Lopita MI, Temmerman M, Sinei SK, Plummer F, Wamola I, Piot P; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 288 (abstract no. Th.C.653).
University of Nairobi, Kenya
OBJECTIVE: To determine whether HIV infection and other sexually transmitted diseases (STD) are risk factors for spontaneous first trimester abortion. METHODS: A case-control study was carried out at the Dept. of OBS/GYNE, Kenyatta National Hospital, Nairobi, Kenya. 135 pregnant mothers presenting with signs and symptoms of a first trimester abortion were enrolled as cases. Excluded from the analysis were women whose abortion was probably induced (based on the history and/or physical examination). 135 controls were selected at random from mothers at the antenatal clinic, with a gestation beyond 20 weeks. Data collection included sociodemographic features, sexual and medical history, clinical signs and symptoms, serology for HIV and syphilis, and microbiology for N. gonorrhoeae, C. trachomatis, S. agalactiae, M. hominis, U. urealyticum, T. vaginalis and bacterial vaginosis. RESULTS: 20 out of 135 women were excluded based on the suspicion of the abortion being induced. Although the HIV seroprevalence was higher in the abortion group as compared to the controls (10.4% versus 5.2%, p = 0.12; p = 0.12) the difference did not reach statistical significance. Spontaneous first trimester abortion was associated with positive syphilis serology (13.7% of the cases versus 1.3% of the controls, p = .009, OR = 12.2, 95% CI 1.5-79.5) and with maternal colonisation with S. agalactiae (16.8% vs 3.8%, p = .001, OR = 5.1, 95% CI 1.7-16.4). No association was found between other STD and spontaneous first trimester abortion. CONCLUSION: These preliminary results suggest that maternal HIV infection is not significantly associated with spontaneous first trimester abortion in the population studied.
Publication Types:
Keywords:
- Abortion, Spontaneous
- Acquired Immunodeficiency Syndrome
- Ambulatory Care Facilities
- Case-Control Studies
- Female
- Gonorrhea
- HIV Infections
- HIV Seropositivity
- HIV Seroprevalence
- Humans
- Kenya
- Pregnancy
- Pregnancy Complications
- Pregnancy Outcome
- Pregnancy Trimester, First
- Risk Factors
- Sexually Transmitted Diseases
- Syphilis
- Vaginosis, Bacterial
Other ID:
UI: 102182250
From Meeting Abstracts