Seibel N, Desi M, Silvestre D, Korezlioglu J, Linard F; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 429 (abstract no. PO-B16-1762).
CRNN, Hopital de Bicetre, Paris.
OBJECTIVE. To demonstrate the importance of using follow-up trials and taking anxio-depressive status into account while interpreting cognitive impairment in HIV-infected subjects. SUBJECTS. 18 mostly homosexual HIV carriers belonging to CDC groups II (4), III or IV C2 (7) and IV (7), chosen within a cohort of 60, having been assessed 3 times, with no focal or identified brain disease at entry. METHODS. 1) psychiatric interview based on DSM III-R criteria, clinical scales (Spielberger's STAXI and the MADRS) and cognitive questionnaires, 2) neuropsychological evaluation including 16 subtests screening attention, memory, visuo-spatial function, motor dexterity, psychomotor speed, and language, 3) repeated assessments within a period ranging from 6 to 21 months. RESULTS. At entry cognitive status was impaired for 13 subjects (2II, 5III or IVC2, 6IV). Disorders had disappeared for 6 subjects (2II, 2IVC2 and 2IV) at following assessments allowing us to conclude on a psychogenic origin. For 6 subjects (3III, 3IV), cognitive status had either remained constant or had worsened within 7 to 17 months, whereas psychiatric symptoms had decreased, implying HIV encephalopathy. For the remaining subject an anxio-depressive state was associated to cognitive impairment which remained constant despite the regression of psychiatric symptoms within 6 months; we again concluded on HIV encephalopathy. CONCLUSION. Follow-up trials including 3 neuropsychological and psychiatric assessments and neuroimagery, if necessary, were required to ascertain the causes of cognitive impairment consequently attributed to anxio-depressive symptoms or HIV encephalopathy in 13 subjects.
Publication Types:
Keywords:
- AIDS Dementia Complex
- Acquired Immunodeficiency Syndrome
- Depression
- HIV Infections
- HIV Seropositivity
- Homosexuality
- Mental Disorders
Other ID:
UI: 102204719
From Meeting Abstracts