[SBCA Roster]   [SBCB Roster]

These study sections review research activities central to biology and medicine in which chemical synthesis, molecular structure, and reaction mechanism have central roles.  The SBCA and SBCB study sections review applications in synthetic and biological chemistry ranging from fundamental to applied research.  The SBCA and SBCB study sections both integrate synthetic methods and target directed synthesis with chemical biology and medicinal chemistry. 

Specific areas covered by SBCA and SBCB:

• Bioinorganic and bioorganic /chemical biology
  Discovery, invention, and application of synthetic chemistry and reagents to problems in biology.
  
  
• Drug design/medicinal chemistry
  The design and synthesis of novel molecules that modulate biochemical processes of potential clinical relevance, including the study of physiochemical, ADME (absorption, distribution, metabolism, excretion), pharmacokinetic, and pharmacological properties.
  
  
• Enzymology
  Studies of enzymes that focus predominantly on the design and synthesis of drugs or compounds with pharmaceutical potential.
  
  
• Synthetic methods
  Discovery and development of strategies, reactions, reagents, and catalysts for use in synthesis.
  
  
• Target-directed synthesis
  Total synthesis of natural products and other biologically interesting targets of defined structure.

Additional areas for SBCA may include include:

• Bioconjugate chemistry: The attachment of active molecules to biopolymers, including proteins, nucleic acids, polysaccharides, and lipids.
  
  
• Biomaterials: The synthesis and study of polymers, molecular assemblies, and nanostructured materials of potential use in biological systems and medicine.
  
  
• Biomimetic chemistry: Development of molecules with structures and functions based on extrapolation from biological examples.
  
  
• Imaging agents: Synthesis of molecules to improve the detection of cellular processes and structures and diagnosis of disease states.
  
  
• Inorganic and organic reactions and mechanisms: Fundamental studies of chemical reactivity of biological relevance.
  
  
• Metals in chemistry: Investigation of the roles, both natural and designed, of metal ions in chemical structure and function.
  
  
• Molecular recognition: Elucidation of inter- and intramolecular noncovalently controlled phenomena of chemical and biological relevance.
  
  
• Molecular design: The use of biological molecules or their analogs as fundamental building blocks for the synthesis of compounds with novel functions.

Additional areas for SBCB may include include:

• Biosynthetic pathways: Elucidation and manipulation of the pathways by which primary and secondary metabolites are produced, including chemical strategies for combating infective agents and disease vectors.
  
    
• Diversity oriented synthesis: Development and application of synthetic strategies for the preparation of structurally diverse compounds and compound libraries of potential utility. 
  
  
• Natural Products Discovery: Isolation and characterization of compounds of potential importance to human medicine from terrestrial and aquatic microbiological, plant, and animal sources.

The SBC Study Sections have the following shared interests within the BCMB IRG:

• With Synthetic and Biological Chemistry A and B [SBCA & SBCB]: SBCA and SBCB share interest in synthetic chemistry such that applications concerned with development of synthetic methods and total synthesis may be assigned equally to either study section. Although both study sections share interests in bioinorganic and medicinal chemistry, SBCA could be assigned applications with emphasis on bioconjugates, biomaterials, biomimetics, metals, and imaging. SBCB could be assigned applications with emphasis on bioorganic chemistry, biosynthetic pathways, and chemical diversity.
  
  
• With Macromolecular Structure and Function A [MSF-A]:  The SBCA and SBCB study sections have shared interests in structure- and mechanism-based drug design with the MSFA study section.  Applications that emphasize synthetic or medicinal chemistry may be assigned to SBCA or SBCB.  Applications that emphasize biochemical, structural, mechanistic or computational approaches may be assigned to MSFA.  
  
  
• With Macromolecular Structure and Function B [MSFB]:  The SBCA study section has shared interests in peptide, protein, and nucleic acid design with MSFB. Applications that emphasize chemical synthesis or drug design may be assigned for review by SBCA. Applications that emphasize macromolecular structure or function may be assigned for review by MSFB.
  
