Batisse D, Eliaszewicz M, Zazoun L, Baudrimont M, Dupont B; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 198 (abstract no. PB0805).
Hopital de l'Institut Pasteur, Paris, France.
AIM: ARN, described till 1985 in non immuno-suppressed patients, occurs frequently in HIV infected population. Our aim was to report 26 cases of ARN in 26 HIV infected patients and to compare these data to literature. METHODOLOGY: We have conducted a retrospective study from 5 ophtalmological departments (Paris, France). RESULTS: ARN was observed in patients with CD4 lymphocytes count under 100/mm3. Decreased vision was the first sign. Examination showed the characteristic triad: vitreous humor inflammation, arteritis and circumferantial afferent necrosis. In 60 to 90%, a viral vesicular eruption precedes of few days the ARN: in most cases VZV infection was concerned. Rarely, a neurological disease is associated. Bilateral (50%) blindness is the main complication (76 to 85%) due to detached retina. Our results suggest that VZV could be implicated in ARN. Diagnosis leads to an urgent anti-viral treatment. No drug is today efficient but foscarnet seems interesting, alone or in association (aciclovir, in situ ganciclovir).
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Acyclovir
- Disease Progression
- Foscarnet
- France
- Ganciclovir
- HIV Infections
- HIV Seropositivity
- Herpesvirus 3, Human
- Humans
- Paris
- Retinal Necrosis Syndrome, Acute
- Retinitis
- Retrospective Studies
Other ID:
UI: 102210261
From Meeting Abstracts