1997 DOE Human Genome Program Contractor-Grantee Workshop VI

Sequencing Technologies Table of Contents of abstracts from the DOE Human Genome Program Contractor-Grantee Workshop VI November 9-13, 1997, Santa Fe, NM
Home Author Index Sequencing Table of Contents Abstracts Sequencing Technologies Table of Contents Abstracts Mapping and Resources Table of Contents Abstracts Informatics Table of Contents Abstracts Ethical, Legal, and Social Issues Table of Contents Abstracts Infrastructure Table of Contents Abstracts Ordering Information	Rhodobacter capsulatus Genome Sequencing Project: DENS Technology Testing Ground Mugasimangalam Raja, Vincent Molloy, Lev Lvovsky, James Akowski, Jonathan Schisler, Yakov Kogan#, Michael Fonstein#, Robert Haselkorn# and Levy Ulanovsky Argonne National Laboratory, Argonne, IL #University of Chicago, Chicago, IL Cosmid Sized Templates for DENS Sequencing Technique Mugasimangalam Raja, Vincent Molloy, Lev Lvovsky# and Levy Ulanovsky# CMB, Argonne National Laboratory, Argonne, IL #Weizmann Institute of Science, Rehovot, Israel Sequencing of Human Telomeric Region DNA by Differential Extension with Nucleotide Subsets (DENS) Dina Zevin-Sonkin#, Anahit Ghochikyan#, Arthur Liberzon#, Lev Lvovsky# and Levy Ulanovsky# # Dept. of Structural Biology, Weizmann Institute of Science, Rehovot, ISRAEL CMB, Argonne National Laboratory, Argonne, IL Primer Walking Through Alu Repeats Using DENS Sequencing Technique Dina Zevin-Sonkin#, Anahit Ghochikyan#, Arthur Liberzon#, Lev Lvovsky#, and Levy Ulanovsky# #Weizmann Institute of Science, Rehovot, Israel CMB, Argonne National Laboratory, Argonne, IL Structural Insights into the Properties of DNA Polymerases Important for DNA Sequencing Stanley Tabor, Sylvie Doublié, Tom Ellenberger and Charles Richardson Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 Semiautomated Mutagenesis and Screening of T7 RNA Polymerases Mark W. Knuth, Scott A. Lesley, and Heath E. Klock Promega Corporation 2800 Woods Hollow Road, Madison, WI 53597 Vectors and Biochemistry for Sequencing by Nested Deletions John J. Dunn and Matthew Randesi Biology Department, Brookhaven National Laboratory, Upton, New York 11973 Trapping of DNA in Non-Uniform Oscillating Electric Fields Charles L. Asbury, Ger van den Engh Department of Molecular Biotechnology, University of Washington, Seattle, WA 98105 Energy Transfer Fluorescent Primers Optimized for DNA Sequencing and Diagnostics Su-Chun Hung, Yiwen Wang, Richard A. Mathies* and Alexander N. Glazer Departments of Molecular and Cell Biology* and Chemistry, University of California, Berkeley, CA 94720 Direct PCR Sequencing with Boronated Nucleotides Kenneth W. Porter, Dima Sergueev, Ahmad Hasan, J. David Briley and Barbara Ramsay Shaw Department of Chemistry, Duke University, Durham, NC 27708 Advances in DNA Analysis Using Capillary Array Electrophoresis Indu Kheterpal, James R. Scherer, William W. Ja, Yiwen Wang and Richard A. Mathies Department of Chemistry, University of California, Berkeley, CA 94720 Development of a Low Cost, High Throughput, Four Color DNA Sequencer Michael S. Westphall, David R. Rank and Lloyd M. Smith University of Wisconsin-Madison, Department of Chemistry, 1101 University Ave., Madison, WI 53706 Multiplexed Integrated On-line System for DNA Sequencing by Capillary Electrophoresis: From Template to Called Bases Edward S. Yeung* and Hongdong