  
• With Macromolecular Structure and Function C [MSFC]:  The SBCA study section has shared interests in imaging agents and approaches with MSFC. Applications that emphasize chemical synthesis or design of imaging agents may be assigned for review by SBCA. Applications that emphasize application of imaging agents to macromolecular structure or function may be assigned for review by MSF-C (or -A or- B as appropriate).
  
  
• With Macromolecular Structure and Function A, B, and C [MSFA, MSFB, & MSFC]:  The SBCA and SBCB study sections have shared interests with MSFA, MSFB, and MSFC in development and analysis of inhibitors of macromolecular interactions (protein-protein, protein-nucleic acid, etc.).  Applications that emphasize inhibitor synthesis or design could be assigned to SBCA or SBCB. Applications that emphasize macromolecule and inhibitor interactions or functions could be assigned to MSFA, MSFB, or MSFC.
  
  
• With Biochemistry and Biophysics of Membranes [BBM]:  The SBCA study section has a shared interest in development of reagents for manipulation and crystallization of membrane proteins with the BBM study section.  Applications that are more synthetically oriented may be appropriate for SBCA. Applications that are more structurally oriented may be appropriate for BBM. The SBCA and SBCB study sections have shared interests in enzymology with BBM. Applications with emphasis on enzymes that are potential targets for drug design and approach these targets using medicinal/synthetic chemistry methodologies may be assigned to SBCA or SBCB.  Studies with emphasis on membrane enzymes as potential targets for drugs and approach these targets using biochemical, structural or computational methodologies may be assigned to BBM.
  
  
• With Enabling Bioanalytical and Biophysical Technologies [EBT]:  Combinatorial chemistry and novel materials are shared interests. If the emphasis is synthetic chemistry, then assignment could be to SBCA or SBCB. If the emphasis is analytical chemistry, then assignment could be to EBT.

The SBC Study Sections have the following shared interests outside the BCMB IRG:

• With the Genes, Genomes, and Genetics [GGG] IRG:  SBCA and SBCB share interests with the GGG IRG in the area of small molecule regulation of gene expression.  If emphasis is on the chemistry or design of small molecule regulators, then assignment could be to SBCA or SBCB. If emphasis is on genetic aspects of expression, then assignment could be to GGG.
  
  
• With the Bioengineering Sciences and Technologies [BST] IRG: SBCA and SBCB share interests with the BST IRG in the areas of biomaterials, imaging agents, gene delivery strategies, and molecular design.  Applications focusing on chemical aspects of these topics could be assigned to SBCA or SBCB.  Applications focusing on bioengineering aspects could be assigned to BST.
  
  
• With the Immunology [IMM]; Infectious Diseases and Microbiology [IDM]; AIDS and Related Research [AARR]; Oncological Sciences [ONC]; Hematology [HEME]; Cardiovascular Sciences [CVS]; Endocrinology, Metabolism, Nutrition, and Reproductive Sciences [EMNR]; Musculoskeletal, Oral and Skin Sciences [MOSS]; Digestive Sciences [DIG]; Respiratory Sciences [RES]; Renal and Urological Sciences [RUS]; and the Brain Disorders and Clinical Neuroscience [BDCN] IRGs: The SBCA and SBCB study sections have shared interests in drug design and medicinal chemistry with the organ and disease-oriented IRGs.  Applications that emphasize early drug discovery (hit to lead and lead optimization) could generally be assigned to SBCA and SBCB.  Studies that emphasize candidate selection, preclinical and clinical evaluation could be assigned to the organ and disease-oriented IRGs.
  
  
• With the Surgical Sciences, Biomedical Imaging and Bioengineering [SBIB] IRG: SBCA and SBCB share interests with the SBIB IRG in the areas of biomaterials and imaging agents.  Applications emphasizing chemical aspects of these topics could be assigned to SBCA or SBCB.  Applications emphasizing medical bioengineering aspects could be assigned to SBIB. 

