General Human Genome Project Papers
- Mapping
and sequencing of structural variation from eight human genomes, Nature
May 1, 2008
- Finishing
the euchromatic sequence of the human genome, Nature Oct. 21,
2004
- Human
genome: Quality assessment of the human genome sequence. Nature
429, 365-368 (27 May 2004)
- Building on the DNA
revolution, April 11, 2003 entire issue of Science with insights
from the completion of the HGP finished sequence
- Double helix
at 50, April 24, 2003 entire issue of Nature with insights from
the completion of the HGP finished sequence
- The
human genome Feb.16, 2001, entire issue of Science with insights
from the completion of the HGP and Celera working draft
- The
human genome Feb.15, 2001, entire issue of Nature with insights
from the completion of the HGP working draft
Individual Chromosome Papers
- Nature
Human Genome Collection, composite of all the human chromosome papers,
2006.
- Human
Chromosome 1 Completed, May 2006.
- Human
Chromosome 3 Completed, April 2006.
- Human
Chromosome 17 Completed, April 2006.
- Human
Chromosome 11 Completed, March 2006.
- Human
Chromosome 12 Completed, March 2006.
- Human
Chromosome 15 Completed, March 2006.
- Human
Chromosome 8 Completed, January 2006.
- Human
Chromosome 4 Completed, April 2005.
- Human
Chromosome 2 Completed, April 2005.
- Human
Chromosome X Completed, March 2005.
- Human
Chromosome 16 Completed, December 2004.
- Human
Chromosome 5 Completed, September 2004.
- Human
Chromosome 9 Completed, May 2004.
- Human
Chromosome 10 Completed, May 2004.
- Human
Chromosome 18 Completed, March 2004.
- Human
Chromosome 19 Completed, March 2004.
- Human
Chromosome 13 Completed, March 2004.
- Human
Chromosome 6 Completed, October 2003.
- Human
Chromosome 7 Completed, July 2003.
- Human Chromosome
Y Completed, June 2003.
- Human
Chromosome 14 Completed, January 2003.
- Human Chromosome
20 Completed, December 2001.
- Human Chromosome 21 Completed,
May 2000
- Human Chromosome 22 Completed: First Human Chromosome
to be Sequenced, December 1999
Papers from 2003 and 2001 Science and Nature
Special HGP Completion Issues [Free Access]
The April 11, 2003 issue of Science
and the April 24, 2003 issue of Nature
(see also: special web
focus) presented a special collection of news, viewpoints, and other articles
to celebrate the 50th anniversary of one of the signpost events of modern biology
-- the publication of the structure of DNA -- and the new directions in molecular
biology that the double-helix discovery has marked out in the subsequent half-century.
The first analyses of the working draft human genome sequence were reported
in the February 16, 2001 issue of Science and February 15, 2001 issue
of Nature. The papers from
Nature included initial sequence analyses generated by the publicly sponsored
Human Genome Project, while Science
publications focused on the draft sequence reported by the private company,
Celera Genomics.
Because of the importance of these landmark papers, both Science and
Nature have provided free and unrestricted access to all articles. An
index and links follow.
2003 HGP Completion Papers
Introduction
Barbara R. Jasny and Leslie Roberts
Science Apr 11 2003: 277
| Full Text
| PDF |
The Human Genome Project: Lessons from Large-Scale
Biology
Francis S. Collins, Michael Morgan, Aristides Patrinos
Science Apr 11 2003: 286
| Summary
| Full Text
| PDF |
Realizing the Potential of the Genome Revolution: The
Genomes to Life Program
Marvin E. Frazier, Gary M. Johnson, David G. Thomassen, Carl E. Oliver, Aristides
Patrinos
Science Apr 11 2003: 290
| Summary
| Full Text
| PDF |
A Vision for the Future of Genomics Research
Francis S. Collins, Eric D. Green, Alan E. Guttmacher, Mark S. Guyer
A blueprint for the genomic era.
Nature Apr 24 2003: 835
Full
text | PDF
(1072k)
Genetics and the Making of Homo sapiens
Sean B. Carroll
Nature Apr 24 2003: 849
Summary
| Full
text | PDF
(310k)
Genome Sequencing: Revelations from a Bread Mould
Jonathan Arnold, Nelson Hilton
Nature Apr 24 2003: 821
Full
text | PDF
(90k)
Genome Sequence and Analysis Papers
A physical map of the human genome
The International Human Genome Mapping Consortium
Nature 409, 934-941 (15 February 2001)
| Summary
| Full
Text | PDF
|
The sequence of the human genome
The Celera Genomics Sequencing Team
Science Feb 16 2001: 1304-1351.
