Biography

Hormuzd A. Katki received a B.S. in Math from the University of Chicago then an M.S. in Statistics from Carnegie-Mellon University. He joined NCI in 1999 as a Staff Scientist. He received a Ph.D in Biostatistics from Johns Hopkins University in 2006 and received the Margaret Merrell Award for research by a Biostatistics doctoral student.

Research Interests

• Clinical applications of genetics, especially extending statistical models that estimate the probability of having mutations that cause disease based on family history of disease
• Methodology and software for estimating absolute and attributable risks from studies nested within cohorts, such as case-cohort, two-stage, two-phase, and case-control-within-cohort designs. These are cohort studies but have missing co-variate information. My R package Nested Cohort analyzes this kind of data.
• Population genetics with survey data
• Assessing uncertainty in growth curve estimates

Keywords

Mendelian mutation prediction models, BRCAPRO, BayesMendel, two-stage studies, NestedCohort, NHANES, tolerance intervals

Selected Publications

• Katki HA (2007), Incorporating Medical Interventions into Carrier Probability Estimation for Genetic Counseling. BMC Medical Genetics, 8:13 (22Mar2007).
• Mark SD and Katki HA (2006), Specifying and Implementing Nonparametric and Semiparametric Survival Estimators in Two-Stage (sampled) Cohort Studies with Missing Case Data. Journal of the American Statistical Association, 101(474):460-471.
• Katki HA (2006), Effect of Misreported Family History on Mendelian Mutation Prediction Models, Biometrics, DOI:10.1111/j.1541-0420.2005.00488.x.
• Katki HA, Engels EA, and Rosenberg PS (2005), Assessing Uncertainty in Reference Intervals via Tolerance Intervals: Application to a Mixed Model Describing HIV Infection. Statistics in Medicine, 24(20):3185-3198.
• Chen S, Wang W, Broman KW, Katki HA, and Parmigiani G. (2004), BayesMendel: an R environment for Mendelian Risk Prediction. Statistical Applications in Genetics and Molecular Biology, Vol. 3: No. 1, Article 21.
• Rosenberg PS, Katki H, Swanson CA, Brown LM, Wacholder S, Hoover RN (2003), Quantifying epidemiologic risk factors using non-parametric regression: model selection remains the greatest challenge. Statistics in Medicine, 22(21):3369-3381.
• Engels EA, Katki HA, Nielsen NM, Winther JF, Hjalgrim H, Gjerris F, Rosenberg PS, Frisch M (2003), Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40. Journal of the National Cancer Institute, 95:532-539.
• Gail, M.H. Katki, H.A. (2002), Re: All-cause mortality in randomized trials of cancer screening, Journal of the National Cancer Institute, Vol. 94, No. 11, 862-866.
• Mark, S.D., Katki, H. (2001), Influence Function Based Variance Estimation and Missing Data Issues in Case-Cohort Studies, Lifetime Data Analysis, Vol. 7, 331-344.
• Engels, E.A., Rosenberg, P.S., Katki, H., Goedert, J.J., Biggar, R.J. (2001), Trends in Human Immunodeficiency Virus Type 1 (HIV) Viral Load Levels among HIV-infected Children with Hemophilia, Journal of Infectious Diseases, Vol 184 No. 3, 364-368.
• Mark, S.D., Qiao, Y.-L. Dawsey, S.M., Wu, Y.-P., Katki, H., Gunter, E., Fraumeni, Jr., J.F., Blot, W.J., Dong, Z.-W., Taylor, P.R. (2000) Prospective Study of Serum Selenium Levels and Incident Esophageal and Gastric Cancers, Journal of the National Cancer Institute, Vol. 92 No. 21, 1753-1763.
• Katki, H., Weiss, G.H., Keifer, J.E., Taitelbaum, H., Spencer, R.G.S (1996), "Optimization of Magnetization Transfer Experiments to Measure First-Order Rate Constants and Spin-Lattice Relaxation Times," NMR in Biomedicine, 9, 135-139.

Collaborators

DCEG Collaborators

• Andrew Bergen, Ph.D; Eric Engels, M.D., M.P.H; Mitchell Gail, M.D, Ph.D; Mark Greene, M.D; Barry Graubard, Ph.D; Philip Rosenberg, Ph.D; Sholom Wacholder, Ph.D; Regina Ziegler, Ph.D

Other NCI Collaborators

• None

Other Scientific Collaborators

• Sining Chen, Ph.D, Johns Hopkins University, Baltimore, MD
• Steven Mark, M.D., Sc.D, University of Colorado Health Sciences Center, Denver, CO
• Giovanni Parmigiani, Ph.D, Johns Hopkins University, Baltimore, MD
• Christophe Roland, Ph.D, Universite de Sciences et Technologie de Lille, Lille, France
• Ravi Varadhan, Ph.D., Johns Hopkins University, Baltimore, MD