BIEDENBACH D, STEPHEN J, JONES RN; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. C2-295.
The JONES Group, N Liberty, IA
BACKGROUND: To determine the variation of emerging resistance (R) among b HS, SENTRY sites sent community-acquired isolates for testing against numerous antimicrobials. Strains included S. pyogenes (SGA) from patients with clinical pharyngitis as well as serogroups (SG) B, C, F and G from a variety of infections. METHODS: The collection included 985 isolates from EU dominated by SGA (703) > SGB (150) > SGG (66) > SGC (41) > SGF (8); and 815 NA isolates SGA (397) > SGB (318) > SGG (45) > SGC (19) > SGF (8). Sites of infection were throat, lower respiratory, wound, urine, blood and CSF. b -haemolysis was confirmed on subculture, and bacitracin-susceptibility (SGA) and CAMP factor tests (SGB) were performed. Isolates were tested by NCCLS microdilution methods in Mueller-Hinton broth supplemented with 3 - 5% lysed horse blood. Susceptibility (S) to beta-lactams, levofloxacin (LEVO), erythromycin (ER), quin/dalfo (Q/D), linezolid (LZD), chloramphenicol (CH), vancomycin (VAN) and tetracycline (TET) was monitored. RESULTS: All b HS from NA and EU were S to penicillin (PEN), ceftriaxone, cefepime, LZD and VAN. PEN potency was greater (MIC[90] in microg/ml) against SGA (</= 0.015) and SGG (</= 0.015-0.03) compared to the other SGs (0.03 - 0.12). ER-R % was EU > NA overall, for SGA (15.0 > 9.1); SGC (7.3 > 5.3); SGF (12.5 > 0.0) and SGG (21.2 > 15.5). In contrast, ER-R SGB was much higher in NA (30.8%) than EU (12.7%). M-phenotypes (mef A) dominated SGA (91.2 - 95.2%), SGC (67.1 - 100.0%) and SGF (100.0%) in both NA and EU. M-phenotypes in NA/EU for SGB (61.4/15.7%) and SGG (85.9/32.3%) were significantly different. TET-R was common among SGB and SGG (MIC[50], 8 - > 8 microg/ml) compared to other SGs (MIC[50/90], </= 4/> 8 microg/ml). CH-R was found only in EU (2.7%), only 1 isolate from EU had a Q/D-non-S MIC and 1 isolate was R to LEVO in NA. CONCLUSIONS: beta-lactams, LZD, VAN and Q/D were very active against b HS strains from NA and EU. Macrolide-R mechanisms vary greatly between NA and EU, and require continued surveillance efforts to guide alternative treatments.
Publication Types:
Keywords:
- Acetamides
- Anti-Bacterial Agents
- Anti-Infective Agents
- Europe
- Humans
- Microbial Sensitivity Tests
- North America
- Ofloxacin
- Oxazolidinones
- Penicillins
- Streptococcus
- beta-Lactams
- linezolid
Other ID:
UI: 102267298
From Meeting Abstracts