Falutz J, Paltiel O, DiGirolamo A, Tsoukas CM; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 258 (abstract no. M.B.2306).
McGill AIDS Centre, Montreal, Canada
OBJECTIVE: To assess the prevalence of low vitamin B12 levels, and associated hematologic abnormalities, in patients with asymptomatic HIV infection and AIDS. METHODS: Serum B12 was measured by radioimmunoassay in 78 pts not on AZT and in 84 pts who received AZT for at least 3 months. Pts had variable HIV-related manifestations, and had CD4+ T cells counts ranging from normal to severely depleted. Complete blood counts and T lymphocyte determinations were done within 2 months of B12 assays. RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. No differences existed in total WBC, granulocytes, Hgb, or MCV between pts with low vs normal B12, after controlling for AZT use, and CD4+ count. CONCLUSIONS: The high observed frequency of subnormal B12 was not associated with B12 related hematologic abnormalities. Low B12, unassociated with AZT use, was frequent in pts. with severe CD4 cell depletion. In pts. with mild to moderate CD4 loss, there was a positive association between AZT use and low B12. The significance of low B12 levels, and its relationship to the use of AZT, remains to be determined.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antigens, CD4
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- HIV Infections
- HIV Seropositivity
- Hematologic Tests
- Humans
- Prevalence
- Schilling Test
- Zidovudine
- immunology
Other ID:
UI: 102183226
From Meeting Abstracts