[MSFA Roster] [MSFB Roster] [MSFC Roster] [MSFD Roster] [MSFE Roster]

The Macromolecular Structure and Function [MSF] Study Sections review applications that focus on the biochemistry and biophysics of sequence-structure-function relationships in proteins, nucleic acids, carbohydrates, their complexes, and interactions with small molecules. Experimental approaches include physical and chemical methods to study interactions between molecules. A broad range of theoretical and computational approaches as well as kinetic, mechanistic, and thermodynamic characterizations of biomolecules and their functions are included. The emphasis is on the application of these and other biochemical and biophysical methods to problems of biological relevance.

A large number of applications fall naturally into the Macromolecular Structure and Function study sections. Metallobiochemical applications, in a broad sense, including such topics as metals in biology, chemical reactions and mechanisms, imaging agents, and molecular design, may be clustered in MSFA. In addition, glycobiology applications may be clustered in MSFB, and protein-protein and macromolecular assembly interactions may be clustered in MSFC. Crystallographic studies should be at home in any of the three study sections.

Specific areas covered by MSFA, MSFB, MSFC, MSFD &MSFE:

• Macromolecular structure-function relationships and related structural biology
• Protein, nucleic acid, and carbohydrate structures
• Enzymology, including inhibitors and metabolism
• Protein-ligand interactions, including receptors and signal transduction
• Macromolecular interactions and regulatory mechanisms
• Computational, theoretical, and experimental studies

Additional areas for MSFA may include:

• Metalloenzymes, inhibitors, and their mechanisms
• Metalloproteins and related inorganic reactions
• Biophysics of enzymes, metals, and cofactors
• Chemistry of reactive oxygen metabolism
• Synthetic and theoretical models of metallo-active sites
• Application of quantum mechanics and molecular mechanics to metals in macromolecules
• Metal ion homeostasis and metabolism

Additional areas for MSFB may include:

• Protein structure, dynamics, and function
• Structure determination and application of biophysical theory for protein folding
• Mechanisms of protein and nucleic acid folding and misfolding
• Post-transcriptional and post-translational modifications, including glycobiology
• Protein and nucleic acid design
• Structure prediction and conformational dynamics

Additional areas for MSFC may include:

• Macromolecular assemblies
• Mechanisms of allostery
• Protein-nucleic acid interactions
• Structural biology of signal transduction including specificity issues related to in vivo conditions
• Energy-dependent conformational changes including molecular motors, ATPases, and macromolecular machines
• Protein-ligand, protein-protein interactions, and protein interaction networks
• Biophysical studies of muscle structure and function
• Single molecule investigations

Additional areas for MSFD may include:

• Computational analysis, annotation, and scientific visualization pertaining to macromolecular biophysics
• Sequence-structure-function relationships and prediction of macromolecular function
• Molecular modeling of three-dimensional structures, interactions, and ligand-macromolecule interactions
• Biophysical theory of macromolecular structure and function, and prediction of macromolecular interactions at different resolutions
• Development of new biophysical theories and complementary computational and experimental approaches
• Biophysical simulations and experimental validations

Additional areas for MSFE may include:

• Mechanistic enzymology involving protein and nucleic acid catalysts
• Protein-ligand interactions and dynamics
• Inhibitors of enzymes and their mechanisms
• Drug chemistry and metabolizing enzymes
• Macromolecular studies of metabolic pathways and networks
• Computational and mechanism-based drug design
• Application of quantum mechanics and molecular mechanics to studies of enzyme mechanisms

 The MSF Study Sections have the following shared interests within the BCMB IRG:

• With Synthetic and Biological Chemistry [SBCA & SBCB]:  The SBCA and SBCB study sections have shared interests in structure- and mechanism-based drug design with the MSFA and MSFE study sections.  Applications that focus on synthetic or medicinal chemistry may be assigned to SBCA or SBCB.  Applications that focus on biochemical, structural, mechanistic or computational approaches may be assigned to MSFA or MSFE.
  
