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General Human Genome Project Papers

• Mapping and sequencing of structural variation from eight human genomes, Nature May 1, 2008
• Finishing the euchromatic sequence of the human genome, Nature Oct. 21, 2004
• Human genome: Quality assessment of the human genome sequence. Nature 429, 365-368 (27 May 2004)
• Building on the DNA revolution, April 11, 2003 entire issue of Science with insights from the completion of the HGP finished sequence
• Double helix at 50, April 24, 2003 entire issue of Nature with insights from the completion of the HGP finished sequence
• The human genome Feb.16, 2001, entire issue of Science with insights from the completion of the HGP and Celera working draft
• The human genome Feb.15, 2001, entire issue of Nature with insights from the completion of the HGP working draft

Individual Chromosome Papers

• Nature Human Genome Collection, composite of all the human chromosome papers, 2006.
• Human Chromosome 1 Completed, May 2006.
• Human Chromosome 3 Completed, April 2006.
• Human Chromosome 17 Completed, April 2006.
• Human Chromosome 11 Completed, March 2006.
• Human Chromosome 12 Completed, March 2006.
• Human Chromosome 15 Completed, March 2006.
• Human Chromosome 8 Completed, January 2006.
• Human Chromosome 4 Completed, April 2005.
• Human Chromosome 2 Completed, April 2005.
• Human Chromosome X Completed, March 2005.
• Human Chromosome 16 Completed, December 2004.
• Human Chromosome 5 Completed, September 2004.
• Human Chromosome 9 Completed, May 2004.
• Human Chromosome 10 Completed, May 2004.
• Human Chromosome 18 Completed, March 2004.
• Human Chromosome 19 Completed, March 2004.
• Human Chromosome 13 Completed, March 2004.
• Human Chromosome 6 Completed, October 2003.
• Human Chromosome 7 Completed, July 2003.
• Human Chromosome Y Completed, June 2003.
• Human Chromosome 14 Completed, January 2003.
• Human Chromosome 20 Completed, December 2001.
• Human Chromosome 21 Completed, May 2000
• Human Chromosome 22 Completed: First Human Chromosome to be Sequenced, December 1999

The April 11, 2003 issue of Science and the April 24, 2003 issue of Nature (see also: special web focus) presented a special collection of news, viewpoints, and other articles to celebrate the 50th anniversary of one of the signpost events of modern biology -- the publication of the structure of DNA -- and the new directions in molecular biology that the double-helix discovery has marked out in the subsequent half-century.

The first analyses of the working draft human genome sequence were reported in the February 16, 2001 issue of Science and February 15, 2001 issue of Nature. The papers from Nature included initial sequence analyses generated by the publicly sponsored Human Genome Project, while Science publications focused on the draft sequence reported by the private company, Celera Genomics.

Because of the importance of these landmark papers, both Science and Nature have provided free and unrestricted access to all articles. An index and links follow.

2003 HGP Completion Papers

Introduction
Barbara R. Jasny and Leslie Roberts
Science Apr 11 2003: 277
| Full Text | PDF |

The Human Genome Project: Lessons from Large-Scale Biology
Francis S. Collins, Michael Morgan, Aristides Patrinos
Science Apr 11 2003: 286
| Summary | Full Text | PDF |

Realizing the Potential of the Genome Revolution: The Genomes to Life Program
Marvin E. Frazier, Gary M. Johnson, David G. Thomassen, Carl E. Oliver, Aristides Patrinos
Science Apr 11 2003: 290
| Summary | Full Text | PDF |

A Vision for the Future of Genomics Research
Francis S. Collins, Eric D. Green, Alan E. Guttmacher, Mark S. Guyer
A blueprint for the genomic era.
Nature Apr 24 2003: 835
Full text | PDF (1072k)

Genetics and the Making of Homo sapiens
Sean B. Carroll
Nature Apr 24 2003: 849
Summary | Full text | PDF (310k)

