Albert SM, Weber C, Todak G, Polanco C, Clouse R, Rabkin J, McElhiney M, Stern Y, Marder K.
J Neurovirol. 1998 Jun 3-6; 4: 338.
Columbia University, New York, NY.
Background: Neuropsychological assessment often reveals mild deficits in HIV, but it is unclear if such deficits do in fact compromise functional competencies, such as the ability to adhere to the complex medication regimens associated with HIV care. Object: To examine the relationship between neuropsychological status (NP), observed performance on a medication management test (MMT), and antiviral medication adherence as elicited in a 3-day recall measure. Methods: 57 HIV+ patients taking antivirals were assessed. NP performance was summarized according to age- and education-based norms. Adherence was summarized as number of errors in dosages, number of doses, and dosage intervals. Results: Poorer performance on the MMT was associated with scores < -1 SD below norms in tests of memory (RAVLT), executive function (Odd Man Out), and psychomotor skill (Grooved Pegboard). Half the sample made > 1 error, as reported in the recall measure. Number of errors was related to both NP and MMT performance, but NP domains were better predictors of adherence. Conclusion: Deficits identified in NP assessment and captured in an observed performance test predict adherence to HIV medication regimens.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Antiviral Agents
- Aptitude
- HIV Infections
- HIV Seropositivity
- Humans
- Male
- Mental Recall
- Neuropsychological Tests
- Neurosciences
- Research Design
- education
Other ID:
UI: 102237358
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