Fulton P, Phillips P; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 239 (abstract no. Th.B.468).
University of British Columbia, Vancouver, BC, Canada
OBJECTIVE: To document the development of clinical relapse associated with in vitro resistance of C. albicans to fluconazole. PATIENTS, METHODS, AND RESULTS: A 28 year old female was diagnosed with AIDS, thrush and Candida esophagitis in 1988. Initial treatment and suppressive therapy with topical clotrimazole was effective, although compliance was limited. One year later fluconazole 150 mg orally every 3 weeks was initiated, and clotrimazole was discontinued. The initial response was prompt; however, progressively shorter dosage intervals were required to control mucosal candidiasis. After 6 months of fluconazole, and while receiving 100 mg/day for 2 months she experienced a relapse of thrush confirmed by examination, gram-stained smear and culture. The minimum inhibitory concentration of fluconazole for the isolate was 25 ug/ml. CONCLUSION: Despite the poor correlation between in vitro susceptibility and clinical efficacy for fluconazole, this case indicates the potential for the development of resistance. It is unclear whether or not intermittent dosing may have been a contributing factor.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Animals
- Antigens, Fungal
- Candida albicans
- Candidiasis
- Candidiasis, Oral
- Clotrimazole
- Esophagitis
- Female
- Fluconazole
- Humans
- In Vitro
- Microbial Sensitivity Tests
- Songbirds
- etiology
- immunology
- therapy
Other ID:
UI: 102182047
From Meeting Abstracts