LOEB MB; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 527.

McMaster Univ., Hamilton, ON, Canada

Antibiotics are used extensively in long-term care facilities where usage rates rival those in acute care hospitals. The intense use of antibiotics in this population has lead to increasing concern about the potential for the development of antibiotic resistance. Numerous reports which describe the detection of antibiotic resistant organisms in this population exist. Most of this data is derived from outbreak investigations or surveillance studies, and includes detection of Enterobacteraciae resistant to aminoglycosides or trimethoprim-sulfamethoxazole, Enterococci resistant to aminoglycosides, Enterobacteraciae resistant to third generation cephalosporins or quinolones, methicillin resistant Staphylococcus aureus, and vancomycin resistant Enterococci. Relatively little is known however about the quantitative relationship between antibiotic use and antibiotic resistance in institutionalized older adults. The extensive use of antibiotics in these facilities along with the relative ease of long-term follow up, offers a unique opportunity to address this issue. Data from a recently completed ecologic study conducted in 50 Canadian and American nursing homes will be presented. Logistic regression models demonstrating the relationship between the utilization of specific antibiotics and corresponding patterns of bacterial resistance will be presented. Methodological issues including the optimal unit of analysis (individual versus aggregate) and the potential for cross-level bias will be reviewed.

Publication Types:

• Meeting Abstracts

Keywords:

• Adult
• Aminoglycosides
• Anti-Bacterial Agents
• Canada
• Drug Resistance
• Enterococcus
• Hospitals
• Humans
• Long-Term Care
• Nursing Homes
• Staphylococcus aureus
• Streptococcus pneumoniae
• Trimethoprim-Sulfamethoxazole Combination
• utilization

Other ID:

• GWAIDS0010012

UI: 102247510

From Meeting Abstracts