AMORIM C, MARTINS S, BURATTINI MN, NUCCI M, FISCHMAN O, COLOMBO A; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. J-679.

Univ. Fed. Sao Paulo, Sao Paulo, Brazil

BACKGROUND:Infection is the most frequent complication associated with CVC use. The aim of this study was to evaluate risk factors for Candida spp colonization of CVC placed in critically ill patients (pts). MethodsFrom August 1998 to April 1999, all pts admitted to 2 intensive care units were prospectively evaluated. Pts with previous hospitalization and those who had the catheter in place for more than 48 hours before baseline evaluation were excluded. A total of 23 potential risk factors for colonization of CVC were collected. Samples for culture were obtained every 72 h by swabbing different sites of the extra-cutaneous hub, CVC connections and skin around the CVC exit site. In addition, tip CVC cultures were performed when available. Pts with CVC colonization by Candida where compared to those free of colonization by univariate and multivariate analyses. RESULTS: We evaluated 134 episodes of CVC insertion in 93 pts. The median duration of hospitalization was 10 days. A total of 971 samples were obtained, and the rate of Candida CVC colonization was 20% (28 out of 134 CVC). Skin around the CVC exit site was colonized in 20 episodes, and C. albicans was the most frequent species (55% of cases), followed by C. tropicalis, C. glabrata and C. parapsilosis. By univariate analysis, duration of hospitalization (median 29 vs. 17 days, p=0.02), catheterization (median 10.8 vs. 6.5 days, p<0.001), and antibiotic use (median 22 versus 11 days, p=0.02), and CVC placed in the jugular vein (p=0.03) were risk factors for CVC Candida colonization. After multivariate analysis, only CVC placed in the jugular vein and duration of antibiotic use were significant. There was only one case of candidemia, and the pt was previously colonized by the same species. CONCLUSIONS: We observed a high rate of Candida spp colonization of CVC among critical ill pts. Risk factors were the local of access and duration of antibiotic use.

Publication Types:

• Meeting Abstracts

Keywords:

• Candida
• Candidiasis
• Catheterization, Central Venous
• Critical Illness
• Humans
• Intensive Care Units
• Risk Factors

Other ID:

• GWAIDS0029359

UI: 102268991

From Meeting Abstracts