WATTS JL, ROSSBACH S; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 219 (abstract no. 909).

Pharmacia & Upjohn, Kalamazoo, MI

Coryneform bacteria are frequently isolated from infected mammary glands of dairy cows and these infections are associated with economic losses. Antimicrobial therapy is an essential tool for eliminating these organisms from the mammary glands of infected animals. The minimum inhibitory concentration (MIC) of 47 lipid-requiring coryneform bacteria (25 Corynebacterium bovis and 22 Corynebacterium jeikeium) isolated from infected bovine mammary glands was determined to the following antimicrobial agents: ampicillin, oxacillin, cephalothin, ceftiofur, a combination of penicillin and novobiocin, erythromycin, clindamycin, and pirlimycin. All of these agents are available as mastitis therapy products except clindamycin and ceftiofur. Clindamycin was included as the class representative for clindamycin and lincomycin and ceftiofur was included to represent the third generation cephalosporins. MIC determinations were performed using a microdilution method according to NCCLS guidelines except that the Mueller-Hinton broth was supplemented with 1% Tween 80. Quality control organisms were included in each day of testing. The MIC[90] values for the 25 C. bovis strains tested with ampicillin, oxacillin, cephalothin, ceftiofur, a combination of penicillin and novobiocin, erythromycin, clindamycin, and pirlimycin were 0.25, 4.0, 0.5, 0.25, 0.25,

Publication Types:

• Meeting Abstracts

Keywords:

• Ampicillin
• Animals
• Anti-Infective Agents
• Bacteria
• Cattle
• Cephalosporins
• Cephalothin
• Clindamycin
• Erythromycin
• Female
• Microbial Sensitivity Tests
• Novobiocin
• Oxacillin
• Penicillins
• ceftiofur
• pirlimycin

Other ID:

• GWAIDS0007639

UI: 102245135

From Meeting Abstracts