-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 PlHYDLmeS/9Bh9WPLmF3LWgMxbCeK3K/wY+kbUEGaMxMih6iNkLP9xKpJAH4e911
 JRxh8vd3Xd/ydibrXxWUDQ==

<SEC-DOCUMENT>0001181431-07-076711.txt : 20071220
<SEC-HEADER>0001181431-07-076711.hdr.sgml : 20071220
<ACCEPTANCE-DATETIME>20071220095637
ACCESSION NUMBER:		0001181431-07-076711
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20071219
FILED AS OF DATE:		20071220
DATE AS OF CHANGE:		20071220

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			International Securities Exchange Holdings, Inc.
		CENTRAL INDEX KEY:			0001295230
		STANDARD INDUSTRIAL CLASSIFICATION:	SECURITY & COMMODITY BROKERS, DEALERS, EXCHANGES & SERVICES [6200]
		IRS NUMBER:				205219710
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		60 BROAD STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10004
		BUSINESS PHONE:		212-943-2400

	MAIL ADDRESS:	
		STREET 1:		60 BROAD STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10004

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	International Securities Exchange, Inc.
		DATE OF NAME CHANGE:	20040623

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Brenner Andrew
		CENTRAL INDEX KEY:			0001365373

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32435
		FILM NUMBER:		071317969

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		212-943-2400

	MAIL ADDRESS:	
		STREET 1:		INTERNATIONAL SECURITIES EXCHANGE
		STREET 2:		60 BROAD STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10004
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd180923.xml
<DESCRIPTION>FORM 4 - ANDREW BRENNER
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-12-19</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001295230</issuerCik>
        <issuerName>International Securities Exchange Holdings, Inc.</issuerName>
        <issuerTradingSymbol>ISE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001365373</rptOwnerCik>
            <rptOwnerName>Brenner Andrew</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>INTERNATIONAL SECURITIES EXCHANGE</rptOwnerStreet1>
            <rptOwnerStreet2>60 BROAD STREET</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10004</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Managing Director</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-12-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3515</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>67.50</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>40.86</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2007-12-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>18000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>26.64</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2016-05-31</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Class A Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>18000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">All of ISE's outstanding common stock was canceled pursuant to the Agreement and Plan of Merger, dated as of April 30, 2007 among ISE, Eurex Frankfurt AG, and Ivan Acquisition Co. (&quot;Merger Agreement&quot;) in exchange for a cash payment of $67.50 on the effective date of the merger.</footnote>
        <footnote id="F2">All of ISE's outstanding stock options were canceled pursuant to the Merger Agreement in exchange for a cash payment of $67.50 minus the exercise price of the option on the effective date of the merger.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Michael J. Simon as Attorney-in-Fact for Andrew Brenner</signatureName>
        <signatureDate>2007-12-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----