Also called: Also called: Clotting disorders, Hypercoagulability
Normally, if you get hurt, your body forms a blood clot to stop the bleeding. For blood to clot, your body needs cells called platelets and proteins known as clotting factors. If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should.
Bleeding disorders can be the result of other diseases, such as severe liver disease. They can also be inherited. The most common inherited bleeding disorders are von Willebrand Disease (VWD) and hemophilia. Bleeding disorders can also be a side effect of medicines.
- Bleeding Disorders(National Women's Health Information Center) - http://womenshealth.gov/faq/bleed.htm
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Excessive Blood Clotting
(National Heart, Lung, and Blood Institute) - http://www.nhlbi.nih.gov/health/dci/Diseases/ebc/ebc_what.html
- Bleeding and Clotting Disorders(Merck & Co., Inc.) - http://www.merck.com/mmhe/sec14/ch173/ch173a.html
- Bleeding Disorders(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/conditions/bleeding_disorders.html
- Hypercoagulable Disorders(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/conditions/hypercoagulable_disorders.html
- Some Arteries Opened Safely Without Heparin(10/09/2008, HealthDay) - http://www.nlm.nih.gov/medlineplus/news/fullstory_70272.html
- FDA Approves First Bone Marrow Stimulator to Treat Immune-Related Low Platelet Counts(08/22/2008, Food and Drug Administration) - http://www.fda.gov/bbs/topics/NEWS/2008/NEW01876.html
- aPTT(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/aptt/test.html
- Coagulation Factors(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/coagulation_factors/test.html
- D-dimer(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/d_dimer/test.html
- Easy Bleeding(DSHI Systems) - Requires Flash Player - http://www.freemd.com/easy-bleeding/visit-virtual-doctor.htm
- Factor V Leiden and PT 20210(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/factor_v_and_pt20210/test.html
- Fibrinogen(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/fibrinogen/test.html
- International Normalized Ratio (INR)(Heart Rhythm Society) - Links to PDF - http://www.heartrhythmfoundation.org/a-fib/INR_FINAL.pdf
- Platelet Count(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/platelet/test.html
- PT and INR (Prothrombin Time, International Normalized Ratio)(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/pt/test.html
- FDA Approves New Product to Treat Von Willebrand Disease(Food and Drug Administration) - http://www.fda.gov/bbs/topics/NEWS/2007/NEW01553.html
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JAMA Patient Page: Blood Transfusion(American Medical Association) - http://jama.ama-assn.org/cgi/reprint/292/13/1646.pdf
Also available in Spanish http://jama.ama-assn.org/cgi/data/292/13/1646/DC1/1
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Antiphospholipid Antibody Syndrome(National Heart, Lung, and Blood Institute) - http://www.nhlbi.nih.gov/health/dci/Diseases/aps/aps_what.html
- Bleeding into the Skin (Petechiae)(Mayo Foundation for Medical Education and Research) - http://www.mayoclinic.com/print/petechiae/HQ01208/METHOD=print
- Disseminated Intravascular Coagulation(Merck & Co., Inc.) - http://www.merck.com/mmhe/sec14/ch173/ch173h.html
- Factor V Leiden(American Heart Association) - Links to PDF - http://circ.ahajournals.org/cgi/reprint/107/15/e94.pdf
- Heparin-Induced Thrombocytopenia(American Heart Association) - http://circ.ahajournals.org/cgi/content/full/114/8/e355
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Hypercoagulation: Excessive Blood Clotting(American Academy of Family Physicians) - http://familydoctor.org/online/famdocen/home/common/blood/244.printerview.html
Also available in Spanish http://familydoctor.org/online/famdoces/home/common/blood/244.printerview.html
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Idiopathic Thrombocytopenic Purpura(National Heart, Lung, and Blood Institute) - http://www.nhlbi.nih.gov/health/dci/Diseases/Itp/ITP_WhatIs.html
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Thrombocytopenia(National Heart, Lung, and Blood Institute) - http://www.nhlbi.nih.gov/health/dci/Diseases/thcp/thcp_what.html
- Thrombocytopenia (Low Platelet Count)(Mayo Foundation for Medical Education and Research) - http://www.mayoclinic.com/print/thrombocytopenia/DS00691/DSECTION=all&METHOD=print
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von Willebrand Disease(National Heart, Lung, and Blood Institute) - http://www.nhlbi.nih.gov/health/dci/Diseases/vWD/vWD_WhatIs.html
- What Are Clotting Disorders?(National Hemophilia Foundation) - http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=176&contentid=378
- What Is TTP?(University of Oklahoma Health Sciences Center) - http://w3.ouhsc.edu/platelets/TTP/what%20is%20ttp.html
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Important Information to Know When You Are Taking: Coumadin and Vitamin K(National Institutes of Health, Clinical Center) - Links to PDF - http://dietary-supplements.info.nih.gov/factsheets/cc/coumadin1.pdf
- Platelets and Cardiovascular Disease(American Heart Association) - Links to PDF - http://circ.ahajournals.org/cgi/reprint/108/13/e88.pdf
- Updated Labeling for Coumadin (Warfarin)(Food and Drug Administration) - http://www.fda.gov/consumer/updates/warfarin081707.html
- Bleeding Disorders: Financial and Insurance Issues(National Hemophilia Foundation) - http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=34&contentid=24
