Servais J, Hemmer R, Staub T, Fournier P, Arendt V, Schneider F, Schmit JC; International Conference on AIDS.

Int Conf AIDS. 1998; 12: 548 (abstract no. 32139).

Laboratoire de Retrovirologie, CRP-Sante, Luxembourg City.

OBJECTIVES: 1) To determine the correlations between hematological parameters and plasma viral load in treatment-naive HIV-1-seropositive persons. 2) To investigate the effect of HAART on hematological parameters. DESIGN: Retrospective study. METHODS: We compared the HIV-1 plasma viral load (Quantiplex 2.0., Chiron) to hematological parameters in 106 patients without antiretroviral treatment, and additionally we followed hematological parameters in 36 patients every three months for one year after initiation of HAART. RESULTS: In treatment-naive patients a significant inverse correlation was found between viral load and hemoglobin (Hb) (correlation coefficient r = -0.23; p = 0.012), granulocyte count (r = -0.36; p < 0.001), CD4 cell count (r = -0.38; p < 0.001), and platelet (PLT) count (r = -0.20; p = 0.029). In the HAART group, viral load decreased significantly (average: -1.14 log RNA copies/mL; p = < 0.001) over the 12 months of treatment. During the same period, a statistically significant increase in Hb (+0.4 g/dL; p < 0.001), granulocyte count (+308/microL; p = 0.045) and CD4 cell count (+64/microL; p = 0.012) was observed. The average PLT count increased (+26,000/microL) non-significantly (p = 0.45). The proportion of patients with hematological values below the limit of normal declined under HAART from baseline to month 12 (Hb < 14 g/dL: 55% to 36%; WBC < 4,800/microL: 64% to 47%; PLT < 130,000/microL: 19% to 11% and granulocytes < 1,900/microL: 58% to 36%). CONCLUSIONS: The main hematological parameters correlate with the plasma viral load in HIV infected treatment-naive patients. HAART tends to correct, at least partially, existing hematological abnormalities. These findings support the hypothesis that hematological disorders in HIV infection are virus-mediated.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Antiretroviral Therapy, Highly Active
• CD4 Lymphocyte Count
• HIV Infections
• HIV Seropositivity
• HIV-1
• Hematologic Diseases
• Humans
• Retrospective Studies
• Viral Load
• virology

Other ID:

• 98396111

UI: 102229654

From Meeting Abstracts