TUOHY M, PROCOP GW, WASHINGTON J; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 271 (abstract no. 2277).
The Cleveland Clin. Fndn., Cleveland, OH.
Prior studies of the susceptibility of Abiotrophia spp. have shown them to be highly susceptible to most antimicrobial agents. With the increasing penicillin resistance of viridans streptococci, it seemed timely to reexamine the susceptibility of Abiotrophia. A total of 27 A. adjacens and 13 A. defectiva isolates were tested in pyridoxal supplemented Mueller-Hinton broth with lysed horse blood. Applying the NCCLS interpretative criteria appropriate to viridans streptococci, the susceptibilities of A. adjacens and A. defectiva were, respectively: penicillin (=0.12 microg/ml), 61% and 13%; amoxicillin (>= 0.5 microg/ml), 88% and 92%; cefazolin (>=0.5 microg/ml), 58% and 8%; ceftriaxone (>=0.5 microg/ml), 69% and 85%; and 100% for both species against meropenem (>=0.12 microg/ml), clindamycin (>=0.25 microg/ml), rifampin (>=1 microg/ml), levofloxacin (>=2 microg/ml), ofloxacin (>=2 microg/ml), quinupristin/ dalfopristin (>=2 microg/ml), and vancomycin (>=1 microg/ml). No high level resistance to gentamicin was observed. Although therapy of endocarditis due to Abiotrophia spp. is empirical and usually consists of the combination of penicillin and gentamicin, this combination was based on the assumption of the susceptibility of the organism to penicillin which is no longer the case. Moreover, there was a striking species-specific difference in penicillin and cefazolin susceptibility. The clinical implications of these findings remains uncertain.>
Publication Types:
Keywords:
- Amoxicillin
- Cefazolin
- Ceftriaxone
- Clindamycin
- Gentamicins
- Ofloxacin
- Penicillin Resistance
- Penicillins
- Streptococcus
- Thienamycins
- Vancomycin
- Virginiamycin
- Viridans Streptococci
- dalfopristin
- meropenem
- quinupristin
Other ID:
UI: 102245296
From Meeting Abstracts