Tan Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, Ames, IA 50011 Production Sequencing Evaluation of a Nearly Automated 96-Capillary Array DNA Sequencer Developed at LBNL Jian Jin, William F. Kolbe, Yunian Lou and Earl W. Cornell Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Engineering Science Department, Human Genome Group, 1 Cyclotron Road, Berkeley, CA 94720 DNA Sequencing by Capillary Electrophoresis from Sample Preparation to Resulting Sequence: A Robust High Throughput Procedure with Long Read Length Salas-Solano, O., Carrilho, E., Ruiz-Martinez^1, M.C., Goetzinger², W., Kotler, L., Sosic, Z., and Karger, B.L. Barnett Institute and Department of Chemistry, Northeastern University, Boston, MA, 02115 A Fully Automated 96-Capillary DNA Sequencer Qingbo Li, Thomas E. Kane, Changsheng Liu, John Kernan, and James R. Hoyland Premier American Technologies Corp. Development of a Microchannel Based DNA Sequencer Courtney Davidson, Joseph Balch, Larry Brewer, Joe Kimbrough, Steve Swierkowski, David Nelson, Ramkrishna Madabhushi, Ron Pastrone, Ann Lee, Paula McCready, Aaron Adamson, Bob Bruce, Ray Mariella, and Anthony Carrano Lawrence Livermore National Laboratory, Human Genome Center Microchannel Process Development and Fabrication for DNA Sequencing Steve Swierkowski, Joseph Balch, Courtney Davidson, and Lisa Tarte Lawrence Livermore National Laboratory, Human Genome Center An Optical Trigger for Locating Microchannel Position Laurence R. Brewer, Joseph Kimbrough, Courtney Davidson, and Joseph Balch Lawrence Livermore National Laboratory, Human Genome Center Multiple Capillary DNA Sequencer Illuminated by a Waveguide Mark A. Quesada, Harbans S. Dhadwal, David J. Fisk, Janine S. Graves and F. William Studier Biology Department, Brookhaven National Laboratory, Upton, New York 11973 Technology Development and Informatics Tools for Genome Sequencing E.R. Mardis, L. Hillier, A. Chinwalla, M. Cook, M. Holman, G. Marth, R. McGrane, D.A. Panussis, D.C. Peluso, L.L. Rifkin, J.E. Snider, J. Strong, E. Stuebe, R.H. Waterston, M. Wendl, R.K. Wilson Washington University School of Medicine, Genome Sequencing Center, St. Louis, MO 63108 Single Molecule DNA Sequencing Hong Cai, Peter M. Goodwin, James H. Jett, Richard A. Keller, Nicholas P. Machara, Susan L. Riley, and David J. Semin Los Alamos National Laboratory, Los Alamos, New Mexico 87545 On the Road to Rapid Exonuclease Screening for DNA Sequencing** Hong Cai, # Susan L. Riley, # Kristina Kommander, * John Nolan, * Richard A. Keller# Los Alamos National Laboratory, Chemical Science and Technology# and Life Sciences* Sizing of Individual DNA Fragments Zhengping Huang, Yongseong Kim, Jonathan L. Longmire, Nancy C. Brown, James H. Jett and Richard A. Keller Los Alamos National Laboratory, Los Alamos, New Mexico 87545 Single Molecule DNA Detection in Microfabricated Capillary Electrophoresis Chips Brian B. Haab and Richard A. Mathies Department of Chemistry, University of California, Berkeley, CA 94720 Sizing Megadalton DNA by Mass Spectrometry W. Henry Benner LBNL, 1 Cyclotron Road, Berkeley, CA 94720 Evaluation of New Membrane Surfaces for Chemiluminescent Assays Christopher S. Martin, Jing Ying Lee, Betty Liu, Jeffrey Shumway, John C. Voyta and Irena Bronstein Tropix, Inc., 47 Wiggins Ave., Bedford, MA 01730 Advances in Microfabricated Integrated DNA Analysis Systems Adam T. Woolley, Peter C. Simpson, Shaorong