  
• With Biochemistry and Biophysics of Membranes [BBM]:  Studies of membrane-bound enzymes may be considered by MSFA if the primary emphasis is on chemical mechanisms, otherwise they may be considered by BBM. Investigations of soluble domains of membrane-bound proteins (including receptors) may be reviewed by MSFC if the primary emphasis is on their extra-membrane function. Lipid simulations and theoretical studies of membrane proteins may be assigned to MSFD. Glycobiology applications may also be assigned to either BBM or MSFB.
  

The MSF Study Sections have the following shared interests outside the BCMB IRG:

• With the Genes, Genomes, and Genetics [GGG] IRG:  The MSF Study Sections share interests with the GGG IRG in the area of structural and mechanistic investigations of gene function. If the focus is on structural and mechanistic investigations of gene function that are making use of emerging biophysical methodologies, then appropriate assignment may be to one of the MSF study sections. If focus is on genetic aspects of gene function, then assignment may be to GGG. 
  
• With the Cell Biology [CB] IRG:  The MSF Study Sections share interests with the CB IRG in the area of cell function. Applications that focus on biophysical questions may be appropriate for one of the MSF study sections. Applications that focus on cell biological questions may be appropriate for one of the CB study sections, e.g., Cell Structure Function.
  
• With the Bioengineering Sciences and Technologies [BST] IRG: The MSF Study Sections share interests with the BST IRG in computational methods. Applications in computational science that directly relate to scientific problems in chemistry, biological chemistry, and biophysics may be appropriate for the MSF study sections. Applications where the focus is more on the information sciences, database development, or software engineering may be appropriate for BST.
  
  
• With the Biology of Development and Aging [BDA]; Immunology [IMM]; Infectious Diseases and Microbiology [IDM]; AIDS and Related Research [AARR]; Oncological Sciences [ONC]; Hematology [HEME]; Cardiovascular Sciences [CVS]; Endocrinology, Metabolism, Nutrition, and Reproductive Sciences [EMNR]; Musculoskeletal, Oral and Skin Sciences [MOSS], Digestive Sciences [DIG], Respiratory Sciences [RES], Renal and Urological Sciences [RUS], and the Molecular, Cellular, and Developmental Neuroscience [MDCN] IRGs: Applications with an organ or disease focus may be of interest to the MSF Study Sections, particularly in the areas of structure determination, drug design, and medicinal chemistry. For applications with focus on questions of the specific organ or disease, including preclinical and clinical studies, assignment to the organ or disease IRGs may be appropriate. For applications with focus on basic questions of structure determination or early drug discovery (hit to lead and lead optimization), assignment to one of the MSF Study Sections may be appropriate.

[BBM Roster]

The BBM Study Section will consider research applications focused on all biochemical and biophysical aspects of membrane structure and function.  Cell membranes play a vital role in many areas of cell biology, which means considerable overlap with cell biology-related IRGs.  The distinguishing characteristic of applications reviewed by the BBM study section is a direct focus on the molecular details of processes that occur on or within membranes.  Areas include the use of a variety of biochemical and biophysical techniques to understand the structure and function of membranes. 

Specific areas covered by BBM include:

• Membrane architecture
• Membrane protein folding, assembly, and dynamics
• Membrane protein structure
• Methods for membrane protein structure determination, including crystallization
• Membrane-based energy transduction
• Function of transporters, channels, receptors, and membrane-bound enzymes
• Enzyme mechanism within membranes and interfaces
• Lipid metabolism and function
• Biophysics of membrane interfaces and signaling
• Lipid-protein interactions
• Biophysics of membrane fusion mechanisms
• Computational and modeling approaches to membranes and membrane proteins
• Structure of membrane glycoproteins and glycolipids

BBM has the following shared interests within the BCMB IRG:

• With Synthetic and Biological Chemistry [SBCA & SBCB]:  The SBCA and SBCB study sections have shared interests in enzymology with the BBM study section.  Applications that focus extensively on enzymes that are potential targets for drug design and approach these targets using medicinal/synthetic chemistry methodologies may be assigned to SBCA or SBCB.  Studies that focus on membrane enzymes as potential targets for drugs and approach these targets using biochemical, structural or computational methodologies may be assigned to BBM. 
  