Genome Sequencing: Revelations from a Bread Mould
Jonathan Arnold, Nelson Hilton
Nature Apr 24 2003: 821
Full text | PDF (90k)

A physical map of the human genome
The International Human Genome Mapping Consortium
Nature 409, 934-941 (15 February 2001)
| Summary | Full Text | PDF |

The sequence of the human genome
The Celera Genomics Sequencing Team
Science Feb 16 2001: 1304-1351.
[Abstract] [Full Text] [Supplemental Data]

Functional annotation of mouse genome sequences
Joseph H. Nadeau, et al.
Science Feb 16 2001: 1251-1255.
[Summary] [Full Text]

A genomic perspective on membrane compartment organization
Jason B. Bock, et al.
Nature 409, 839-841 (15 February 2001)
| Summary | Full Text | PDF |

Genomics, the cytoskeleton and motility
Thomas D. Pollard
Nature 409, 842-843 (15 February 2001)
| Summary | Full Text | PDF |

Can sequencing shed light on cell cycling?
Andrew W. Murray, et al.
Nature 409, 844-846 (15 February 2001)
| Summary | Full Text | PDF |

Evolutionary analyses of the human genome
Wen-hsiung Li, et al.
Nature 409, 847-849 (15 February 2001)
| Summary | Full Text | PDF |

Experimental annotation of the human genome using microarray technology
D. D. Shoemaker, et al.
Nature 409, 922-927 (15 February 2001)
| Summary | Full Text | PDF |

Guide to the draft human genome
Tyra G. Wolfsberg, et al.
Nature 409, 824-826 (15 February 2001)
| Summary | Full Text | PDF |

What if there are only 30,000 human genes?
Jean-Michel Claverie
Science Feb 16 2001: 1255-1257.
[Summary] [Full Text]  

Making sense of the sequence
David J. Galas
Science Feb 16 2001: 1257-1260.
[Summary] [Full Text]

Our genome unveiled
David Baltimore
Nature 409, 814-816 (15 February 2001)
| Full Text | PDF|

Genome speak
Peer Bork, et al.
Nature 409, 815 (15 February 2001)
| Full Text | PDF |

The maps: Clone by clone by clone
Maynard V. Olson
The public project's sequencing strategy involved producing a map of the human genome and then pinning sequence to it. This helps to avoid errors in the sequence, especially in repetitive regions.
Nature 409, 816-818 (15 February 2001)
| Full Text | PDF |

The draft sequences: Filling in the gaps
Peer Bork, et al.
Nature 409, 818-820 (15 February 2001)
| Full Text | PDF |

The draft sequences: Comparing species
Gerald M. Rubin
Nature 409, 820-821 (15 February 2001)
| Full Text | PDF |

Dissecting human disease in the postgenomic era
Leena Peltonen and Victor A. McKusick
Science Feb 16 2001: 1224-1229.
[Summary] [Full Text]  

...to a future of genetic medicine
Aravinda Chakravarti
Nature 409, 822-823 (15 February 2001)
| Full Text | PDF |

A genomic view of immunology
Aude M. Fahrer, et al.
Nature 409, 836-838 (15 February 2001)
| Summary | Full Text | PDF |

Human disease genes
Gerardo Jimenez-Sanchez, et al.
Nature 409, 853-855 (15 February 2001)
| Summary | Full Text | PDF |

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
The International SNP Map Working Group
Nature 409, 928-933 (15 February 2001)
| Summary | Full Text | PDF |

Single nucleotide polymorphisms: From the evolutionary past...
Mark Stoneking
Nature 409, 821-822 (15 February 2001)
| Full Text | PDF |

Toward behavioral genomics
Peter McGuffin, et al.
Science Feb 16 2001: 1232-1249. [Summary] [Full Text]  

Learning about addiction from the genome
Eric J. Nestler, et al.
Nature 409, 834-835 (15 February 2001)
| Summary | Full Text | PDF |

Bioinformatics--Trying to swim in a sea of data
David S. Roos
Science Feb 16 2001: 1260-1261. [Summary] [Full Text]  

