Chuenchitra C, Rungruengthanakit K, Mason CJ, Markowitz LE, Beyrer C, Kitsiripornchai S, Khamboonruang C, Nitayaphan S, Michael RA, Nelson KE, Maclean I; International Conference on AIDS.

Int Conf AIDS. 1996 Jul 7-12; 11: 162 (abstract no. Mo.C.1623).

AFRIMS, Bangkok, Thailand. Fax: 662-245-0582. E-mail: rmichael@mozart.inet.co.th.

Objectives: 1. Assess differences in regional seroprevalence in Thailand of antibodies to Haemophilus ducreyi. 2. Using case-control methodology, assess the risk for HIV-1 infection of seroprevalence antibodies to H. ducreyi. Methods: Sample: 1. Stratified random samples of over 360 serum specimens from each region in Thailand of 21 year old males entering service with the Royal Thai Army in November 1994. 2. A stratified random samples of HIV-1 seropositive and over 350 seronegative samples from each region from the same population. Laboratory: An ELISA using a soluble lipooligosaccharide antigen prepared from 2 strains of H. ducreyi was used for the detection of antibodies to H. ducreyi. Results: Seroprevalence. Defining a standardized ELISA OD greater than 0.4 as positive, the regional seroprevalence of antibodies to H. ducreyi ranged from a low of 7.9% (31/391) in the Northeast (NE) to 13.6% (49/361) (p is less than 0.05 compared to NE) in the South to a high of 14.5% (56/386) (p is less than 0.01 compared to NE) in the Upper North. Risk factors: Defining a standardized initial & repeat ELISA OD greater than 0.4 as positive, the regional odds ratios for HIV-1 infection in antibody positive individuals ranged from 2.00 (95% confidence interval (CI): 0.20-10.43) in the Lower North, to 7.97 (95% CI: 3.18, 20.84)(p is less than 0.001) in the Upper North. Conclusions: There is significant regional variation within Thailand of seroprevalence in antibodies to Haemophilus ducreyi corresponding with the known regional variation of HIV-1 seroprevalence. Exposure to Haemophilus ducreyi is a significant risk factor in Thailand for HIV-1 seroprevalence as has been previously documented for Africa.

Publication Types:

• Meeting Abstracts

Keywords:

• Africa
• Antibodies
• Chancroid
• Enzyme-Linked Immunosorbent Assay
• HIV Antibodies
• HIV Infections
• HIV Seropositivity
• HIV Seroprevalence
• Haemophilus ducreyi
• Humans
• Male
• Risk Factors
• Seroepidemiologic Studies
• Thailand

Other ID:

• 96921669

UI: 102217568

From Meeting Abstracts