[Federal Register: August 13, 2001 (Volume 66, Number 156)]
[Notices]
[Page 42548-42549]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr13au01-68]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institute of Health
Public Health Service
The National Toxicology Program (NTP), National Institute of
Environmental Health Sciences (NIEHS), Center for the Evaluation of
Risks to Human Reproduction (CERHR) (1) announces an upcoming
evaluation of 1-bromopropane (CASRN: 106-94-5) and 2-bromopropane
(CASRN: 75-26-3), (2) solicits the nomination of individuals qualified
to serve on an Expert Panel, and (3) requests public input on these
chemicals.
Background
The NTP and the NIEHS established the NTP CERHR (Federal Register,
Vol. 63, No. 239, page 68782) in June 1998. The purpose of the CERHR is
to provide scientifically-based, uniform assessments of the potential
for adverse effects on reproduction and development caused by agents to
which humans may be exposed. A scientific expert panel reviews the
scientific evidence on the chemical(s) under review, receives public
comments, and then prepares a report on the chemical(s). The Expert
Panel Report is made available for review and public comment on the
CERHR web site (http://cerhr.niehs.nih.gov) and upon request from Dr.
Michael Shelby, CERHR Director (see address below). Following the
expert panel evaluation, the NTP staff prepares the NTP Center Report
on the evaluated chemical(s). This report integrates background
information on the chemical(s), findings of the expert panel, and a
discussion of any pertinent studies published after the expert panel's
evaluation. The NTP Center Report includes all public comments received
on the Expert Panel Report. The NTP Center Report is made publicly
available and is distributed to interested stakeholders and appropriate
regulatory and research agencies. A summary of the complete review
process was recently published in the Federal Register (Vol. 66, No.
136, pages 37047-37048) and can be found on the CERHR web site. A
hardcopy may be requested from CERHR at the address given below.
Evaluation of 1- and 2-Bromopropane
1-Bromopropane (CASRN: 106-94-5) and 2-bromopropane (CASRN: 75-26-
3) have been selected for the third CERHR expert panel evaluation. 1-
Bromopropane is used as a spray adhesive; as a solvent for fats, waxes,
or resins; and as an intermediate in the synthesis of other compounds.
2-Bromopropane is used in the synthesis of pharmaceuticals, dyes, and
other compounds and is present as a contaminant in 1-bromopropane.
Bromopropanes are being considered as replacement chemicals for
hydrochlorofluorocarbons and chlorinated solvents. The scientific
database on these chemicals includes studies on neurotoxicity,
reproductive toxicity, and occupational exposures. 2-Bromopropane is
reported to be a reproductive toxicant in humans. It is anticipated
that the expert panel evaluation of 1- and 2-bromopropane will occur
December 5-7, 2001, in Alexandria, VA.
An expert panel of approximately 12 scientists, selected for their
scientific expertise in various aspects of reproductive and
developmental toxicology and other relevant areas of science, will
conduct these evaluations. The expert panel meeting will be open to the
public with an opportunity scheduled for oral public comment.
Request for Public Input
(1) The CERHR invites input from the public on 1- and 2-
bromopropane including toxicology information from completed and
ongoing studies, information on planned studies, as well as current
production data, human exposure information, use patterns, and
environmental occurrence. Information and comments should be forwarded
to Dr. Shelby at the address given below. Information and comments
received by September 27, 2001 will be made available to CERHR staff
and the Expert Panel and considered in the evaluation.
(2) The CERHR also invites nominations of qualified scientists to
serve on the Bromopropane Expert Panel. Panelists are primarily drawn
from the CERHR Expert Registry and/or the nomination of other
scientists who meet the criteria for listing in that registry. Criteria
for listing in the CERHR Expert Registry listing include: formal
academic training and experience in a relevant scientific field,
publications in peer-reviewed journals, membership in relevant
professional societies, certification by an appropriate scientific
Board or other entities, and participation in similar committee
activities. Scientists on the expert panel will represent a wide range
of expertise including developmental toxicology, reproductive
toxicology, epidemiology, general toxicology, neurotoxicology,
pharmacokinetics, exposure assessment, and biostatistics. Nominations
received by September 27, 2001, publication will be considered for the
Bromopropane Expert Panel and/or inclusion in the CERHR Expert
Registry. Nominations should be forwarded to Dr. Shelby at the address
given below.
Request for Nomination of Chemicals for Future CERHR Reviews
The CERHR welcomes the nomination of chemicals for possible future
evaluation. The nominations can be made through the CERHR's web site
(http://cerhr.niehs.nih.gov) or by contacting Dr. Shelby at the address
given below.
Michael D. Shelby, Ph.D., Director, NTP Center for the Evaluation of
Risks to Human Reproduction, 79 T.W.
[[Page 42549]]
Alexander Drive, Building. 4401, Room 102, P.O. Box 12233, EC-32,
Research Triangle Park, NC 27709 Phone: (919) 541-3455, Fax: (919) 316-
4511, shelby@niehs.nih.gov.
Dated: August 2, 2001.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.
[FR Doc. 01-20190 Filed 8-10-01; 8:45 am]
BILLING CODE 4140-01-P