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Theoretical issues in the synthesis of HIV prevention research.

Journal of Acquired Immune Deficiency Syndromes 2002;30(Suppl 1):S8-S14.

Hedges LV, Johnson WD, Semaan S, Sogolow E.

Abstract
The evidence base for science and health policy consists of many independent research studies. Combining evidence from multiple studies that differ in important ways presents challenges that have been addressed in other areas of scientific research and are now beginning to be addressed in HIV prevention research. Syntheses can enhance statistical power and produce summary evidence that is more generalizable than individual primary research.