Computational comparison of two draft sequences of the human genome
John Aach, et al.
Nature 409, 856-859 (15 February 2001)
| Summary | Full Text | PDF |

Are you ready for the revolution?
Declan Butler
Nature 409, 758-760 (15 February 2001)
| Full Text | PDF |

The human genome and our view of ourselves
Svante Pääbo
Science Feb 16 2001: 1219-1220.
[Summary] [Full Text]

Political issues in the genome era
James M. Jeffords and Tom Daschle
Science Feb 16 2001: 1249-1251.
[Summary] [Full Text]  

Proteomics in genomeland
Stanley Fields
Science Feb 16 2001: 1221-1224.
[Summary] [Full Text]  

Watching genes build a body
Gretchen Vogel
Science Feb 16 2001: 1181.
[Summary] [Full Text]  

What's next for the genome centers?
Elizabeth Pennisi
Science Feb 16 2001: 1204-1207.
[Summary] [Full Text]

Hunting for collaborators of killer toxins
Jocelyn Kaiser
Science Feb 16 2001: 1207.
[Summary] [Full Text]  

The human genome
Elizabeth Pennisi
Science Feb 16 2001: 1177-1180.
[Summary] [Full Text]  

Genomania meets the bottom line
David Malakoff and Robert F. Service
Science Feb 16 2001: 1193-1203.
[Summary] [Full Text]  

Can data banks tally profits?
Robert F. Service
Science Feb 16 2001: 1203.
[Summary] [Full Text]

Will a smaller genome complicate the patent chase?
David Malakoff
Science Feb 16 2001: 1194.
[Summary] [Full Text]

Controversial from the start
Leslie Roberts
Science Feb 16 2001: 1182-1188.
[Summary] [Full Text]

Sidebars
• Objection #1: Big biology is bad biology
  Robert F. Service
  Science Feb 16 2001: 1182. [Summary] [Full Text]  
• Finding the talismans that protect against infection
  Martin Enserink
  Science Feb 16 2001: 1183. [Summary] [Full Text]  
• Objection #2: Why sequence the junk?
  Gretchen Vogel
  Science Feb 16 2001: 1184. [Summary] [Full Text]
• Unsung heroes
  Science Feb 16 2001: 1207. [Summary] [Full Text]  
• Nailing down cancer culprits
  Jean Marx
  Science Feb 16 2001: 1185. [Summary] [Full Text]  
• Objection #3: Impossible to do
  Robert F. Service
  Science Feb 16 2001: 1186. [Summary] [Full Text]  
• A parakeet genome project?
  Gretchen Vogel
  Science Feb 16 2001: 1187. [Summary] [Full Text]  
• Brain calls dibs on many genes
  Laura Helmuth
  Science Feb 16 2001: 1188. [Summary] [Full Text]  
• Sharing the glory, not the credit
  Eliot Marshall
  Science Feb 16 2001: 1189-1193. [Summary] [Full Text]  
• Celera and Science spell out data access provisions
  Eliot Marshall
  Science Feb 16 2001: 1191. [Summary] [Full Text]  
• Bermuda rules: Community spirit, with teeth
  Eliot Marshall
  Science Feb 16 2001: 1192. [Summary] [Full Text]  

A history of the human genome project
Leslie Roberts, et al.
Science Feb 9 2001: 1195.
[Summary] [Full Text]  

In their own words
Science Feb 9 2001: 1196.
[Summary] [Full Text]  

What a long, strange trip it's been
Nature 409, 756 - 757 (15 February 2001)
| Full Text | PDF |

The human genome
Editorial by Barbara R. Jasny and Donald Kennedy
Science Feb 16 2001: 1153.
[Summary]

Science genome map
Science Feb 16 2001: 1218.
[Summary] [Full Text]

Funny genes / The DNA vault / Genome hubs / Genomes for all
Science Feb 16 2001: 1163
[Full Text]

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