FIORITO SM, GALARZA PG, SPARO M, PAGANO IE, OVIEDO C; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 656 (abstract no. 303).
STD Natl. Reference Ctr. INEI, Buenos Aires, ARGENTINA
BACKGROUND: Primary meningococcal conjunctivitis is assumed to be due to the direct inoculation of Neisseria meningitidis (NM) into the conjunctiva from an exogenous source. No report of neonatal conjunctivitis infection acquired at delivery from a mother's endocervical infection, was published in the literature reviewed.METHODS: Patients: newborn 2 days old, with unilateral acute purulent conjunctivitis; his mother, with an endocervical infection (in both cases the direct stain showed Gram negative diplococcus); her partner, asyntomatic, but with meningococcal oropharyngeal colonization. The strains were isolated in Thayer Martin, incubated in 5% CO[2] at 361/2 C. NM was identified by oxidase test and acid production from glucose and maltose. Strains were characterized by serological grouping (agglutination), typing and subtyping (ELISA), and antimicrobial susceptibility testing (MIC). Molecular analysis included: plasmid profile and pulsed field gel electrophoresis (PFGE) with NheI and SfiI endonuclease digestion.RESULTS: The three strains showed the same antigenic formula C NT:P1.NT and exhibited identical NheI / SfiI PFGE patterns. No plasmid was observed in electrophoresis gel. Strains were susceptible to penicillin, tetracycline, ceftriaxone and ciprofloxacin.CONCLUSIONS: The identical phenotypic and genomic analysis of the strains evidence: a) NM vertical transmission at delivery from an endocervical mother's infection to her baby and b) cross transmission between sexual partners, since orogenital practice is common. The 3 NM isolates had the same serotype as the strain causing menigococcal disease in Tandil city during this year.
Publication Types:
Keywords:
- Communicable Diseases
- Conjunctivitis, Bacterial
- Delivery, Obstetric
- Disease Transmission, Vertical
- Electrophoresis, Gel, Pulsed-Field
- Female
- Humans
- Infant
- Infant, Newborn
- Meningococcal Infections
- Microbial Sensitivity Tests
- Neisseria meningitidis
- Ophthalmia Neonatorum
- Oropharynx
- Penicillins
- surgery
- transmission
Other ID:
UI: 102246277
From Meeting Abstracts