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ClinicalTrials.gov: Blood Coagulation Disorders(National Institutes of Health) - http://clinicaltrials.gov/search/open/condition=%22Blood+Coagulation+Disorders%22
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ClinicalTrials.gov: Thrombocytopenia(National Institutes of Health) - http://clinicaltrials.gov/search/open/condition=%22Thrombocytopenia%22
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ClinicalTrials.gov: von Willebrand Disease(National Institutes of Health) - http://clinicaltrials.gov/search/open/condition=%22von+Willebrand+Disease%22
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Genetics Home Reference: Factor V Leiden thrombophilia(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=factorvleidenthrombophilia
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Genetics Home Reference: Prothrombin deficiency(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=prothrombindeficiency
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Genetics Home Reference: Prothrombin thrombophilia(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=prothrombinthrombophilia
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Genetics Home Reference: Von Willebrand disease(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=vonwillebranddisease
References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Trauma and coagulopathy: a new paradigm to consider. - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18711042&tool=MedlinePlus
- Article: The significance of bone marrow biopsy and JAK2V617F mutation in... - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18701405&tool=MedlinePlus
- Article: Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red... - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18695460&tool=MedlinePlus
- Bleeding Disorders -- see more articles - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=blood+platelet+disorders[majr]+OR+blood+coagulation+disorders[majr]+NOT+(thrombocytopenia[mh]+OR+von+willebrand+disease[mh])+AND+humans[mh]+AND+english[la]+AND+(review[pt]+OR+guideline[pt]+OR+clinical+trial[pt]+OR+patient+education+handout[pt]+OR+jsubsetk[text]+OR+jsubsetaim[text]+OR+jsubsetn[text]+NOT+(letter[pt]+OR+editorial[pt]+OR+case+reports[pt]))&doptcmdl=summary&cmd_current=Limits&pmfilter_EDatLimit=last+1+Year&tool=MedlinePlus
- Thrombocytopenias -- see more articles - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=thrombocytopenia[majr]+AND+english[la]+AND+humans[mh]+AND+(review[pt]+OR+guideline[pt]+OR+clinical+trial[pt]+OR+jsubsetk[text]+OR+jsubsetaim[text]+OR+jsubsetn[text]+OR+patient+education+handout[pt])+NOT+(letter[pt]+OR+editorial[pt]+OR+case+reports[pt])&doptcmdl=summary&cmd_current=Limits&pmfilter_EDatLimit=last+1+Year&tool=MedlinePlus
- von Willebrand disease -- see more articles - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=(von+willebrand+disease[majr]+OR+von+willebrand+factor[majr])+AND+humans[mh]+AND+english[la]+NOT+(letter[pt]+OR+editorial[pt])&doptcmdl=summary&cmd_current=Limits&pmfilter_EDatLimit=last+1+Year&tool=MedlinePlus
- bleeding disorder - http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&binning-state=group%3d%3dMedical%20Encyclopedia&query=bleeding+disorder
- Bleeding and Clotting Disorders Glossary(National Hemophilia Foundation) - http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=39&contentid=28
- Blood Bank Locator(American Association of Blood Banks) - http://www.aabb.org/Content/Donate_Blood/Where_to_Donate/BloodBankLocatorMap?transaction=search&template=map_search
- Find a Hematologist(American Society of Hematology) - https://store.hematology.org/fah/fahhome.htm
- Find a Pediatric Hematologist/Oncologist(American Society of Pediatric Hematology/Oncology) - http://www.association-office.com/aspho/etools/publicdir/search.cfm
- Hemostasis and Thrombosis Centers(Centers for Disease Control and Prevention) - http://www.cdc.gov/ncbddd/hbd/thromb_center_list.htm
- CDC Division of Blood Disorders(Centers for Disease Control and Prevention) - http://www.cdc.gov/ncbddd/hbd/
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National Heart, Lung, and Blood Institute - http://www.nhlbi.nih.gov/
- National Hemophilia Foundation - http://www.hemophilia.org/
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Blood(Nemours Foundation) - http://kidshealth.org/parent/general/body_basics/blood.html
Also available in Spanish http://kidshealth.org/parent/en_espanol/general/blood_esp.html
- Hemophilia(Nemours Foundation) - http://kidshealth.org/parent/medical/genetic/hemophilia.html
- Von Willebrand Disease(Nemours Foundation) - http://kidshealth.org/parent/medical/heart/vwd.html
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Blood Transfusions(Nemours Foundation) - http://kidshealth.org/teen/your_body/medical_care/transfusions.html
Also available in Spanish http://kidshealth.org/teen/en_espanol/cuerpo/transfusions_esp.html
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Von Willebrand Disease(Nemours Foundation) - http://kidshealth.org/teen/diseases_conditions/blood/vwd.html
Also available in Spanish http://kidshealth.org/teen/en_espanol/enfermedades/vwd_esp.html
- Bleeding and Clotting Disorders in Women(Centers for Disease Control and Prevention) - http://www.cdc.gov/ncbddd/hbd/women.htm
- Bleeding Disorders(National Women's Health Information Center) - http://womenshealth.gov/faq/bleed.htm
- Hemophilia - http://www.nlm.nih.gov/medlineplus/hemophilia.html
- Blood, Heart and Circulation - http://www.nlm.nih.gov/medlineplus/bloodheartandcirculation.html
The primary NIH organization for research on Bleeding Disorders is the National Heart, Lung, and Blood Institute - http://www.nhlbi.nih.gov/