  
• With Macromolecular Structure and Function A [MSFA]: Enzyme mechanisms are a shared interest.  If the study of an enzyme mechanism does not take place within membranes or at membrane interfaces, assignment for review may be to MSFA. If the study involves an enzyme mechanism within or at the surface of a membrane, assignment for review may be to BBM.
  
  
• With Macromolecular Structure and Function B [MSFB]: Protein folding is a shared interest.  If applications concern folding processes or structures of domains of membrane associated-proteins that do not specifically involve membrane components, they may be assigned to MSFB. If applications concern folding processes that occur in membranes or aspects of macromolecular domain structure related to signaling through the membrane, they may be assigned to BBM.
  
  
• With Macromolecular Structure and Function C [MSFC]: Investigations of soluble domains of membrane-bound proteins (including receptors) may be reviewed by MSFC if the primary emphasis is on their extra-membrane function.
  
  
• With Enabling Bioanalytical and Biophysical Technologies [EBT]:  Studies of methods development are a shared interest. Applications focused on development of methods with general applicability could be assigned to EBT. Applications focused on development of methods for membrane protein structure determination, including crystallization, could be assigned to BBM.

BBM has the following shared interests outside the BCMB IRG:

• With the Cell Biology [CB] IRG:  Molecular studies of membrane, protein, and organelle trafficking are shared interests between the CB IRG and the BBM study section. Applications that focus on the cell biology of membrane and protein trafficking, transport, and organelles could be referred to the CB IRG.  Applications that focus on biochemical and biophysical aspects of these processes could be referred to the BBM study section.
  
  
• With the Immunology [IMM]; Infectious Diseases and Microbiology [IDM]; AIDS and Related Research [AARR]; and the Molecular, Cellular, and Developmental Neuroscience [MDCN] IRGs: Membrane biochemistry and protein-protein interactions between cells and channels are shared interests with these IRGs and the BBM study section.  If an application focuses on an immunological, infectious disease, or neuroscientific question, then assignment to the appropriate organ or disease IRG may be appropriate. If an application focuses on biochemical or biophysical principles of membrane components, then assignment to BBM may be appropriate.

[EBT Roster]

The EBT study section will consider applications (R01, R21, SBIR/STTR, etc.) focused on the development of new bioanalytical and biophysical tools, emerging techniques, and instruments.  The goal of these will be to probe the molecular aspects of biological systems.  Both hypothesis driven and non-hypothesis driven applications are expected.  Many of these applications will explore either novel technologies or improvements to existing techniques such as improved resolution, sensitivity, throughput, and the fundamental underpinnings of these techniques.

Specific areas covered by EBT include:

• Bioanalytical techniques such as sensors, separations, mass spectrometry, spectroscopy, arrays, microfluidics, and novel assays.
• Biophysical techniques such as magnetic resonance techniques; optical, electron and x-ray microscopy; x-ray and neutron techniques.
• Novel materials, reagents, and surface chemistries related to either bioanalytical or biophysical methods, including nanotechnology.
• Software development applied to bioanalytical instrumentation, instrumentation control, data reduction, data analysis, or data mining.
• The feasibility of recently introduced technologies to examine and explore biological systems (for example, proteomics, genomics, metabolomics, sequencing, screening, characterizing macromolecular interactions, or clinical applications) both in vivo and in vitro.

EBT has the following shared interests within the BCMB IRG:

• With Synthetic and Biological Chemistry A and B [SBCA and SBCB]: Combinatorial chemistry and novel materials are shared interests. If the focus is synthetic chemistry, then assignment could be to SBCA or SBCB. If the focus is analytical chemistry, then assignment could be to EBT.
  