[Abstract]
[Full Text]
[Supplemental
Data]
The physical maps for sequencing human chromosomes 1, 6,
9, 10, 13, 20 and X
D. R. Bentley, et al.
Nature 409, 942-943 (15 February 2001)
| First
Paragraph | Full
Text | PDF
|
A physical map of the human Y chromosome
Charles A. Tilford, et al.
Nature 409, 943-945 (15 February 2001)
| First
Paragraph | Full
Text | PDF
|
A high-resolution map of human chromosome 12
Kate T. Montgomery, et al.
Nature 409, 945-946 (15 February 2001)
| First
Paragraph | Full
Text | PDF
|
A physical map of human chromosome 14
Thomas Brüls, et al.
Nature 409, 947-948 (15 February 2001)
| First
Paragraph | Full
Text | PDF
|
Integration of telomere sequences with the draft human
genome sequence
H. C. Riethman, et al.
Nature 409, 948-951 (15 February 2001)
| First
Paragraph | Full
Text | PDF
|
Comparison of human genetic and sequence-based physical
maps
Adong Yu, et al.
Nature 409, 951-953 (15 February 2001)
| First
Paragraph | Full
Text | PDF
|
Integration of cytogenetic landmarks into the draft sequence
of the human genome
V. G. Cheung, et al.
Nature 409, 953-958 (15 February 2001)
| First
Paragraph | Full
Text | PDF
|
Mining the draft human genome
Ewan Birney, et al.
Nature 409, 827-828 (15 February 2001)
| Summary
| Full
Text | PDF
|
Keeping time with the human genome
Jonathan D. Clayton, et al.
Nature 409, 829-831 (15 February 2001)
| Summary
| Full
Text | PDF
|
Expressing the human genome
Rossella Tupler, et al.
Nature 409, 832-833 (15 February 2001)
| Summary
| Full
Text | PDF
|
Functional annotation of mouse genome sequences
Joseph H. Nadeau, et al.
Science Feb 16 2001: 1251-1255.
[Summary]
[Full Text]
A genomic perspective on membrane compartment organization
Jason B. Bock, et al.
Nature 409, 839-841 (15 February 2001)
| Summary
| Full
Text | PDF
|
Genomics, the cytoskeleton and motility
Thomas D. Pollard
Nature 409, 842-843 (15 February 2001)
| Summary
| Full
Text | PDF
|
Can sequencing shed light on cell cycling?
Andrew W. Murray, et al.
Nature 409, 844-846 (15 February 2001)
| Summary
| Full
Text | PDF
|
Evolutionary analyses of the human genome
Wen-hsiung Li, et al.
Nature 409, 847-849 (15 February 2001)
| Summary
| Full
Text | PDF
|
Experimental annotation of the human genome using microarray
technology
D. D. Shoemaker, et al.
Nature 409, 922-927 (15 February 2001)
| Summary
| Full
Text | PDF
|
Guide to the draft human genome
Tyra G. Wolfsberg, et al.
Nature 409, 824-826 (15 February 2001)
| Summary
| Full
Text | PDF
|
Analysis of the Genome Papers --what
other scientists are saying
What if there are only 30,000 human genes?
Jean-Michel Claverie
Science Feb 16 2001: 1255-1257.
[Summary]
[Full Text]
Making sense of the sequence
David J. Galas
Science Feb 16 2001: 1257-1260.
[Summary] [Full
Text]
Our genome unveiled
David Baltimore
Nature 409, 814-816 (15 February 2001)
| Full
Text | PDF|
Genome speak
Peer Bork, et al.
Nature 409, 815 (15 February 2001)
| Full
Text | PDF
|
The maps: Clone by clone by clone
Maynard V. Olson
The public project's sequencing strategy involved producing a map of the human
genome and then pinning sequence to it. This helps to avoid errors in the sequence,
especially in repetitive regions.
Nature 409, 816-818 (15 February 2001)
| Full
Text | PDF
|
The draft sequences: Filling in the gaps
Peer Bork, et al.
Nature 409, 818-820 (15 February 2001)
| Full
Text | PDF
|
The draft sequences: Comparing species
Gerald M. Rubin
Nature 409, 820-821 (15 February 2001)
| Full
Text | PDF
|
Medicine and the New Genomics
Dissecting human disease in the postgenomic era
Leena Peltonen and Victor A. McKusick
Science Feb 16 2001: 1224-1229.
