This NIJ Research Report explains the value of analyzing DNA samples using time-of-flight mass spectrometry (TOFMS), a technology that can process several thousand DNA samples daily with greater accuracy than conventional electrophoresis methods. Not only was TOFMS found to rapidly and accurately type single tandem repeats, it also proved effective in analyzing single nucleotide polymorphisms. Furthermore, TOFMS was more cost efficient and showed an improved ability to handle degraded DNA samples.