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 Thursday, September 11, 2008 Volume 21   Number 11
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
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Obesity and Genetics
Obesity is a major health hazard that has reached epidemic proportions in populations whose environments offer an abundance of calorie-rich foods and few opportunities for physical activity. Though population genetic changes are too slow to be blamed for the increase in obesity, genes play a role in the development of obesity. Read more


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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
blue dotBack Issues

 Upcoming Events
Genomics Announcements

CDC logo
CDC's National Office of Public Health Genomics seeks a new behavioral health scientist. For more information about the position, visit the U.S. Department of Health and Human Services non-gov warning icon web site and enter the vacancy number (HHS-CDC-T2-2008-0766 — for current employees or HHS-CDC-D2-2008-0312 — for non-federal applicants). The deadline to apply is September 23, 2008.

New version of HuGE Navigator non-gov warning icon (1.3) launched, with new applications and features:  1) Variant Name Mapper, non-gov warning icon for mapping common genetic variant names to their corresponding rs numbers;  2) a new category for indexing research articles on mitochondrial genomics (users can view this new category in HuGE Literature Finder and HuGE Watch); 3) capacity for downloading query results from Phenopedia non-gov warning icon and Genopedia. non-gov warning icon .


The National Institutes of Health announces two new funding opportunities for genomics translation research:

Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.


Genetic region linked to a 5 times higher lung cancer risk, non-gov warning icon Medical News Today, September 10

Genome lights the way to cancer 'milestone', non-gov warning icon Baltimore Sun, September 5

Early stage colon cancer characterized by inactivation of gatekeeper gene, Singapore... , non-gov warning icon Medical News Today, September 10

The cancer genome atlas reports first results of comprehensive study of brain tumors, non-gov warning icon NIH News, September 4

Lung cancer risk models created for specific populations, prediction refined,non-gov warning icon Medical News Today, September 8

Gene trawl shows curing cancer harder than thought, non-gov warning icon Reuters Health, September 4

Study: Family history may leave African-Americans unscreened, non-gov warning icon The JHU Gazette, September 8


Ethical, Legal and Social Issues (ELSI)

Malaysia: Genetic fingerprinting bill under flak, non-gov warning icon IPS, September 10

Guide launched to prepare Americans for newly passed health legislation; Coalition for genetic..., non-gov warning icon AScibe, September 9


Family History

Genetic Testing

Healthy you: Learn the importance of knowing your family health history, non-gov warning icon Eurweb, September 9

Personal DNA scanning service 23andMe drops price to $399, non-gov warning icon News-Medical.Net, September 10



Physical activity can blunt the effect of obesity genes, non-gov warning icon News-Medical.Net, September 9


Other News

Genetic mutation prevents fetal malaria transmission, study says, non-gov warning icon News-Medical.Net, September 11

Variety in the splice of life: Chromosome breaks are surprisingly complex, non-gov warning icon Medical News Today, September 9

Symposium: How do race, genetics and health-care disparities affect spread of HIV, non-gov warning icon Medical News Today, September 11 

Genetic screening could help thousands, non-gov warning icon Wales Online, September 8

Virus is passed from parent to child in the DNA, non-gov warning icon Reuters Health, September 4

Lab to detect genetic defects in newborns, non-gov warning icon The Times of India, September 8

First Of 100 Arab Human Genomes sequenced by Saudi Biosciences, Beijing Genomics Institute..., non-gov warning icon Medical News Today, September 10

Valley family battling rare genetic disease, non-gov warning icon WAFF 48 News, September 8

Genetic variants associated with vitamin B12, non-gov warning icon Science Daily, September 9

Framing the concept of a gene, non-gov warning icon News-Medical.Net, September 4

Safety study indicates gene therapy for blindness improves vision, non-gov warning icon Medical News Today, September 9

Genomics in Scientific Literature
Featured Item

Evaluation of the Potential Excess of Statistically Significant Findings in Published Genetic Association Studies: Application to Alzheimer's Disease
Kavvoura FK, et al.
Am J Epidemiol 2008 Sep

 General Articles

Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays
Homer N, et al.
PLoS Genet. 2008 Aug 29;4(8):e1000167

Protecting Aggregate Genomic Data
Zerhouni EA & Nabel EG
Science 2008 Sep

An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment
Ekhart C, et al.
Cancer Treat Rev 2008 Sep

A joint association test for multiple SNPs in genetic case-control studies
Wang T, et al.
Genet Epidemiol 2008 Sep

The FBN2 gene: new mutations, locus-specific database (Universal Mutation Database FBN2), and genotype-phenotype correlations
Frederic MY, et al.
Hum Mutat 2008 Sep

Stratification for smoking in case-cohort studies of genetic polymorphisms and lung cancer
Sorensen M, et al.
Lung Cancer 2008 Sep

Germline Polymorphisms as Modulators of Cancer Phenotypes
Tan P
BMC Med 2008 Sep;6(1):27

Genomic Variation in Myeloma: Design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression free survival
Van Ness B, et al.
BMC Med 2008 Sep;6(1):26

Ethics of Future Disclosure of Individual Risk Information in a Genetic Cohort Study: A Survey of Donor Preferences
Matsui K, et al.
J Epidemiol 2008 Sep

The Stigmatising Implications of Presenting Schizophrenia as a Genetic Disease
Bennett L, et al.
J Genet Couns 2008 Sep

Can genes for mammographic density inform cancer aetiology?
Kelemen LE, et al.
Nat Rev Cancer 2008 Sep

Genes in asthma: new genes and new ways
Moffatt MF
Curr Opin Allergy Clin Immunol 2008 Oct;8(5):411-7

Genomics: risk and outcomes in cardiac surgery
Perry TE, et al.
Anesthesiol Clin 2008 Sep;26(3):399-417

 Family History

Genetics of headache in children: where are we headed?
Hershey AD
Curr Pain Headache Rep 2008 Oct;12(5):367-72

Heritability of the severity of diabetic retinopathy: the FIND-Eye study
Arar NH, et al.
Invest Ophthalmol Vis Sci 2008 Sep;49(9):3839-45

Psychiatric disorder in young adults born very preterm: Role of family history
Walshe M, et al.
Eur Psychiatry 2008 Sep


 Genetic Testing

Attitudes toward genetic testing and personalised nutrition in a representative sample of European consumers
Stewart-Knox BJ, et al.
Br J Nutr 2008 Sep:1-8


 Genome Wide

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Blondal T, Jakobsdottir M,
Stacey SN, Kos
Brooks J
Urol Oncol 2008 Sep-2008 Oct;26(5):569-70

Multiple newly identified loci associated with prostate cancer susceptibility Eeles RA, Kote-Jarai Z, Giles GG, Olama AA, Guy M, Jugurnauth SK, Mulholland S, Leongamornlert DA, Edwards SM, Morrison J, Field HI, Southey MC, Severi G, Donovan JL, Hamdy
Brooks J
Urol Oncol 2008 Sep-2008 Oct;26(5):570

Common variants of FUT2 are associated with plasma vitamin B(12) levels
Hazra A, et al.
Nat Genet 2008 Sep

Identification of PLCL1 Gene for Hip Bone Size Variation in Females in a Genome-Wide Association Study
Liu YZ, et al.
PLoS ONE 2008;3(9):e3160

HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending September 10, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page


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Page last updated: September 11, 2008
Content Source: National Office of Public Health Genomics