Liu, Kaiqin Lao, Stephen J. Williams, Mary X. Tang, Lester Hutt, Alexander N. Glazer and Richard A. Mathies Department of Chemistry and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 The Flowthrough Genosensor Program at Oak Ridge National Laboratory Kenneth Beattie, Mitchel Doktycz, Ming Zhan, Gabriel Betanzos, William Bryan, John Turner Oak Ridge National Laboratory, Oak Ridge, TN 37831-6123 Technical Aspects of Fabrication and Quantitative Analysis of DNA Micro-Arrays for Comparative Genomic Hybridization Damir Sudar, Steve Clark, Ian Poole, Rick Segraves, Stephen Lockett, Arthur Jones, Donna Albertson, Joe Gray, Daniel Pinkel Lawrence Berkeley National Laboratory Multilabel SERS Gene Probes for DNA Sequencing T. Vo-Dinh^, D.L. Stokes¹, G.D. Griffin¹, N. Isola¹, J.P. Alarie¹, U.J. Kim², M.I. Simon¹, T. Bunde¹ ^ Corresponding Author; Oak Ridge National Laboratory, Oak Ridge, TN 37831-6101 ¹ Advanced Monitoring Development Group, Life Sciences Div., Oak Ridge National Laboratory, Oak Ridge, TN 37831-6101 ² Div. of Biology, Calif. Inst. of Technology, Pasadena, CA 91125 MicroArray of Gel Immobilized Compounds A. Mirzabekov Joint Human Genome Program: Argonne National Laboratory, U.S.A., and Engelhardt Institute of Molecular Biology, Moscow Flow Cytometry-Based Polymorphism Detection and Analysis John P. Nolan, Hong Cai, Kristina Kommander, and P. Scott White Los Alamos National Laboratory, Life Sciences Division, Los Alamos, New Mexico 87545 DNA Characterization by Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry David S. Wunschel, Ljiljana Pasa Tolic, David. C. Muddiman, James E. Bruce, Steve A. Hofstadler and Richard D. Smith Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352 Improved Mass Spectrometric Resolution for PCR Product Size Measurement Gregory B. Hurst, Kristal Weaver, and Michelle V. Buchanan Chemical and Analytical Sciences Division, Oak Ridge National Laboratory, Oak Ridge TN 37831-6365 Laser Desorption Mass Spectrometry for Quick DNA Sequencing and Analysis C. H. Winston Chen, N. I. Taranenko, Y. F. Zhu, S. L. Allman, V. V. Golovlev and N. R. Isola Life Science Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6378 Genome Analysis Technologies George Church, Martha Bulyk, Sonali Bose, Chris Harbison, Linxiao Xu, Poguang Wang, Laura Kutney, T. O'Keeffe, Dereth Phillips Department of Genetics, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115 2'-Fluoro Modified Nucleic Acids: Polymerase-Directed Synthesis, Properties, and Stability to Analysis by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Tetsuyoshi Ono, Mark Scalf, Lloyd M. Smith University of Wisconsin-Madison Chemistry Dept. Progress with Concatenation cDNA Sequencing Wei Yu and Richard A. Gibbs Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 Development of a DNA Array System with Focus on Transcription Pathway Prediction Trey Ideker, Richard Karp, and Leroy Hood University of Washington, Department of Molecular Biotechnology, Health Sciences Building Box 357730, Seattle, WA, 98195 DNA Sample Manipulation and Automation Trevor L. Hawkins¹, Laurent Jacotat² , Mary Pat Reeve¹ and Kevin McKernan² 1 Integrated Genomics Technologies. 800 Research Parkway, Meriden, CT Improved Analysis of Comparative Genomic Hybridization Data by Bivariate Image Analysis Stefan Burde and Babetta L. Marrone Los Alamos National Laboratory, Los Alamos, NM 87545

