Also called: Also called: XXY male
Klinefelter's syndrome is a condition that occurs in men who have an extra X chromosome in most of their cells. The syndrome can affect different stages of physical, language and social development. The most common symptom is infertility. Because they often don't make as much of the male hormone testosterone as other boys, teenagers with Klinefelter's syndrome may have less facial and body hair and may be less muscular than other boys. They may have trouble using language to express themselves. They may be shy and have trouble fitting in.
It is important to start treatment as early as possible. With treatment, most boys grow up to have normal sex lives, successful careers and normal social relationships. Treatments include
- Educational services
- Physical, speech and occupational therapy
- Medical treatments including testosterone replacement
National Institute of Child Health and Human Development
- Genetics Home Reference: Klinefelter syndrome(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=klinefeltersyndrome
- Klinefelter Syndrome(National Institute of Child Health and Human Development) - http://www.nichd.nih.gov/health/topics/klinefelter_syndrome.cfm
- Learning about Klinefelter Syndrome(National Human Genome Research Institute) - http://www.genome.gov/19519068
- Testosterone Test(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/testosterone/test.html
- Understanding Klinefelter Syndrome: A Guide for XXY Males and Their Families(National Institute of Child Health and Human Development) - http://www.nichd.nih.gov/publications/pubs/klinefelter.cfm
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Low Testosterone(Patient Education Institute) - Requires Flash Player - http://www.nlm.nih.gov/medlineplus/tutorials/lowtestosterone/htm/index.htm
Also available in Spanish http://www.nlm.nih.gov/medlineplus/spanish/tutorials/lowtestosteronespanish/htm/index.htm
- Patient's Guide to Low Testosterone(Hormone Foundation, Endocrine Society) - http://www.medem.com/medlb/article_detaillb.cfm?article_ID=ZZZO7PDVDLC&sub_cat=57
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Low Testosterone(Patient Education Institute) - Requires Flash Player - http://www.nlm.nih.gov/medlineplus/tutorials/lowtestosterone/htm/index.htm
Also available in Spanish http://www.nlm.nih.gov/medlineplus/spanish/tutorials/lowtestosteronespanish/htm/index.htm
- ClinicalTrials.gov: Klinefelter Syndrome(National Institutes of Health) - http://clinicaltrials.gov/search/open/condition=%22Klinefelter+Syndrome%22
- Genetics Home Reference: Klinefelter syndrome(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=klinefeltersyndrome
- Klinefelters Current Studies and Clinical Trials(Klinefelter Syndrome and Associates) - http://www.genetic.org/knowledge/support/action/C130/
- Article: Intracranial germ cell tumors: association with Klinefelter syndrome and sex... - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18758161&tool=MedlinePlus
- Article: Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support... - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18668569&tool=MedlinePlus
- Article: Testicular function in Klinefelter syndrome. - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18504390&tool=MedlinePlus
- Klinefelter's Syndrome -- see more articles - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=klinefelter+syndrome[majr]+AND+humans[mh]+AND+english[la]+NOT+(letter[pt]+OR+editorial[pt])&doptcmdl=summary&cmd_current=Limits&pmfilter_EDatLimit=last+1+Year&tool=MedlinePlus
- US Clinic Directory Search(University of Washington) - http://www.genetests.org/servlet/access?id=8888891&key=yLoqrsrCVms-M&fcn=y&fw=ZDht&filename=/clinicsearch/searchclinic.html
- Klinefelter Syndrome and Associates - http://www.genetic.org/
- National Institute of Child Health and Human Development - http://www.nichd.nih.gov/
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Delayed Puberty(Nemours Foundation) - http://kidshealth.org/teen/sexual_health/changing_body/delayed_puberty.html
Also available in Spanish http://kidshealth.org/teen/en_espanol/sexual/delayed_puberty_esp.html
- Genetics/Birth Defects - http://www.nlm.nih.gov/medlineplus/geneticsbirthdefects.html
- Men - http://www.nlm.nih.gov/medlineplus/men.html
The primary NIH organization for research on Klinefelter's Syndrome is the National Institute of Child Health and Human Development - http://www.nichd.nih.gov/