  
• With Macromolecular Structure and Function C [MSFC]: Single molecule biophysics is a shared interest.  Applications for instrument or technique development in this area could be assigned to EBT.  Applications that use single molecule techniques to study biological systems could be assigned to MSFC.
  
  
• With Macromolecular Structure and Function A, B, & C (MSFA, MSFB, & MSFC): The development of biophysical techniques is a shared interest.  Applications focused on initial development could be assigned to EBT.  As the technique matures and as the biological applications become obvious, applications could be assigned to MSFA, MSFB, or MSFC.
  
  
• With Biochemistry and Biophysics of Membranes [BBM]:  Studies of methods development are a shared interest. Applications focused on development of methods with general applicability could be assigned to EBT. Applications focused on development of methods for membrane protein structure determination, including crystallization, could be assigned to BBM.

EBT has the following shared interests outside the BCMB IRG:

• With the Genes, Genomes, and Genetics [GGG] IRG:  The EBT study section shares interests with the GGG IRG in the area of tools for probing single nucleotide polymorphisms, arrays, and sequencing.  An application with focus on the development of new fundamental tools in these areas could be assigned to EBT. An application with focus on the genetic aspects of tool development could be assigned to the GGG IRG.
  
  
• With the Bioengineering Sciences and Technologies [BST] IRG: The EBT study section shares interests with the BST IRG in the development of new tools. Applications in this area that focus on chemistry or biophysics could be assigned to EBT. Applications in this area that focus on bioengineering or biomaterials could be assigned to the BST IRG.  Applications developing technologies for use in proteins are well suited for EBT and applications developing technologies aimed at nucleic acids are well suited for BST.
  
  
• With the Immunology [IMM]; Renal and Urological Sciences [RUS]; Molecular, Cellular, and Developmental Neuroscience [MDCN]; Integrative, Functional, and Cognitive Neuroscience [IFCN]; and the Brain Disorders and Clinical Neuroscience [BDCN] IRGs: EBT shares interests with all of these IRGs in developing new tools and techniques.  An application with emphasis on the development of a new tool or technique at the chemical or biophysical level (such as biomarkers) could be assigned to EBT. An application that uses such tools but with emphasis on the organ or disease could be assigned to appropriate organ or disease IRG.

[BCMB Small Business SEPs]

The BCMB IRG reviews SBIR/STTR applications within the areas covered by its regular study sections in two small business panels.

Bioanalytical Chemistry, Chemistry and Biophysics SBIR/STTR 

[BACB SBIR/STTR: BCMB (10)]

The BACB SBIR/STTR Special Emphasis Panel reviews SBIR/STTR applications in the general area of bioanalytical chemistry, chemistry and biophysics.

Specific areas covered by the BACB SBIR/STTR SEP include:

• Bioanalytical techniques such as mass spectrometry, sensors, separations, spectroscopy, arrays, microfluidics, and novel assays
• Nanotechnology
• Novel materials, reagents, and surface chemistries related to either bioanalytical or biophysical methods
• Development of instrumentation and systems for proteomics and protein analysis
• Biophysical techniques such as magnetic resonance techniques; optical, electron and x-ray microscopy; x-ray and neutron diffraction techniques
• Agents for bioremediation
• Structural biology, especially protein structure and interactions

The BACB SBIR/STTR SEP has the following shared interests within the BCMB IRG:

• With the Drug Discovery and Development SBIR/STTR SEP [BCMB 11]:  The BACB SBIR/STTR SEP shares interest in protein chemistry with the DDD SBIR/STTR SEP.  If the emphasis is on the development of platforms, systems or methods for analysis, BACB SBIR/STTR may be more appropriate.  If the emphasis is toward development of a therapeutic compound, the DDD SBIR/STTR SEP may be more appropriate.

