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Sexually Transmitted Diseases
Abbreviations on this page:

GISP = Gonococcal Isolate Surveillance Project

MIC = Minimum inhibitory concentrations

N. gonorrhoeae = Neisseria gonorrhoeae

NCCLS = National Committee for Clinical Laboratory Standards

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The Gonococcal Isolate Surveillance Project (GISP) was established in 1986 to monitor trends in antimicrobial susceptibilities of strains of N. gonorrhoeae in the United States in order to establish a rational basis for the selection of gonococcal therapies. GISP is a collaborative project between selected sexually transmitted diseases (STD) clinics, five regional laboratories, and the Centers for Disease Control and Prevention (CDC).

In GISP, N. gonorrhoeae isolates are collected from the first 25 men with urethral gonorrhea attending STD clinics each month in approximately 28 cities in the United States. At regional laboratories, the susceptibilities of these isolates to penicillin, tetracycline, spectinomycin, ciprofloxacin, ceftriaxone, cefixime, and azithromycin are determined by agar dilution. Minimum inhibitory concentrations (MICs) are measured, and values are interpreted according to criteria recommended by the National Committee for Clinical Laboratory Standards (NCCLS).


Annual Reports

Sentinel Sites and Regional Laboratories

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* indicates Regional Laboratories

Albuquerque, NM
*Atlanta, GA
Baltimore, MD
*Birmingham, AL
Chicago, IL
Cincinnati, OH
*Cleveland, OH
Dallas, TX
*Denver, CO
Detroit, MI
Greensboro, NC
Honolulu, HI
Las Vegas, NV
Long Beach, CA
Los Angeles, CA
Miami, FL
Minneapolis, MN
New Orleans, LA
New York, NY
Orange County, CA
Oklahoma City, OK
Philadelphia, PA
Phoenix, AZ
Portland, OR
San Diego, CA
San Francisco, CA
*Seattle, WA
Tripler Army Medical center, Honolulu, HI

Forms & Coding Guide

Page last modified: June 4, 2008
Page last reviewed: June 4, 2008

Content Source: Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention