Shor-Posner G, Blaney N, Feaster D, Manteroatienza E, Beach RS, Sauberlich H, Goodkin K, Eisdorfer C, Baum MK; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: B209 (abstract no. PoB 3711).
Biopsychosocial Center for AIDS, University of Miami School of Medicine, Florida 33136.
OBJECTIVE: Serotonergic abnormalities have been associated with depressive and anxiety disorders. As patients with AIDS appear to exhibit disturbances in the various serotonin/tryptophan pathways, which may involve pyridoxal phosphate (vitamin B6)-dependent reactions, this study was conducted to determine the association between vitamin B6 status and mood states in early HIV-1 infected individuals. METHODS: Subjects were 108 HIV-1 seropositive, homosexual males between the ages of 20-55 years. The majority of men were asymptomatic (n = 88, CDC stage II, III), with a smaller proportion in the early symptomatic stage (n = 20, CDC Stage IVa, C-2). Vitamin B6 status was determined by erythrocyte transaminase assays. The Profile of Mood States (POMS) and Millon Clinical Multiaxial Inventory (MCMI II) scale were administered to all subjects. RESULTS: A large proportion (30%) of the HIV-1 infected men exhibited inadequate vitamin B6 status (activity coefficient greater than 1.85), which was significantly (p less than 0.05) associated with tension/anxiety (POMS) and bipolar manic behavior (MCMI scale). In addition, subjects with inadequate vitamin B6 status, who normalized, demonstrated a significant decrease in the POMS scale of depression (p less than 0.02). CONCLUSION: As vitamin B6 inadequacy is frequently observed in HIV-1 infection, and vitamin B6 is directly involved in the metabolism and synthesis of neurotransmitters, the altered mood states observed in HIV-1 infected individuals with vitamin B6 inadequacy may clinically reflect disturbances of serotonin/tryptophan pathways that have been demonstrated in AIDS.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Affect
- Anxiety
- Communicable Diseases
- Depression
- Depressive Disorder
- HIV Infections
- HIV-1
- Homosexuality, Male
- Humans
- Male
- Mental Disorders
- Personality Disorders
- Pyridoxal Phosphate
- Vitamin B 6
- Vitamin B 6 Deficiency
Other ID:
UI: 102199150
From Meeting Abstracts