Sequencing Technologies
Table of Contents

of abstracts from the
DOE Human Genome Program Contractor-Grantee Workshop VI
November 9-13, 1997, Santa Fe, NM

Home
Author Index
Sequencing: Table of Contents; Abstracts
Sequencing Technologies: Table of Contents; Abstracts
Mapping and Resources: Table of Contents; Abstracts
Informatics: Table of Contents; Abstracts
Ethical, Legal, and Social Issues: Table of Contents; Abstracts
Infrastructure: Table of Contents; Abstracts
Ordering Information

Rhodobacter capsulatus Genome Sequencing Project: DENS Technology Testing Ground
Mugasimangalam Raja, Vincent Molloy, Lev Lvovsky, James Akowski, Jonathan Schisler, Yakov Kogan#, Michael Fonstein#, Robert Haselkorn# and Levy Ulanovsky
Argonne National Laboratory, Argonne, IL
#University of Chicago, Chicago, IL
Cosmid Sized Templates for DENS Sequencing Technique
Mugasimangalam Raja*, Vincent Molloy*, Lev Lvovsky# and Levy Ulanovsky*#
*CMB, Argonne National Laboratory, Argonne, IL
#Weizmann Institute of Science, Rehovot, Israel
Sequencing of Human Telomeric Region DNA by Differential Extension with Nucleotide Subsets (DENS)
Dina Zevin-Sonkin#, Anahit Ghochikyan#, Arthur Liberzon#, Lev Lvovsky# and Levy Ulanovsky*#
# Dept. of Structural Biology, Weizmann Institute of Science, Rehovot, ISRAEL
* CMB, Argonne National Laboratory, Argonne, IL
Primer Walking Through Alu Repeats Using DENS Sequencing Technique
Dina Zevin-Sonkin#, Anahit Ghochikyan#, Arthur Liberzon#, Lev Lvovsky#, and Levy Ulanovsky*#
#Weizmann Institute of Science, Rehovot, Israel
*CMB, Argonne National Laboratory, Argonne, IL
Structural Insights into the Properties of DNA Polymerases Important for DNA Sequencing
Stanley Tabor, Sylvie Doublié, Tom Ellenberger and Charles Richardson
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
Semiautomated Mutagenesis and Screening of T7 RNA Polymerases
Mark W. Knuth, Scott A. Lesley, and Heath E. Klock
Promega Corporation 2800 Woods Hollow Road, Madison, WI 53597
Vectors and Biochemistry for Sequencing by Nested Deletions
John J. Dunn and Matthew Randesi
Biology Department, Brookhaven National Laboratory, Upton, New York 11973
Trapping of DNA in Non-Uniform Oscillating Electric Fields
Charles L. Asbury, Ger van den Engh
Department of Molecular Biotechnology, University of Washington, Seattle, WA 98105
Energy Transfer Fluorescent Primers Optimized for DNA Sequencing and Diagnostics
Su-Chun Hung*, Yiwen Wang**, Richard A. Mathies** and Alexander N. Glazer
Departments of Molecular and Cell Biology* and Chemistry**, University of California, Berkeley, CA 94720
Direct PCR Sequencing with Boronated Nucleotides
Kenneth W. Porter, Dima Sergueev, Ahmad Hasan, J. David Briley and Barbara Ramsay Shaw
Department of Chemistry, Duke University, Durham, NC 27708
Advances in DNA Analysis Using Capillary Array Electrophoresis
Indu Kheterpal, James R. Scherer, William W. Ja, Yiwen Wang and Richard A. Mathies
Department of Chemistry, University of California, Berkeley, CA 94720
Development of a Low Cost, High Throughput, Four Color DNA Sequencer
Michael S. Westphall, David R. Rank and Lloyd M. Smith
University of Wisconsin-Madison, Department of Chemistry, 1101 University Ave., Madison, WI 53706
Multiplexed Integrated On-line System for DNA Sequencing by Capillary Electrophoresis: From Template to Called Bases
Edward S. Yeung* and Hongdong Tan
Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, Ames, IA 50011
Production Sequencing Evaluation of a Nearly Automated 96-Capillary Array DNA Sequencer Developed at LBNL
Jian Jin, William F. Kolbe, Yunian Lou and Earl W. Cornell
Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Engineering Science Department, Human Genome Group, 1 Cyclotron Road, Berkeley, CA 94720
DNA Sequencing by Capillary Electrophoresis from Sample Preparation to Resulting Sequence: A Robust High Throughput Procedure with Long Read Length
Salas-Solano, O., Carrilho, E., Ruiz-Martinez^1, M.C., Goetzinger², W., Kotler, L., Sosic, Z., and Karger, B.L.
Barnett Institute and Department of Chemistry, Northeastern University, Boston, MA, 02115
A Fully Automated 96-Capillary DNA Sequencer
Qingbo Li, Thomas E. Kane, Changsheng Liu, John Kernan, and James R. Hoyland
Premier American Technologies Corp.
Development of a Microchannel Based DNA Sequencer
Courtney Davidson, Joseph Balch, Larry Brewer, Joe Kimbrough, Steve Swierkowski, David Nelson, Ramkrishna Madabhushi, Ron Pastrone, Ann Lee, Paula McCready, Aaron Adamson, Bob Bruce, Ray Mariella, and Anthony Carrano
Lawrence Livermore National Laboratory, Human Genome Center
Microchannel Process Development and Fabrication for DNA Sequencing
Steve Swierkowski, Joseph Balch, Courtney Davidson, and Lisa Tarte
Lawrence Livermore National Laboratory, Human Genome Center
An Optical Trigger for Locating Microchannel Position
Laurence R. Brewer, Joseph Kimbrough, Courtney Davidson, and Joseph Balch
Lawrence Livermore National Laboratory, Human Genome Center
Multiple Capillary DNA Sequencer Illuminated by a Waveguide
Mark A. Quesada, Harbans S. Dhadwal, David J. Fisk, Janine S. Graves and F. William Studier
Biology Department, Brookhaven National Laboratory, Upton, New York 11973
Technology Development and Informatics Tools for Genome Sequencing
E.R. Mardis, L. Hillier, A. Chinwalla, M. Cook, M. Holman, G. Marth, R. McGrane, D.A. Panussis, D.C. Peluso, L.L. Rifkin, J.E. Snider, J. Strong, E. Stuebe, R.H. Waterston, M. Wendl, R.K. Wilson
Washington University School of Medicine, Genome Sequencing Center, St. Louis, MO 63108
Single Molecule DNA Sequencing
Hong Cai, Peter M. Goodwin, James H. Jett, Richard A. Keller, Nicholas P. Machara, Susan L. Riley, and David J. Semin
Los Alamos National Laboratory, Los Alamos, New Mexico 87545
On the Road to Rapid Exonuclease Screening for DNA Sequencing
Hong Cai, # Susan L. Riley, # Kristina Kommander, * John Nolan, * Richard A. Keller#
Los Alamos National Laboratory, Chemical Science and Technology# and Life Sciences*
Sizing of Individual DNA Fragments
Zhengping Huang, Yongseong Kim, Jonathan L. Longmire, Nancy C. Brown, James H. Jett and Richard A. Keller
Los Alamos National Laboratory, Los Alamos, New Mexico 87545
Single Molecule DNA Detection in Microfabricated Capillary Electrophoresis Chips
Brian B. Haab and Richard A. Mathies
Department of Chemistry, University of California, Berkeley, CA 94720
Sizing Megadalton DNA by Mass Spectrometry
W. Henry Benner
LBNL, 1 Cyclotron Road, Berkeley, CA 94720
Evaluation of New Membrane Surfaces for Chemiluminescent Assays
Christopher S. Martin, Jing Ying Lee, Betty Liu, Jeffrey Shumway, John C. Voyta and Irena Bronstein
Tropix, Inc., 47 Wiggins Ave., Bedford, MA 01730
Advances in Microfabricated Integrated DNA Analysis Systems
Adam T. Woolley, Peter C. Simpson, Shaorong Liu, Kaiqin Lao, Stephen J. Williams, Mary X. Tang, Lester Hutt, Alexander N. Glazer and Richard A. Mathies
Department of Chemistry and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720
The Flowthrough Genosensor Program at Oak Ridge National Laboratory
Kenneth Beattie, Mitchel Doktycz, Ming Zhan, Gabriel Betanzos, William Bryan, John Turner
Oak Ridge National Laboratory, Oak Ridge, TN 37831-6123
