Baum MK, Campa A, Lai S, Lai H, Yang Z, Sales S, King K, Page B; International Conference on AIDS.
Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. ThPeB7323.
Florida International University, Miami, FL, United States
BACKGROUND: Zinc (Zn) deficiency is associated with immune abnormalities and increased susceptibility to infections. While Zn deficiency has been observed in various HIV+ populations, including those on HAART, its relevance in HIV disease is not understood. The objective of this study was to evaluate whether dietary Zn intake is related to Zn deficiency and mortality in HIV+ drug users. METHOD: Immunological, nutritional and clinical profiles of 118 HIV+ drug users were assessed every 6 months in Miami, Florida between 1994-98. HIV-related mortality was confirmed with data from the Medical Examiner. Zn intake was obtained by the Willet's food frequency questionnaire. The effect of dietary Zn intake on mortality was determined by a multivariate Cox proportional hazards model with dietary Zn and CD4 cell count as time-dependent covariates. RESULTS: HIV-related death occurred in 22 individuals during the course of the study. Mean intake of Zn (10.1 mg/day+/-5.5) was below the recommendations for healthy US population (RDA is 15 mg/day for men, 12 mg/day for women). Zn deficiency (plasma Zn
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antiretroviral Therapy, Highly Active
- CD4 Lymphocyte Count
- Female
- Florida
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Male
- Nutritional Status
- Proportional Hazards Models
- Zinc
- mortality
Other ID:
UI: 102250981
From Meeting Abstracts