Simooya OO, Mwendapole RM, Sikateyo B, Mukunyandela M; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 384 (abstract no. 2123).
Tropical Diseases Research Centre, Box 71769, Ndola, Zambia
Severe falciparum malaria is typically a complication of malaria in young children and nonimmune visitors to endemic regions. In Zambia, about 6% of indigenous adults develop cerebral malaria (CM), the most fatal complication of malaria. In view of the high HIV-1 prevalence we decided to explore the possibility of an association between the two conditions. Of 39 serum specimens obtained from CM patients in 1982/3, 1 (3%) was HIV seropositive, whilst 3 (16%) of the 19 seen in 1986/7 were HIV-1 seropositive using the Wellcozyme immunoassay. No failure in the humoral response to Plasmodium falciparum malaria using an indirect fluorescent antibody technique (IFAT), was demonstrated in the CM patients. Amongst 42 patients with clinical AIDS, 35 (83%) were HIV-1 seropositive, of whom 4 (11%) had falciparum malaria as well even though they showed no signs of complicated malaria. Fourteen of the patients with serogically confirmed AIDS had an inadequate humoral response to malaria using the IFAT although this finding was insignificant. It was concluded that CM is not a complication of malaria in an HIV immunocompromised host and that AIDS patients infected with falciparum malaria may not necessarily develop severe malaria.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Adult
- Child
- Communicable Diseases
- Disease Progression
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Malaria
- Malaria, Cerebral
- Malaria, Falciparum
- Zambia
Other ID:
UI: 102197130
From Meeting Abstracts