Ramirez Amador V, esquivel Pedraza L, Sierra-Madero J, Soto-Ramirez L, Gonzalez Ramirez I, Anaya Saavedra G, Ponce de Leon-Rosales S; International Conference on AIDS.
Int Conf AIDS. 2000 Jul 9-14; 13: abstract no. MoPeB2272.
V. Ramirez Amador, Universidad Autonoma Metropolitana, Mexico, Tel.: +52 001 5 606 1781, Fax: +52 001 5 666 15 02, E-mail: rava1863@cueyatl.uam.mx
B`ackground: The purpose of the present study was to determine the association of HIV-RNA plasma levels and CD4+ T cell counts with the development of oral clinical markers of HIV progression such as oral candidosis (OC) and hairy leukoplakia (HL). Methods: A prospective cohort study approved by the Ethical and Research Committee of the INNSZ, was performed at the AIDS clinic of the Infectious Diseases Department of the INNSZ, in Mexico City from April 1999 to present. HIV-infected individuals without OC or HL, with no antiretroviral therapy using protease inhibitors were included in the study. A basal oral examination was done at initial of the study and every month, during two years. CD4 counts and HIV-RNA levels were obtained at baseline and every six months or at the onset of HL or OC. Other variables included were: clinical status, history of smoking, and use of nucleoside and non nucleoside analogs. Enrolled patients were followed until the development of OC or HL. The statistical analysis included the longitudinal behaviour of HIV-RNA plasma levels and CD4+ T counts. The relationship between OC or HL, CD4+ count and viral load estimates was measured through logistic procedures. Results: In this ongoing study, 65 HIV-infected patients (47 males, 18 females), mean age of 34 years old (SD = 8.3), have been enrolled, and followed for a period of eight months. A total of 42 (66%) patients were at initial stages of HIV infection. Forty three (68%) patients were not receiving antiretrovirals. The median basal viral load estimates were 20,703 copies/mL (range 0-322,783) and for the CD4 counts were 301 (range 15-1,067). At follow-up, eight (61%) patients have developed OC, four (31%) HL, and one (8%) developed both lesions. The median CD4 count of those who developed oral lesions was of 259 (range 17-899) and their median viral load was of 44,327 (range 51-445,226) copies/mL. Conclusions: The onset of OC and HL seemed to be related with an increase of viral load and a decrease of CD4 counts in this ongoing study. Further data will be necessary to precise these possible associations.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Biological Markers
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Candidiasis, Oral
- Cohort Studies
- Disease Progression
- Female
- HIV
- HIV Infections
- HIV Seropositivity
- Humans
- Leukoplakia, Hairy
- Longitudinal Studies
- Male
- Mexico
- Prospective Studies
- Research
- Viral Load
- organization & administration
Other ID:
UI: 102237872
From Meeting Abstracts