SYNTHESIS AND TESTING OF NONSTEROIDAL AND NONHORMONAL MALE CONTRACEPTIVE AGENTS Release Date: February 23, 2000 NOTICE: HD-00-003 RFP AVAILABLE: RFP-NICHD-CRHB-2000-3 National Institute of Child Health and Human Development The Contraception and Reproductive Health Branch, Center for Population Research, National Institute of Child Health and Human Development (NICHD), requires the synthesis and testing of non-steroidal and non-hormonal male contraceptive agents. The specific objectives of the project are the design, synthesis, and testing of non-steroidal and non-hormonal male contraceptive agents that inhibit testicular sperm development, post-testicular sperm maturation, and epididymal function. Such compounds should be devoid of (or have minimal) ancillary, central nervous system, cardiovascular, and other side effects. Organizations must have adequate facilities and capabilities to carry out the proposed synthetic chemical program. The Federal Government is prepared to test such compounds in several standard assays if the contractor is unable to perform such testing. Specifically excluded from this project are GnRH analogs; gossypol derivatives; steroidal agents; all alkylating agents including chlorohydrin, deoxychlorosugars, nitrogen mustards, ethyleneimines, and sulfonoxyalkanes; nonspecific antimetabolites; antimitotic agents; N-substituted diamines (such as Win. 13,099); nitroheterocyclic compounds, and cytotoxic agents. Proposals merely to collect compounds from various sources and/or to perform biological assays will not be considered. All responsible sources may submit proposals for consideration by the agency. It is anticipated that three cost- reimbursement, incrementally funded contracts will be awarded as a result of the RFP for a period of 36 months each, beginning September 29, 2000. This is not a Request for Pproposals (RFP). RFP-NICHD-CRHB-2000-03 will be issued on or about February 24, 2000. Proposals will be due approximately 90 days thereafter. Copies of the RFP may be obtained by sending a written request to the address listed under INQUIRIES below. Requests may also be made by FAX or E-mail. INQUIRIES Inquiries regarding this notice should reference RFP-NICHD-CRHB-2000-03, and should be directed to: Paul J. Duska Contracting Officer Contracts Management Branch National Institute of Child Health and Human Development 6100 Executive Blvd., Suite 7A07, MSC 7510 Bethesda, MD 20892-7510 Telephone: (301) 496-4611 Fax: (301) 402-3676 E-mail: pd28n@nih.gov
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