Technical Aspects of Fabrication and Quantitative Analysis of DNA Micro-Arrays for Comparative Genomic Hybridization
Damir Sudar, Steve Clark, Ian Poole, Rick Segraves, Stephen Lockett, Arthur Jones, Donna Albertson, Joe Gray, Daniel Pinkel
Lawrence Berkeley National Laboratory
Multilabel SERS Gene Probes for DNA Sequencing
T. Vo-Dinh^*, D.L. Stokes¹, G.D. Griffin¹, N. Isola¹, J.P. Alarie¹, U.J. Kim², M.I. Simon¹, T. Bunde¹
^* Corresponding Author; Oak Ridge National Laboratory, Oak Ridge, TN 37831-6101
¹ Advanced Monitoring Development Group, Life Sciences Div., Oak Ridge National Laboratory, Oak Ridge, TN 37831-6101
² Div. of Biology, Calif. Inst. of Technology, Pasadena, CA 91125
MicroArray of Gel Immobilized Compounds
A. Mirzabekov
Joint Human Genome Program: Argonne National Laboratory, U.S.A., and Engelhardt Institute of Molecular Biology, Moscow
Flow Cytometry-Based Polymorphism Detection and Analysis
John P. Nolan, Hong Cai, Kristina Kommander, and P. Scott White
Los Alamos National Laboratory, Life Sciences Division, Los Alamos, New Mexico 87545
DNA Characterization by Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
David S. Wunschel, Ljiljana Pasa Tolic, David. C. Muddiman, James E. Bruce, Steve A. Hofstadler and Richard D. Smith
Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352
Improved Mass Spectrometric Resolution for PCR Product Size Measurement
Gregory B. Hurst, Kristal Weaver, and Michelle V. Buchanan
Chemical and Analytical Sciences Division, Oak Ridge National Laboratory, Oak Ridge TN 37831-6365
Laser Desorption Mass Spectrometry for Quick DNA Sequencing and Analysis
C. H. Winston Chen, N. I. Taranenko, Y. F. Zhu, S. L. Allman, V. V. Golovlev and N. R. Isola
Life Science Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6378
Genome Analysis Technologies
George Church, Martha Bulyk, Sonali Bose, Chris Harbison, Linxiao Xu, Poguang Wang, Laura Kutney, T. O'Keeffe, Dereth Phillips
Department of Genetics, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115
2'-Fluoro Modified Nucleic Acids: Polymerase-Directed Synthesis, Properties, and Stability to Analysis by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
Tetsuyoshi Ono, Mark Scalf, Lloyd M. Smith
University of Wisconsin-Madison Chemistry Dept.
Progress with Concatenation cDNA Sequencing
Wei Yu and Richard A. Gibbs
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030
Development of a DNA Array System with Focus on Transcription Pathway Prediction
Trey Ideker, Richard Karp, and Leroy Hood
University of Washington, Department of Molecular Biotechnology, Health Sciences Building Box 357730, Seattle, WA, 98195
DNA Sample Manipulation and Automation
Trevor L. Hawkins¹, Laurent Jacotat² , Mary Pat Reeve¹ and Kevin McKernan²
1 Integrated Genomics Technologies. 800 Research Parkway, Meriden, CT
Improved Analysis of Comparative Genomic Hybridization Data by Bivariate Image Analysis
Stefan Burde and Babetta L. Marrone
Los Alamos National Laboratory, Los Alamos, NM 87545

Sequencing Technologies Table of Contents of abstracts from the DOE Human Genome Program Contractor-Grantee Workshop VI November 9-13, 1997, Santa Fe, NM

Table of Contents

of abstracts from the DOE Human Genome Program Contractor-Grantee Workshop VI November 9-13, 1997, Santa Fe, NM

Sequencing Technologies
Table of Contents

of abstracts from the
DOE Human Genome Program Contractor-Grantee Workshop VI
November 9-13, 1997, Santa Fe, NM

of abstracts from the
DOE Human Genome Program Contractor-Grantee Workshop VI
November 9-13, 1997, Santa Fe, NM