Malessa R, Agelink M, Brockmeyer N, Hengge U, Baumann M, Weiller C; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: B220 (abstract no. PoB 3775).
Dept. of Neurology, Univ. of Essen, FRG.
OBJECTIVE: We investigated the pattern and natural course of HIV-associated changes in the auditory system and the effects of Zidovudine treatment in a 3 year prospective follow up study. METHODS: We compared BAEP (click-stim., 10Hz, 70 dBs1, peaks I, III, V and interpeak latencies IPLs I-III, III-V, I-V) in 29 HIV-seropositive neurological asymptomatic homosexuals (HIVs) and in 27 controls. In 25 patients tests were repeated once in 10 and twice in 15 patients within three years. After study entry 14 patients were treated with Zidovudine, 11 remained untreated. RESULTS: HIVs initially showed a significant delay of the peak I latencies compared to controls. IPLs III-V were significantly higher in HIVs with T-helper cells below 400/nl (p less than 0.05). There was a progressive delay of the peaks I, III, and V and an increase of IPLs I-V (p less than 0.01) during the period of observation. In the treated HIVs no significant progression in the latencies of peak I was found. However, there were no other differences between the treated and untreated group concerning the progressive course of BAEP changes. CONCLUSION: There is progressive impairment of BAEP in HIV-infection. Zidovudine treatment does not substantially alter the natural course of these changes in the auditory system.
Publication Types:
Keywords:
- Evoked Potentials, Auditory, Brain Stem
- Follow-Up Studies
- Humans
- Longitudinal Studies
- therapy
Other ID:
UI: 102199221
From Meeting Abstracts