Cuff SM, Ruby J; Australasian Society for HIV Medicine. Conference.

Annu Conf Australas Soc HIV Med. 1996 Nov 14-17; 8: 131 (poster no. 163).

Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Acton.

In HIV, as in all viral infection, apoptosis is an important factor in both anti-viral defences and viral pathogenesis. Its regulation by the immune system is achieved using unique combinations of cytokines and cell surface molecules to instruct the infected cell and cells in the vicinity as to how to respond to the infection. This work in progress focuses on the importance of various cytokines in apoptosis in vivo in response to a viral infection. We have infected susceptible and resistant mouse strains with virulent virus (ectromelia virus, Moscow strain) and an attenuated strain (ectromelia virus, p28-) and compared the levels of apoptosis at the peak of infection. In addition we have infected mice lacking the receptors for cytokines previously shown to be pivotal in the immune response and compared the levels of apoptosis in response to infection by the virulent vs the attenuated viruses. These results show clear differences in the apoptotic profiles of susceptible and resistant mice, a trend which is carried over into the susceptibility and apoptotic profiles of the cytokine knockouts.

Publication Types:

• Meeting Abstracts

Keywords:

• Animals
• Apoptosis
• Cytokines
• Disease Susceptibility
• Ectromelia virus
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Mice, Inbred Strains
• Moscow
• Virus Diseases

Other ID:

• 97153745

UI: 102222000

From Meeting Abstracts