In the News
Genomes to Life
OASCR and GTL
DOE Microbial Cell Project
Human Genome Draft
Genome Perspective
Honor for DeLisi
New NIH Institute
Structural Genomics
Imaging Structures
Synchrotron Use
Proteome Organisation
Breast Cancer Research
Gene Expressions Used
Nuclear Medicine
Nuclear Medicine Labs
Toxicogenomics Center
Kettering Prize
Zeta Phi Beta Conference
Microbial Genomes
Sloan-DOE Fellowships
Ribosomes Illuminated
In Memoriam: Walter Goad

Comparative Genomics
Model Organism Studies
Sushi Delicacy
Arabidopsis Sequence
AAAS Prize
Microbial Conference
Flyer; "Microbe Month"
VISTA Software
Mouse
ORNL Mouse Program
MicroCAT Scanner Used
Draft Sequence Achieved
NCBI Mouse Resources
Human-Mouse Comparisons
MGI Allele Searching

Web, Publications, Resources
Next-Generation Computing
HGMIS Resources
NSF QSB Report
Structural Biology Basics
Minorities and the HGP
HGP Educational Kit
Testing, Counseling Resources
Biotech, ELSI Websites
Biotech Encyclopedia
ASM Report
Nature Yearbook
Next Wave Publication
High-School Curriculum
Education CD-ROMs
Exploring DNA in the Classroom

Funding
US Genome Research Funding
UK Scholarships, PostDocs

Meeting Calendars & Acronyms
Genome and Biotechnology Meetings
Training Courses and Workshops
Acronyms

HGN archives and subscriptions

Human Genome Project Information home

From DNA Sequences to Living Systems

Genomes to Life, Microbial Cell Project Complementary New DOE Programs Explore Critical Life Processes

The complete DNA sequences for organisms ranging from humans to mice and microbes are presenting an even greater scientific challenge to understand how life's component parts function together and are influenced by environmental factors in creating and operating dynamic living systems. DOE, a key player in the genomics revolution, is poised to make important contributions to this next grand scientific quest through the Microbial Cell Project (MCP) and the proposed Genomes to Life (GTL) program.

The MCP takes a whole-genome approach to understanding the function and regulation of all genes for a single living system and the pathways in which the protein products interact. The MCP will play a leading role in GTL, DOE's major new undertaking.

The GTL will build on previous Office of Science research that includes the Human Genome Program and the Microbial Genome Program initiated in 1994. The plan for GTL is to use DNA sequences from both microbes and higher organisms, including humans, to systematically tackle questions about essential life processes conserved across species. Advanced technological and computational resources tested and modeled in the MCP will be used to identify and understand the underlying mechanisms that enable organisms to function in diverse environmental conditions.

In a sense, the MCP is advance reconnaissance for GTL, and the two programs are and will remain closely entwined.

Both GTL and the MCP contribute toward the shifting of biology to a more quantitative science, involving the collection, integration, and dissemination of diverse data and the development of appropriate tools. The two programs will formulate more high-throughput methodologies for simultaneously studying many components of living systems.

The extraordinary applications of this holistic approach will help DOE fulfill its broad missions in energy, environmental remediation, and protection of human health. [For more details on GTL, see color centerfold and http://genomicsgtl.energy.gov; for information on MCP, see article, and http://microbialcellproject.org.]

The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v11n3-4).