[Summary] [Full
Text]
...to a future of genetic medicine
Aravinda Chakravarti
Nature 409, 822-823 (15 February 2001)
| Full
Text | PDF
|
A genomic view of immunology
Aude M. Fahrer, et al.
Nature 409, 836-838 (15 February 2001)
| Summary
| Full
Text | PDF
|
Cancer and genomics
P. Andrew Futreal, et al.
Nature 409, 850-852 (15 February 2001)
| Summary
| Full
Text | PDF
|
Human disease genes
Gerardo Jimenez-Sanchez, et al.
Nature 409, 853-855 (15 February 2001)
| Summary
| Full
Text | PDF
|
SNPs
A map of human genome sequence variation containing 1.42
million single nucleotide polymorphisms
The International SNP Map Working Group
Nature 409, 928-933 (15 February 2001)
| Summary
| Full
Text | PDF
|
Single nucleotide polymorphisms: From the evolutionary
past...
Mark Stoneking
Nature 409, 821-822 (15 February 2001)
| Full
Text | PDF
|
Behavioral Genomics
Toward behavioral genomics
Peter McGuffin, et al.
Science Feb 16 2001: 1232-1249. [Summary]
[Full Text]
Learning about addiction from the genome
Eric J. Nestler, et al.
Nature 409, 834-835 (15 February 2001)
| Summary
| Full
Text | PDF
|
Bioinformatics
Bioinformatics--Trying to swim in a sea of data
David S. Roos
Science Feb 16 2001: 1260-1261. [Summary]
[Full Text]
Computational comparison of two draft sequences of the
human genome
John Aach, et al.
Nature 409, 856-859 (15 February 2001)
| Summary
| Full
Text | PDF
|
Are you ready for the revolution?
Declan Butler
Nature 409, 758-760 (15 February 2001)
| Full
Text | PDF
|
Ethical, Legal, and Social Issues
The human genome and our view of ourselves
Svante Pääbo
Science Feb 16 2001: 1219-1220.
[Summary]
[Full Text]
Political issues in the genome era
James M. Jeffords and Tom Daschle
Science Feb 16 2001: 1249-1251.
[Summary] [Full
Text]
What's Next? Future
Proteomics in genomeland
Stanley Fields
Science Feb 16 2001: 1221-1224.
[Summary] [Full
Text]
Watching genes build a body
Gretchen Vogel
Science Feb 16 2001: 1181.
[Summary] [Full
Text]
What's next for the genome centers?
Elizabeth Pennisi
Science Feb 16 2001: 1204-1207.
[Summary] [Full
Text]
Hunting for collaborators of killer toxins
Jocelyn Kaiser
Science Feb 16 2001: 1207.
[Summary] [Full
Text]
Public vs Private / Biotechnology Industry
The human genome
Elizabeth Pennisi
Science Feb 16 2001: 1177-1180.
[Summary] [Full
Text]
Comparison shopping
Eliot Marshall
Science Feb 16 2001: 1180-1181.
[Summary] [Full
Text]
Genomania meets the bottom line
David Malakoff and Robert F. Service
Science Feb 16 2001: 1193-1203.
[Summary] [Full
Text]
Can data banks tally profits?
Robert F. Service
Science Feb 16 2001: 1203.
[Summary] [Full
Text]
Will a smaller genome complicate the patent chase?
David Malakoff
Science Feb 16 2001: 1194.
[Summary]
[Full Text]
History of the Project
Controversial from the start
Leslie Roberts
Science Feb 16 2001: 1182-1188.
[Summary] [Full
Text]
A history of the human genome project
Leslie Roberts, et al.
Science Feb 9 2001: 1195.
[Summary] [Full
Text]
In their own words
Science Feb 9 2001: 1196.
[Summary] [Full
Text]
What a long, strange trip it's been
Nature 409, 756 - 757 (15 February 2001)
| Full
Text | PDF
|
Editorials
The human genome
Editorial by Barbara R. Jasny and Donald Kennedy
Science Feb 16 2001: 1153.
[Summary]
Human genomes, public and private
Editorial
Nature Feb 15 2001: 409
[Full
Text]
Other
Molecular structure of nucleic acids: A structure for deoxyribose
nucleic acid
WATSON, J. D. & CRICK, F. H. C.
Nature 171, 737-734 (1953)
| Full Text
| PDF
|
Science genome map
Science Feb 16 2001: 1218.
[Summary] [Full
Text]
Funny genes / The DNA vault / Genome hubs / Genomes for
all
Science Feb 16 2001: 1163
[Full Text]
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