Staff information

Karin Rodland

Biological Sciences Division
Laboratory Fellow
Pacific Northwest National Laboratory
PO Box 999
MSIN: P7-54
Richland, WA 99352
E-mail:

Biography

Dr. Rodland's research is focused on understanding the control of critical cellular decisions: to divide or remain quiescent; to differentiate or remain multipotent; to repair damage or die by apoptosis. Of particular interest to her is the difference in the signal transduction mechanisms regulating these processes in ovarian surface epithelial cells and in ovarian adenocarcinoma cells derived from the normal epithelial cells. Dr. Rodland was the among the first to demonstrate that variations in extracellular calcium concentration could be sensed by a variety of epithelial and mesenchymal cells through activation of the G-protein coupled calcium-sensing receptor, resulting in activation of the Ras-Raf-MEK-ERK signaling cascade. Dr. Rodland's current research focuses on understanding the signaling pathways that control critical cellular decisions involved in the process of malignant transformation. She is involved in applying proteomics capabilities developed at PNNL to identify biomarkers for early detection of breast and other cancers, and indeveloping new biomarker assays.

Prior to joining the Pacific Northwest National Laboratory, Dr. Rodland was an associate professor in the department of cell and developmental biology at Oregon Health Sciences University from 1985-2001. Dr. Rodland retains her status as member of the Oregon Cancer Institute and as a collaborating scientist at the Oregon Regional Primate Research Center.

Research Interests

Understanding the control of critical cellular decisions: to divide or remain quiescent; to differentiate or remain multipotent; to repair damage or die by apoptosis
Signal transduction mechanisms regulating these processes in ovarian surface epithelial cells and in ovarian adenocarcinoma cells derived from the normal epithelial cells
Signaling pathways that control critical cellular decisions involved in the process of malignant transformation
Applying proteomics capabilities developed at PNNL to identify biomarkers for early detection of breast and other cancers, and in developing new biomarker assays

Education and Credentials

Ph.D., Biology, Syracuse University
A.B., Biology/Education, Hood College

Affiliations and Professional Service

American Society for Cell Biology
American Society for Biochemistry and Molecular Biology
American Association for Cancer Research
American Association for the Advancement of Science
Editor of Cancer Biomarkers and Cancer Genomics and Proteomics

Awards and Recognitions

Member, Metabolic Pathology Study Section, National Institutes of Health, 1998�"2003
Teaching Excellence Award OHSU Basic Science Graduate Program, 1996-1997
Member, Program Project Parent Review Committee, 1995; 1999
Member, Ovarian Program Project Review, 1995-1998
Syracuse University Senate Research Award, 1974-1975
Syracuse University Fellow, 1973-1974
Summa cum laude, Hood College, 1970
Departmental Honors in Biology, Hood College, 1970
Senatorial Scholarship to Hood College, 1966-1970

PNNL Publications

2008

Seurynck-Servoss SL, CL Baird, KD Miller, NB Pefaur, RM Gonzalez, DO Apiyo, HE Engelmann, S Srinivastava, J Kagan, KD Rodland, and RC Zangar. 2008. "Immobilization strategies for single-chain antibody microarrays." Proteomics 8(11):2199-2210. doi:10.1002/pmic.200701036

2007

Seurynck-Servoss SL, CL Baird, KD Rodland, and RC Zangar. 2007. "Surface chemistries for antibody microarrays." Frontiers in Bioscience 12:3956-3964. doi:10.2741/2362
Seurynck-Servoss SL, AM White, CL Baird, KD Rodland, and RC Zangar. 2007. "Evaluation of Surface Chemistries for Antibody Microarrays." Analytical Biochemistry 371(1):105-115.

2006

Adkins JN, HM Mottaz, AD Norbeck, JK Gustin, J Rue, TRW Clauss, SO Purvine, KD Rodland, F Heffron, and RD Smith. 2006. "Analysis of the Salmonella typhimurium Proteome through Environmental Response toward Infectious Conditions." Molecular & Cellular Proteomics. MCP 5(8):1450-1461. doi:10.1074/mcp.M600139-MCP200
Shi L, JN Adkins, JR Coleman, AA Schepmoes, A Dohnalkova, HM Mottaz, AD Norbeck, SO Purvine, NP Manes, HS Smallwood, HH Wang, J Forbes, P Gros, S Uzzau, KD Rodland, F Heffron, RD Smith, and TC Squier. 2006. "Proteomic Analysis of Salmonella enterica Serovar Typhimurium Isolated from RAW 264.7 Macrophages: identification of a novel protein that contributes to the replication of serovar Typhimurium inside macrophages." Journal of Biological Chemistry 281:29131-29140. doi:10.1074/jbc.M604640200

2005

Adkins JN, ME Monroe, KJ Auberry, Y Shen, JM Jacobs, DG Camp, II, F Vitzthum, KD Rodland, RC Zangar, RD Smith, and JG Pounds. 2005. "A Proteomic Study of the HUPO Plasma Proteome Project's Pilot Samples using an Accurate Mass and Time Tag Strategy." Proteomics 5(13):3454-3466. doi:10.1002/pmic.200401333
Wright JW, RL Stouffer, and KD Rodland. 2005. "High-Dose Estrogen and Clinical Selective Estrogen Receptor Modulators Induce Growth Arrest, p21, and p53 in Primate Ovarian Surface Epithelial Cells." Journal of Clinical Endocrinology and Metabolism 90 (6):3688-3695.

2004

Rodland KD. 2004. "Mass Spectrometry and Biomarker Development." Disease Markers 20(3):129-130.
Varnum SM, DN Streblow, ME Monroe, P Smith, KJ Auberry, L Pasa-Tolic, D Wang, DG Camp, II, KD Rodland, HS Wiley, W Britt, T Shenk, RD Smith, and J Nelson. 2004. "Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome ." Journal of Virology 78(20):10960-10966.

2003

Springer DL, DL Auberry, M Ahram, JN Adkins, JM Feldhaus, JH Wahl, DM Wunsch, and KD Rodland. 2003. "Characterization of plasma membrane proteins from ovarian cancer cells using mass spectrometry ." Disease Markers 19(4-5):219-228.

2002

Buchanan MV, F Larimer, HS Wiley, SJ Kennel, TC Squier, JM Ramsey, KD Rodland, GB Hurst, RD Smith, Y Xu, DA Dixon, MJ Doktycz, SD Colson, R Gesteland, CS Giometti, ME Young, and RM Giddings. 2002. "Genomes to Life "Center for Molecular and Cellular Systems": A research program for identification and characterization of protein complexes." OMICS. A Journal of Integrative Biology 6(4):287-303.
Wright JW, S Toth-Fejel, RL Stouffer, and KD Rodland. 2002. "Proliferation of rhesus ovarian surface epithelial cells in culture: Lack of mitogenic response to steroid or gonadotropic hormones." Endocrinology 143(6):2198-2207.

2001

Springer DL, RC Zangar, KL Wahl, KK Wong, and KD Rodland. 2001. "Proteomic Analysis of Changes in Protein Tyrosine Phosphorylation in Transformed Cells after Treatment with a Novel Chemotherapeutic, Carboxyamidotriazole." Toxicological Sciences 60(1):139.