The BACB SBIR/STTR SEP has the following shared interests outside of the BCMB IRG:

• With the Bioengineering Sciences and Technologies [BST] IRG: The BACB SBIR/STTR SEP shares interests with the BST IRG in the development of new tools and instrumentation.  Small business applications in this area that focus on instrumentation and tools using bioanalytical, chemical or biophysical approaches may be assigned to the BACB SBIR/STTR SEP. Applications in this area that focus on instrumentation and tools using bioengineering and biomaterials approaches could be assigned to the BST IRG.
  
  
• With the Biology of Development and Aging [BDA]; Immunology [IMM]; Infectious Diseases and Microbiology [IDM]; AIDS and Related Research [AARR]; Oncological Sciences [ONC]; Hematology [HEME]; Cardiovascular Sciences [CVS]; Endocrinology, Metabolism, Nutrition, and Reproductive Sciences [EMNR]; Musculoskeletal, Oral and Skin Sciences [MOSS], Digestive Sciences [DIG], Respiratory Sciences [RES], Renal and Urological Sciences [RUS], and the Molecular, Cellular, and Developmental Neuroscience [MDCN] IRGs: The BACB SBIR/STTR SEP shares interests with disease and organ based IRGs in the development of use of new tools and instrumentation. Small business applications that focus on instrumentation and tools using bioanalytical, chemical or biophysical approaches may be assigned to the BACB SBIR/STTR SEP. Applications that focus on applying these tools to a disease or organ specific issue may be assigned to the relevant organ or disease IRG.

Drug Discovery and Development SBIR/STTR 

[DDD SBIR/STTR: BCMB (11)]

This Special Emphasis Panel reviews SBIR/STTR applications in small molecule drug discovery and development, medicinal chemistry, pharmaceutical chemistry, protein based therapeutics, and protein chemistry.  The focus is on development of therapeutics.

Specific areas covered by the DDD SBIR/STTR SEP include:

• Medicinal chemistry
• Synthetic chemistry
• Combinatorial chemistry
• Natural Product chemistry
• Pharmaceutical chemistry
• Computational drug design
• Protein therapeutics
• Protein chemistry and engineering
• Purification and biochemical analysis of proteins

The DDD SBIR/STTR SEP has the following shared interests within the BCMB IRG:

With the Bioanalytical Chemistry, Chemistry and Biophysics SBIR/STTR SEP [BCMB 10]:  The DDD SBIR/STTR SEP shares interest in protein chemistry with the BACB SBIR/STTR SEP.  If the emphasis is on the development of platforms, systems or methods for analysis, the BACB SBIR/STTR SEP may be more appropriate.  If the emphasis is toward development of a therapeutic compound, the DDD SBIR/STTR SEP may be more appropriate.

The DDD SBIR/STTR SEP has the following shared interests outside of the BCMB IRG:

• With the Bioengineering Sciences and Technologies [BST] IRG: The DDD SBIR/STTR SEP shares interests with the BST IRG in drug development and delivery. Small business applications that focus on the synthesis or chemistry of drugs and delivery systems may be referred to the DDD SBIR/STTR SEP. Small business applications that focus on the bioengineering of drugs and delivery systems may be referred to the BST IRG.
  
   
• With the Biology of Development and Aging [BDA]; Immunology [IMM]; Infectious Diseases and Microbiology [IDM]; AIDS and Related Research [AARR]; Oncological Sciences [ONC]; Hematology [HEME]; Cardiovascular Sciences [CVS]; Endocrinology, Metabolism, Nutrition, and Reproductive Sciences [EMNR]; Musculoskeletal, Oral and Skin Sciences [MOSS], Digestive Sciences [DIG], Respiratory Sciences [RES], Renal and Urological Sciences [RUS], and the Molecular, Cellular, and Developmental Neuroscience [MDCN] IRGs: The DDD SBIR/STTR SEP shares interests with disease and organ based IRGs in drug development and delivery.  SBIR/STTR applications with a focus on basic questions of structure determination or early drug discovery (hit to lead and lead optimization) or containing a substantial synthetic component may be assigned to the DDD SBIR/STTR SEP.  Applications on the clinical evaluation of a drug candidate may be assigned to the relevant organ or disease IRG.