Mangili A, Gerrior J, Tang A, O'Leary DH, Polack JF, Schaefer EJ, Gorbach SL, Wanke CA; Conference on Retroviruses and Opportunistic Infections (11th : 2004 : San Francisco, Calif.).
Program Abstr Conf Retrovir Oppor Infect 11th 2004 San Franc Calif. 2004 Feb 8-11; 11: abstract no. 738.
Tufts Univ. Sch. of Med., Boston, MA, USA and 2Tufts-New England Med. Ctr., Boston, MA, USA
BACKGROUND: There is concern for increased risk of cardiovascular events in HIV infection. We evaluated risk factors for cardiovascular disease using carotid IMT and CCS as surrogate markers in HIV-infected adults, from a longitudinal study examining nutritional and metabolic parameters.METHODS: Cross-sectional analysis in NFHL participants with carotid IMT (n = 230) and CCS (n = 239). Kruskal-Wallis tests and Spearman's correlation coefficients were calculated.RESULTS: Of the total, 51 (22%) were female, 57 (25%) were not on HAART, 113 (49.1%) smoked, 19 (8.3%) had IDU history. Overall, mean age was 45 years (+/- 7.1), BP 118/76 (+/- 16/10), BMI 26 (+/- 5), total cholesterol (TC) 192 (+/- 60), triglycerides (TG) 234 (+/- 578), CD4 456 (+/- 309), log HIV RNA 3.1 (+/- 1.07). For CCA, 16 (7%) had IMT >0.8 mm; for ICA, 56 (24%) had IMT >0.8 mm. For CCS, 73 (30%) had a score of 0 to 10, 40 (17%) of 10 to 100, 21 (9%) of >100. TG, TC, ApoB, ApoE, and RLPC were significantly higher in men on HAART and TC in women on HAART (p <0.05). IMT and CCS were not significantly different by HAART use (p >0.05); 7 to 26% had abnormal surrogate markers of cardiovascular disease. Of note, duration of HIV infection was correlated overall with CCA IMT and there was a trend for CD4 correlation with CCS in men. Otherwise, traditional cardiovascular disease risk factors, age, SBP, and ApoB were correlated with CCA IMT in both sexes and CCS in men only. Waist was correlated with CCA IMT in men. Insulin resistance and TG were correlated with CCS in women and there was a trend for correlation with BMI. CRP was correlated with CCA IMT and CCS in women. Results for ICA were similar to CCA. [table; see text]CONCLUSIONS: Lipid values were higher for men on HAART, but these do not yet correlate with surrogate markers of cardiovascular disease in this population. Although the significant correlations with IMT and CCS were primarily traditional risk factors, some HIV-specific factors are also observed and may become more evident with prolonged HIV infection and treatment.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Adult
- Antiretroviral Therapy, Highly Active
- Cardiovascular Diseases
- Carotid Artery, Internal
- Cross-Sectional Studies
- Female
- HIV Infections
- HIV Seropositivity
- HIV-1
- Heart
- Humans
- Longitudinal Studies
- Male
- Nutrition Physiology
- Risk Factors
- Tunica Intima
- Tunica Media
- methods
Other ID:
UI: 102270927
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