Bravo R, Arroyo E, Sampelayo T, Gurbindo D, Arnaiz-Villena A, Gomez-Reino F; International Conference on AIDS.

Int Conf AIDS. 1993 Jun 6-11; 9: 312 (abstract no. PO-B05-1058).

Centro de Transfusion de Madrid.

Some HLA antigens has been associated with susceptibility to HIV-1 infection or with a rapid disease progression in infected adults. Since the vertical transmission of HIV infection is about 15%, we tested if some specific HLA antigens are associated with infectivity or protection. HLA antigens were studied in samples from 44 children born from HIV-seropositive mothers, and 450 healthy controls. Blood was collected after 15 months of birth in all them. Among infants from HIV+ mothers, 28 were HIV-seropositive and showed symptoms of HIV-1 infection. The remain 16 children born from HIV+ mothers seroreverted and were in good health. PCR results agree with the clinical and serological status in these cases. Prevalence of HLA-B35 was statistically not higher among HIV-infected children comparing with healthy controls (29% vs 23%). However, none of seroreverted infants showed this antigen. HLA-B44 was more frequently detected in seroreverted children, and healthy controls than in seropositive children (50 and 32% vs 7%). Furthermore, children whom develop HIV infection showed a high rate of HLA-A24, A26 and DQw3 respect to healthy controls (43%, 25%, and 68% vs 12%, 8%, and 40%). Children whom seroreverted showed HLA-B18 and DR3 more frequently than seropositive (38% and 63% vs 18% and 19%). However HLA-DR4 was higher in both groups of children respect controls (39%-38% vs 15%). Remarkable differences on distribution of HLA frequencies are seen in children born from HIV-infected mothers, comparing those who becomes infected and those whom did not. Our results supports that HLA antigens would take a role in the susceptibility to vertical transmission of HIV-1 infection.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Adult
• Child
• Disease Transmission, Vertical
• HIV Infections
• HIV Seropositivity
• HLA Antigens
• HLA-A Antigens
• HLA-A24
• HLA-B Antigens
• HLA-B18
• HLA-B44
• Humans
• Infant
• Prevalence
• immunology
• transmission

Other ID:

• 93334575

UI: 102203949

From Meeting Abstracts