: Brain imaging studies that focus on specific neurotransmitter systems and receptors are reviewed in CNNT, while more general brain imaging studies of neuropathological pathways and brain dysfunction are reviewed in ANIE.
• With Developmental Brain Disorders [DBD]: DBD reviews studies of neurodevelopmental disorders, especially when the focus is on unique aspects of the developing nervous system. Neuroanatomical and functional disease processes that are common to children and adults may be reviewed in ANIE.
• With Clinical Neuroscience and Neurodegeneration [CNN]: CNN reviews studies focusing on chronic and neurodegenerative conditions. ANIE reviews studies that focus on acute nervous system injury and epilepsy. Cognitive impairment associated to acute injury may be reviewed in ANIE. 

ANIE has the following shared interests outside the BDCN IRG:

• With the Biobehavioral and Behavioral Processes [BBBP] IRG: Studies that focus primarily on behavior and behavioral approaches to neural injury and disease may be reviewed in the BBBP IRG. Studies that focus mainly on the anatomical and functional basis of the disorders could be reviewed in ANIE.
• With the Biology of Development and Aging (BDA) IRG:  The BDA IRG has shared interests with ANIE in neurological diseases, their therapeutic approaches and clinical studies.  Studies with a primary focus on specific neurological diseases could be reviewed in ANIE.  Studies focused on multiple system manifestations of neurological diseases occurring specifically in aging human or animal subjects and that may require integrated experimental, genetic or observational approaches may be more appropriate for BDA.

• With the Cardiovascular Sciences [CVS] IRG: Studies dealing with cerebral circulation and hemodynamics may be assigned to the CVS IRG, while those focusing on cerebral blood flow and metabolism in the context of neuroimaging for analysis of brain and spinal cord disease or injury or the functional consequences of ischemia, hypoxia, stroke on brain or spinal cord function could be assigned to ANIE.

• With the Emerging Technologies and Training in Neuroscience [ETTN] IRG: Studies on brain disorders and treatment are shared interests with ETTN. If the focus is on basic genetic mechanisms associated with neural dysfunction or technological developments, assignment could be to ETTN. If the focus is a clinical study or a response to drugs in model systems, assignment could be to ANIE.
• With the Genes, Genomes and Genetics [GGG] IRG: The GGG IRG has shared interests with ANIE with respect to diseases of the nervous system.  When the focus is primarily on molecular genetic approaches, large-scale gene/genomic/genetic studies and gene discovery using complex or novel technologies, the application may be reviewed in the GGG IRG. Studies that include genetics but focus primarily on the anatomical, functional and pathologic basis of the neural injury may be reviewed in ANIE.
• With the Health of the Population (HOP) IRG:  HOP and ANIE have shared interests in neural injury and epilepsy, including stroke and TBI. Studies dealing with descriptive and analytic aspects of behavioral, environmental or genetic risk and/or protective factors in population-based or clinically-ascertained samples could be reviewed by the HOP IRG, while studies on the neural basis of these disorders in patients/small populations could be reviewed within ANIE.
• With the Integrative, Functional, and Cognitive Neurosciences [IFCN] IRG: Studies that focus primarily on understanding the neurobiological basis of sensory/motor processes may be reviewed in the IFCN IRG. Studies that focus on the sensory/motor consequences of neurological disorders or neural injury could be reviewed in ANIE.
• With the Musculoskeletal, Oral and Skin Sciences [MOSS] IRG: ANIE has shared interests within the MOSS IRG with respect to research on recovery and rehabilitation. While MOSS focuses broadly on physical therapy, physiology, and non-neuronal systems, ANIE has a particular focus on the neural basis of rehabilitation and recovery.
• With the Molecular, Cellular, Developmental Neuroscience [MDCN] IRG:  MDCN and ANIE share a common interest in neurologic diseases.  However, MDCN focuses largely on basic cellular and molecular processes whereas ANIE reviews studies related to the cellular, anatomical and functional aspects of these diseases within a clinical context.
• With the Surgical Sciences, Biomedical Imaging and Bioengineering [SBIB] IRG:  ANIE and the SBIB IRG review studies dealing with functional brain imaging; however, ANIE may review those studies using imaging as a tool to study neurological disorders or injury or their treatment. SBIB may review studies concerning the development and evaluation of imaging procedures.  SBIB is appropriate for studies with focus on the development of imaging technology. However, if the proposed research is more oriented toward the application of imaging techniques for studying injury or their treatment, ANIE may be more appropriate to review the application.